How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis

Autor: Darrel P Francis, Anthony De Soyza, Clare Coyle, Prapa Kanagaratnam, Michael Brown, James B Galloway, Li Su, Mark Toshner, Nicholas J Matheson, Grant D Stewart, Jane Greenaway, Nick G Cunniffe, Simon J Gunter, Sarah W Burge, Tom Dymond, Hanif Esmail, Jacqui Galloway, Effrossyni Gkrania-Klotsas, George Katritsis, Martin D Knolle, Kelly Leonard, Zoe C McIntyre, Ben Prudon, Tommy Rampling, Mili Estee Torok, Ben Warne, Mark Yates, Sofia Villar

Publikováno v: BMJ Open, Vol 10, Iss 10 (2020)

Objectives To analyse enrolment to interventional trials during the first wave of the COVID-19 pandemic in England and describe the barriers to successful recruitment in the circumstance of a further wave or future pandemics.Design We analysed regist

Externí odkaz: https://doaj.org/article/9aa77797e2424303a05fbcb0e47a38f3

The Yorkshire Kidney Screening Trial (YKST):protocol for a feasibility study of adding non-contrast abdominal CT scanning to screen for kidney cancer and other abdominal pathology within a trial of community-based CT screening for lung cancer

Autor: Juliet A Usher-Smith, Angela Godoy, Sarah W Burge, Simon Burbidge, Jon Cartledge, Philip A J Crosbie, Claire Eckert, Fiona Farquhar, David Hammond, Neil Hancock, Gareth R Iball, Michael Kimuli, Golnessa Masson, Richard D Neal, Suzanne Rogerson, Sabrina H Rossi, Evis Sala, Andrew Smith, Stephen J Sharp, Irene Simmonds, Tom Wallace, Matthew Ward, Matthew E J Callister, Grant D Stewart

Publikováno v: Usher-Smith, J A, Godoy, A, Burge, S W, Burbidge, S, Cartledge, J, Crosbie, P A J, Eckert, C, Farquhar, F, Hammond, D, Hancock, N, Iball, G R, Kimuli, M, Masson, G, Neal, R D, Rogerson, S, Rossi, S H, Sala, E, Smith, A, Sharp, S J, Simmonds, I, Wallace, T, Ward, M, Callister, M E J & Stewart, G D 2022, ' The Yorkshire Kidney Screening Trial (YKST) : protocol for a feasibility study of adding non-contrast abdominal CT scanning to screen for kidney cancer and other abdominal pathology within a trial of community-based CT screening for lung cancer ', BMJ Open, vol. 12, no. 9, e063018 . https://doi.org/10.1136/bmjopen-2022-063018

Peer reviewed: True
Acknowledgements: The authors thank the patient and public representations who have contributed to this study, Phil Alsop and Philip Dondi. They also thank the YLST study team and members of the YKST IDMC (Paul Nathan (Chair)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3200d75677a712027c51b8734e09cdf
https://research.manchester.ac.uk/en/publications/a2ae91ab-f98c-4537-aeb4-62de584e61b3

A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells

Autor: Laura Woods, Claire E. Senner, Hanneke Okkenhaug, Vicente Perez-Garcia, Stephanie Chrysanthou, Myriam Hemberger, Sarah W. Burge, Elena Fineberg

Publikováno v: Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 4, Pp 1355-1368 (2018)

Summary The ten-eleven translocation (TET) proteins are well known for their role in maintaining naive pluripotency of embryonic stem cells. Here, we demonstrate that, jointly, TET1 and TET2 also safeguard the self-renewal potential of trophoblast st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8362dac6e1ca6da1870b278f810c7a34
http://europepmc.org/articles/PMC5998911

RNAcentral: an international database of ncRNA sequences

Autor: Robert D. Finn, Nam-Hai Chua, Paul J. Kersey, Runsheng Chen, Mathew W. Wright, Weimin Zhu, Geir Skogerbø, Kim D. Pruitt, Robin R. Gutell, Benli Chai, Simon Kay, Alex Bateman, J. Michael Cherry, His Yuan Huang, Artemis G. Hatzigeorgiou, Patricia P. Chan, Eugene Kulesha, Kelly P. Williams, Elspeth A. Bruford, Anton I. Petrov, Sam Griffiths-Jones, Jacek Wower, Michael B. Clark, Janusz M. Bujnicki, Xiu Cheng Quek, Yi Zhao, Hsien Da Huang, Christian W Zwieb, Marcel E. Dinger, Sarah W. Burge, Huan Wang, Richard Gibson, Todd M. Lowe, Guy Cochrane, Jun Liu, James R. Cole, Dan Staines, Corey M. Hudson, Jennifer Harrow

Publikováno v: Nucleic Acids Research
Griffiths-Jones, S 2014, ' RNAcentral: an international database of ncRNA sequences. ', Nucleic acids research . https://doi.org/10.1093/nar/gku991

The field of non-coding RNA biology has been hampered by the lack of availability of a comprehensive, up-to-date collection of accessioned RNA sequences. Here we present the first release of RNAcentral, a database that collates and integrates informa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a383da0f6af748e5f3b3b0845212eec
https://doi.org/10.1093/nar/gku991

Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks

Autor: Brian J. Cox, David Oxley, Sarah W. Burge, Arnold R. Sienerth, Paulina A. Latos, Myriam Hemberger, Alexander Murray, Claire E. Senner, Masanaga Muto, Masahito Ikawa

Publikováno v: Genesdevelopment. 29(23)

Latos, P. A., Sienerth, A. R., Murray, A., Senner, C. E., Muto, M., Ikawa, M., . . . Hemberger, M. (2015). Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry sensitive shifts i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46289dac88a124f633271ac70b4ea0af
https://pubmed.ncbi.nlm.nih.gov/26584622