Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Sarah X, Zhang"'
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303010 (2024)
Diabetic Retinopathy (DR) is the leading cause of vision loss in working-age adults. The hallmark features of DR include vascular leakage, capillary loss, retinal ischemia, and aberrant neovascularization. Although the pathophysiology is not fully un
Externí odkaz:
https://doaj.org/article/9e2fdc70366b4bafa4388c0dd2250ae2
Autor:
Treefa Shwani, Charles Zhang, Leah A. Owen, Akbar Shakoor, Albert T. Vitale, John H. Lillvis, Julie L. Barr, Parker Cromwell, Robert Finley, Nadine Husami, Elizabeth Au, Rylee A. Zavala, Elijah C. Graves, Sarah X. Zhang, Michael H. Farkas, David A. Ammar, Karen M. Allison, Amany Tawfik, Richard M. Sherva, Mingyao Li, Dwight Stambolian, Ivana K. Kim, Lindsay A. Farrer, Margaret M. DeAngelis
Publikováno v:
Cells, Vol 12, Iss 23, p 2668 (2023)
Age-related macular degeneration (AMD) is a leading cause of blindness, and elucidating its underlying disease mechanisms is vital to the development of appropriate therapeutics. We identified differentially expressed genes (DEGs) and differentially
Externí odkaz:
https://doaj.org/article/e8beab75624a4f28ace7d19d17448129
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-19 (2022)
Abstract Background The retina, as part of the central nervous system (CNS) with limited capacity for self-reparation and regeneration in mammals, is under cumulative environmental stress due to high-energy demands and rapid protein turnover. These s
Externí odkaz:
https://doaj.org/article/d6289304eeac42d9acb3035f971ba517
Autor:
Aneliya Hanineva, Karen Sophia Park, Joshua J Wang, Margaret M DeAngelis, Michael H Farkas, Sarah X Zhang
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 9, Pp 1875-1880 (2022)
Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the
Externí odkaz:
https://doaj.org/article/53a4fc89cc41460eb5c4c880a76b07ab
Autor:
Todd McLaughlin, Jinli Wang, Liyun Jia, Fuguo Wu, Yaqin Wang, Joshua J. Wang, Xiuqian Mu, Sarah X. Zhang
Publikováno v:
Cells, Vol 12, Iss 12, p 1558 (2023)
p58IPK is a multifaceted endoplasmic reticulum (ER) chaperone and a regulator of eIF2α kinases involved in a wide range of cellular processes including protein synthesis, ER stress response, and macrophage-mediated inflammation. Systemic deletion of
Externí odkaz:
https://doaj.org/article/48ecd1f9bfd44090a3e71d17a4fe9acc
Autor:
Joshua J. Wang, Karen Sophia Park, Narayan Dhimal, Shichen Shen, Xixiang Tang, Jun Qu, Sarah X. Zhang
Publikováno v:
Cells, Vol 11, Iss 18, p 2819 (2022)
The mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) is the physical contact site between the ER and the mitochondria and plays a vital role in the regulation of calcium signaling, bioenergetics, and inflammation. Disturbances in the
Externí odkaz:
https://doaj.org/article/3638b81fd7a742fe9bc7be7add47c229
Autor:
Todd McLaughlin, Marek Falkowski, Jae Whan Park, Stephen Keegan, Michael Elliott, Joshua J. Wang, Sarah X. Zhang
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-15 (2018)
Abstract Background Aging is the strongest risk factor for neurodegenerative diseases and extended age results in neuronal degeneration and functional decline in the visual system. Among many contributing factors to age-related deterioration of neuro
Externí odkaz:
https://doaj.org/article/099ba4e4a8c94980abef9117bcd3036a
Autor:
Jacey Hongjie Ma, Shichen Shen, Joshua J. Wang, Zhanwen He, Amanda Poon, Jun Li, Jun Qu, Sarah X. Zhang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract The mitochondria-associated ER membrane (MAM) plays a critical role in cellular energetics and calcium homeostasis; however, how MAM is affected under diabetic condition remains elusive. This study presented a comprehensive proteome profilin
Externí odkaz:
https://doaj.org/article/ce9c478c4c0b4f5fa2c4d156f1fa001e
Autor:
Benjamin Brenner, Yang Zhang, Junghun Kweon, Raymond Fang, Nader Sheibani, Sarah X. Zhang, Cheng Sun, Hao F. Zhang
The morphology of mitochondria provides insights into their functions. Three-dimensional (3D) single-molecule localization microscopy (SMLM) uniquely enables the analysis of mitochondrial morphological features individually, thanks to its high resolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a30c1e67a42fa0de0e561465476cec15
https://doi.org/10.1101/2023.05.10.540227
https://doi.org/10.1101/2023.05.10.540227
Autor:
Chen Chen, Yimin Zhong, Joshua J. Wang, Qiang Yu, Kendra Plafker, Scott Plafker, Sarah X. Zhang
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Normal function of the retinal pigment epithelium (RPE) is essential for maintaining the structural integrity of retinal photoreceptors and the visual process. Sustained oxidative damage of the RPE due to aging and other risk factors contributes to t
Externí odkaz:
https://doaj.org/article/6055f4dc1b1b4c40bde50df3c2e61723