Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sarah Wazir"'
Autor:
Sven T. Sowa, Albert Galera-Prat, Sarah Wazir, Heli I. Alanen, Mirko M. Maksimainen, Lari Lehtiö
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101147- (2022)
Summary: Here, we describe a protocol to set up a screening assay for ADP-ribosyl binding proteins including proteins that possess O-glycosidase or N-glycosidase activities. The FRET-based assay measures the interaction of any ADP-ribosyl binding pro
Externí odkaz:
https://doaj.org/article/5757d53f46f04a1595194b95e88c4132
Publikováno v:
Acta Crystallogr F Struct Biol Commun
MacroD2 is one of the three human macrodomain proteins characterized by their protein-linked mono-ADP-ribosyl-hydrolyzing activity. MacroD2 is a single-domain protein that contains a deep ADP-ribose-binding groove. In this study, new crystallization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc7aa0b7f881b5ced183e518fff2295
https://doi.org/10.1107/s2053230x20011309
https://doi.org/10.1107/s2053230x20011309
Autor:
Lavinia M. Sherrill, Elva E. Joya, AnnMarie Walker, Anuradha Roy, Yousef M. Alhammad, Moriama Atobatele, Sarah Wazir, George Abbas, Patrick Keane, Junlin Zhuo, Anthony K.L. Leung, David K. Johnson, Lari Lehtiö, Anthony R. Fehr, Dana Ferraris
Publikováno v:
bioRxiv
A series of amino acid based7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to discern the structure activity relationships against the SARS-CoV-2 nsp3 macrodomain (Mac1), an ADP-ribosylhydrolase that is critical for coronavirus replicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5507ce1d04acfe835120941ecad7c2
https://pubmed.ncbi.nlm.nih.gov/35597097
https://pubmed.ncbi.nlm.nih.gov/35597097
Autor:
Anu Roy, Yousef M. Alhammad, Peter McDonald, David K. Johnson, Junlin Zhuo, Sarah Wazir, Dana Ferraris, Lari Lehtiö, Anthony K.L. Leung, Anthony R. Fehr
Publikováno v:
bioRxiv
The emergence of several zoonotic viruses in the last twenty years, especially the pandemic outbreak of SARS-CoV-2, has exposed a dearth of antiviral drug therapies for viruses with pandemic potential. Developing a diverse drug portfolio will be crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cae27af75b2972422623a14f12d7aa
http://urn.fi/urn:nbn:fi-fe2023020225594
http://urn.fi/urn:nbn:fi-fe2023020225594
Autor:
Sari, Mattila, Pirjo, Merilahti, Sarah, Wazir, Tania, Quirin, Mirko M, Maksimainen, Yuezhou, Zhang, Henri, Xhaard, Lari, Lehtiö, Tero, Ahola
Publikováno v:
Antimicrob Agents Chemother
Alphaviruses are positive-strand RNA viruses causing febrile disease. Macrodomain-containing proteins, involved in ADP-ribose-mediated signaling, are encoded by both host cells and several virus groups, including alphaviruses. In this study, compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a957bc5a9bce67c8c11b79036a9608e5
https://pubmed.ncbi.nlm.nih.gov/34606339
https://pubmed.ncbi.nlm.nih.gov/34606339
Autor:
Heli I. Alanen, Sven T. Sowa, Albert Galera-Prat, Sarah Wazir, Lari Lehtiö, Mirko M. Maksimainen
Publikováno v:
Cell Reports Methods
Proteins interacting with ADP-ribosyl groups are often involved in disease-related pathways or viral infections, making them attractive drug targets. We present a robust and accessible assay applicable to both hydrolysing or non-hydrolysing binders o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add08bb2386fad8ba3ab5e28cbc4da4c
https://pubmed.ncbi.nlm.nih.gov/34786571
https://pubmed.ncbi.nlm.nih.gov/34786571
ADP-ribosylation is a post-translational modification involved in the regulation of many vital cellular processes. This posttranslational modification is carried out by ADP-ribosyltransferases converting β-NAD+ into nicotinamide and a protein-linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8366751396fa5ee0eaf62934ee517616
http://urn.fi/urn:nbn:fi-fe2020120899823
http://urn.fi/urn:nbn:fi-fe2020120899823