Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sarah Warda"'
Autor:
Juan Yan, Yuedan Chen, Amish J. Patel, Sarah Warda, Cindy J. Lee, Briana G. Nixon, Elissa W.P. Wong, Miguel A. Miranda-Román, Ning Yang, Yi Wang, Mohini R. Pachai, Jessica Sher, Emily Giff, Fanying Tang, Ekta Khurana, Sam Singer, Yang Liu, Phillip M. Galbo Jr., Jesper L.V. Maag, Richard P. Koche, Deyou Zheng, Cristina R. Antonescu, Liang Deng, Ming O. Li, Yu Chen, Ping Chi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
Immune checkpoint blockade (ICB) has demonstrated clinical success in “inflamed” tumors with substantial T cell infiltrates, but tumors with an immune-desert tumor microenvironment (TME) fail to benefit. The tumor cell–intrinsic molecular mecha
Externí odkaz:
https://doaj.org/article/5f861c04fcd24ec597718aa39450c410
Autor:
Ping Chi, Yu Chen, Deyou Zheng, Cristina R. Antonescu, Jacob L. Glass, Richard P. Koche, Joseph M. Scandura, Sarat Chandarlapaty, Charles M. Rudin, Jonathan A. Fletcher, Michael T. McCabe, Melissa B. Pappalardi, Emily Giff, Juan Yan, Elissa W.P. Wong, Yinuo Meng, Eve Fishinevich, Gabriella Bayshtok, Naitao Wang, Dan Li, Cindy J. Lee, Mohini R. Pachai, Miguel A. Miranda-Román, Rohan Misra, Jesper L.V. Maag, Sarah Warda, Amish J. Patel
Polycomb repressive complex 2 (PRC2) has oncogenic and tumor-suppressive roles in cancer. There is clinical success of targeting this complex in PRC2-dependent cancers, but an unmet therapeutic need exists in PRC2-loss cancer. PRC2-inactivating mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddd2212905d2044de7e4a7a9f01b27a
https://doi.org/10.1158/2159-8290.c.6549502.v1
https://doi.org/10.1158/2159-8290.c.6549502.v1
Autor:
Ping Chi, Yu Chen, Deyou Zheng, Cristina R. Antonescu, Jacob L. Glass, Richard P. Koche, Joseph M. Scandura, Sarat Chandarlapaty, Charles M. Rudin, Jonathan A. Fletcher, Michael T. McCabe, Melissa B. Pappalardi, Emily Giff, Juan Yan, Elissa W.P. Wong, Yinuo Meng, Eve Fishinevich, Gabriella Bayshtok, Naitao Wang, Dan Li, Cindy J. Lee, Mohini R. Pachai, Miguel A. Miranda-Román, Rohan Misra, Jesper L.V. Maag, Sarah Warda, Amish J. Patel
Supplementary Data from PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f847d5ee315f0b1a992e649f77a1c97
https://doi.org/10.1158/2159-8290.22540900.v1
https://doi.org/10.1158/2159-8290.22540900.v1
Autor:
Amish J. Patel, Sarah Warda, Jesper L.V. Maag, Rohan Misra, Miguel A. Miranda-Román, Mohini R. Pachai, Dan Li, Naitao Wang, Cindy J. Lee, Gabriella Bayshtok, Eve Fishinevich, Yinuo Meng, Elissa W.P. Wong, Juan Yan, Emily Giff, Melissa B. Pappalardi, Michael T. McCabe, Jonathan A. Fletcher, Joseph M. Scandura, Richard P. Koche, Jacob L. Glass, Cristina R. Antonescu, Deyou Zheng, Yu Chen, Ping Chi
Polycomb Repressive Complex 2 (PRC2) establishes and maintains di- and tri-methylation at histone 3 at lysine 27 (H3K27me2/3) in the genome and plays oncogenic and tumor suppressor roles in context-dependent cancer pathogenesis. While there is clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec4527e306b11975ed3e56616f8ce10d
https://doi.org/10.1101/2022.05.28.493429
https://doi.org/10.1101/2022.05.28.493429
Autor:
Juan Yan, Yuedan Chen, Amish J. Patel, Sarah Warda, Briana G. Nixon, Elissa W.P. Wong, Miguel A. Miranda-Román, Cindy J. Lee, Ning Yang, Yi Wang, Jessica Sher, Emily Giff, Fanying Tang, Ekta Khurana, Sam Singer, Yang Liu, Phillip M. Galbo, Jesper L. Maag, Richard P. Koche, Deyou Zheng, Liang Deng, Cristina R. Antonescu, Ming Li, Yu Chen, Ping Chi
Immune checkpoint blockade (ICB) has demonstrated clinical success in “inflamed” tumors with significant T-cell infiltrates, but tumors with an immune-desert tumor microenvironment (TME) fail to benefit. The tumor cell-intrinsic molecular mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c3e30d42629a5df69dc99352a3c9ef0
https://doi.org/10.1101/2022.05.27.493507
https://doi.org/10.1101/2022.05.27.493507
Autor:
Ping Chi, Li-Xuan Qin, Bastien Nguyen, Ciara M. Kelly, Sandra P. D'Angelo, Mark A. Dickson, Mrinal M. Gounder, Mary L. Keohan, Sujana Movva, Benjamin A. Nacev, Evan Rosenbaum, Katherine A. Thornton, Aimee M. Crago, Sam Yoon, Gary Ulaner, Randy Yeh, Moriah Martindale, Haley T. Phelan, Matthew D. Biniakewitz, Sarah Warda, Cindy J. Lee, Michael F. Berger, Nikolaus D. Schultz, Samuel Singer, Sinchun Hwang, Yu Chen, Cristina R. Antonescu, William D. Tap
Publikováno v:
J Clin Oncol
PURPOSE Dual targeting of the gastrointestinal stromal tumor (GIST) lineage-specific master regulators, ETV1 and KIT, by MEK and KIT inhibitors were synergistic preclinically and may enhance clinical efficacy. This trial was designed to test the effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f46cf58e6301e04e249601ab5593cad
https://europepmc.org/articles/PMC8937014/
https://europepmc.org/articles/PMC8937014/
Autor:
Amish J. Patel, Sarah Warda, Jesper L.V. Maag, Rohan Misra, Miguel A. Miranda-Román, Mohini R. Pachai, Cindy J. Lee, Dan Li, Naitao Wang, Gabriella Bayshtok, Eve Fishinevich, Yinuo Meng, Elissa W.P. Wong, Juan Yan, Emily Giff, Melissa B. Pappalardi, Michael T. McCabe, Jonathan A. Fletcher, Charles M. Rudin, Sarat Chandarlapaty, Joseph M. Scandura, Richard P. Koche, Jacob L. Glass, Cristina R. Antonescu, Deyou Zheng, Yu Chen, Ping Chi
Publikováno v:
Cancer discovery. 12(9)
Polycomb repressive complex 2 (PRC2) has oncogenic and tumor-suppressive roles in cancer. There is clinical success of targeting this complex in PRC2-dependent cancers, but an unmet therapeutic need exists in PRC2-loss cancer. PRC2-inactivating mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58f48af1634a87c2e9712cc582c46c6
https://pubmed.ncbi.nlm.nih.gov/36052503
https://pubmed.ncbi.nlm.nih.gov/36052503
Autor:
Naitao Wang, Mohini R. Pachai, Dan Li, Cindy Lee, Sarah Warda, Guojia Xie, Cheng Qian, Wai Pung E. Wong, Juan Yan, Wenhuo Hu, Alison Smith, Kai Ge, Sarat Chandarlapaty, Gopakumar V. Iyer, Jonathan E. Rosenberg, David B. Solit, Hikmat A. AI-Ahmadie, Ping Chi, Yu Chen
Publikováno v:
Cancer Research. 82:B003-B003
Urothelial carcinoma (UC) is widely recognized to arise from a “field” of precancerous but histologically normal urothelium (HNU). The molecular mechanism that licenses the “field effect” remains elusive. Recent studies revealed prevalent KMT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39917ec6d2cb308412ed87666c8e16e1
https://doi.org/10.1158/1538-7445.cancepi22-b003
https://doi.org/10.1158/1538-7445.cancepi22-b003
Autor:
Ping Chi, Amish J. Patel, Sarah Warda, Jesper L.V. Maag, Rohan Misra, Miguel A. Miranda-Román, Mohini R. Pachai, Cindy J. Lee, Dan Li, Naitao Wang, Gabriella Bayshtok, Eve Fishinevich, Yinuo Meng, Elissa W.P. Wong, Juan Yan, Emily Giff, Jonathan Fletcher, Joseph M. Scandura, Richard Koche, Jacob L. Glass, Cristina R. Antonescu, Deyou Zheng, Yu Chen
Publikováno v:
Clinical Cancer Research. 28:PR005-PR005
Polycomb Repressive Complex 2 (PRC2) establishes and maintains di- and tri-methylation at histone 3 at lysine 27 (H3K27me2/3) in the genome and plays oncogenic and tumor suppressor roles in context-dependent cancer pathogenesis. While there is clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75155d247d9208275c020796ac62b653
https://doi.org/10.1158/1557-3265.sarcomas22-pr005
https://doi.org/10.1158/1557-3265.sarcomas22-pr005
Autor:
Juan Yan, Yuedan Chen, Amish J. Patel, Sarah Warda, Cindy J. Lee, Briana G. Nixon, Elissa W.P. Wong, Miguel A. Miranda-Román, Ning Yang, Yi Wang, Mohini R. Pachai, Jessica Sher, Emily Giff, Fanying Tang, Ekta Khurana, Sam Singer, Yang Liu, Phillip M. Galbo, Jesper L.V. Maag, Richard P. Koche, Deyou Zheng, Cristina R. Antonescu, Liang Deng, Ming O. Li, Yu Chen, Ping Chi
Publikováno v:
The Journal of clinical investigation. 132(17)
Immune checkpoint blockade (ICB) has demonstrated clinical success in "inflamed" tumors with substantial T cell infiltrates, but tumors with an immune-desert tumor microenvironment (TME) fail to benefit. The tumor cell-intrinsic molecular mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c931fb44c66ea5c53605e85e8a92e709
https://pubmed.ncbi.nlm.nih.gov/35852856
https://pubmed.ncbi.nlm.nih.gov/35852856