Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Sarah W Harcum"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Large-scale manufacturing of induced pluripotent stem cells (iPSCs) is essential for cell therapies and regenerative medicines. Yet, iPSCs form large cell aggregates in suspension bioreactors, resulting in insufficient nutrient supply and ex
Externí odkaz:
https://doaj.org/article/f6b1c6618f664fadbd00c44a8415b29c
Autor:
Dylan G. Chitwood, Qinghua Wang, Stephanie R. Klaubert, Kiana Green, Cathy H. Wu, Sarah W. Harcum, Christopher A. Saski
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Chinese hamster ovary (CHO) cell lines are widely used to manufacture biopharmaceuticals. However, CHO cells are not an optimal expression host due to the intrinsic plasticity of the CHO genome. Genome plasticity can lead to chromosomal rear
Externí odkaz:
https://doaj.org/article/b7bcaffad73e48c990a4f49fc0105040
Machine Learning and Deep Learning Strategies for Chinese Hamster Ovary Cell Bioprocess Optimization
Autor:
Tiffany-Marie D. Baako, Sahil Kaushik Kulkarni, Jerome L. McClendon, Sarah W. Harcum, Jordon Gilmore
Publikováno v:
Fermentation, Vol 10, Iss 5, p 234 (2024)
The use of machine learning and deep learning has become prominent within various fields of bioprocessing for countless modeling and prediction tasks. Previous reviews have emphasized machine learning applications in various fields of bioprocessing,
Externí odkaz:
https://doaj.org/article/b5d6d88d7ae54b779d424b35adaced4b
Autor:
Dylan G. Chitwood, Qinghua Wang, Kathryn Elliott, Aiyana Bullock, Dwon Jordana, Zhigang Li, Cathy Wu, Sarah W. Harcum, Christopher A. Saski
Publikováno v:
BMC Biotechnology, Vol 21, Iss 1, Pp 1-16 (2021)
Abstract Background As bioprocess intensification has increased over the last 30 years, yields from mammalian cell processes have increased from 10’s of milligrams to over 10’s of grams per liter. Most of these gains in productivity can be attrib
Externí odkaz:
https://doaj.org/article/0028912c2305477aa65494d16f1770fc
Autor:
Neelima Dahal, Jeffrey A. Osterberg, Benjamin Braun, Tom P. Caldwell, Ralu Divan, Sarah W. Harcum, Pingshan Wang
Publikováno v:
IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology. 6:566-573
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c662a6b285bd83e352389c15a5b0948
https://doi.org/10.1109/jerm.2022.3201698
https://doi.org/10.1109/jerm.2022.3201698
Publikováno v:
IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology. 6:52-60
Radio frequency (RF) non-thermal (NT) bio-effects have been a subject of debate and attracted significant interests due to potential health risks or beneficial applications. In this work, we report a systematic method for broadband investigation of R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb6f389019c0ba3f7c7feb89474a4ea
https://doi.org/10.1109/jerm.2021.3101408
https://doi.org/10.1109/jerm.2021.3101408
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0213419 (2019)
In cancer tumors, lactate accumulation was initially attributed to high glucose consumption associated with the Warburg Effect. Now it is evident that lactate can also serve as an energy source in cancer cell metabolism. Additionally, lactate has bee
Externí odkaz:
https://doaj.org/article/e33f1578f9b24451ac0954968b659931
Autor:
Lauren T. Cordova, Hussain Dahodwala, Kathryn S. Elliott, Jongyoun Baik, Daniel C. Odenewelder, Douglas Nmagu, Bradley A. Skelton, Lisa Uy, Stephanie R. Klaubert, Benjamin F. Synoground, Dylan G. Chitwood, Venkata Gayatri Dhara, Harnish Mukesh Naik, Caitlin S. Morris, Seongkyu Yoon, Michael Betenbaugh, Jon Coffman, Frank Swartzwelder, Michael P. Gillmeister, Sarah W. Harcum, Kelvin H. Lee
Publikováno v:
Biotechnology and bioengineeringREFERENCES.
Due to the favorable attributes of Chinese hamster ovary (CHO) cells for therapeutic proteins and antibodies biomanufacturing, companies generate proprietary cells with desirable phenotypes. One key attribute is the ability to stably express multi-gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b57544b52ac58fe499c41499dcc9c0
https://pubmed.ncbi.nlm.nih.gov/36411514
https://pubmed.ncbi.nlm.nih.gov/36411514
Autor:
Sarah W. Harcum, Thomas P. Caldwell
Publikováno v:
Fermentation, Vol 6, Iss 1, p 8 (2020)
A major economic obstacle in lignocellulosic ethanol production is the low sugar concentrations in the hydrolysate and subsequent fermentation to economically distillable ethanol concentrations. We have previously demonstrated a two-stage fermentatio
Externí odkaz:
https://doaj.org/article/69678d50b0ff454a8a7e1613ce55dbc2