Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sarah Vascellari"'
Autor:
Sarah Vascellari, Christina D Orrù, Bradley R Groveman, Sabiha Parveen, Giuseppe Fenu, Giada Pisano, Giuseppe Piga, Giulia Serra, Valentina Oppo, Daniela Murgia, Andrea Perra, Fabrizio Angius, Andrew G Hughson, Cathryn L Haigh, Aldo Manzin, Giovanni Cossu, Byron Caughey
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011456 (2023)
Abnormal deposition of α-synuclein is a key feature and biomarker of Parkinson's disease. α-Synuclein aggregates can propagate themselves by a prion-like seeding-based mechanism within and between tissues and are hypothesized to move between the in
Externí odkaz:
https://doaj.org/article/f1359ada37b94233a8723855297fbd28
Autor:
Silvia Puxeddu, Alessandra Scano, Mariano Andrea Scorciapino, Ilenia Delogu, Sarah Vascellari, Guido Ennas, Aldo Manzin, Fabrizio Angius
Publikováno v:
Molecules, Vol 29, Iss 3, p 679 (2024)
Drug resistance represents one of the great plagues of our time worldwide. This largely limits the treatment of common infections and requires the development of new antibiotics or other alternative approaches. Noteworthy, the indiscriminate use of a
Externí odkaz:
https://doaj.org/article/ad07198082a2441099be45c58c53e542
Autor:
Vanessa Palmas, Silvia Pisanu, Veronica Madau, Emanuela Casula, Andrea Deledda, Roberto Cusano, Paolo Uva, Sarah Vascellari, Andrea Loviselli, Aldo Manzin, Fernanda Velluzzi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract In the present study, we characterized the distinctive signatures of the gut microbiota (GM) from overweight/obese patients (OB), and normal-weight controls (NW), both of Sardinian origin. Fecal bacterial composition of 46 OB patients (BMI =
Externí odkaz:
https://doaj.org/article/11438df90bd04dbc9713709fbb71bc0a
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Prion diseases, synucleinopathies and tauopathies are neurodegenerative disorders characterized by deposition of abnormal protein aggregates in brain and other tissues. These aggregates consist of misfolded forms of prion, α-synuclein (αSyn), or ta
Externí odkaz:
https://doaj.org/article/5df5f6ef9a154dabb2b6c3d09bddb2ed
Autor:
Sarah Vascellari, Vanessa Palmas, Marta Melis, Silvia Pisanu, Roberto Cusano, Paolo Uva, Daniela Perra, Veronica Madau, Marianna Sarchioto, Valentina Oppo, Nicola Simola, Micaela Morelli, Maria Laura Santoru, Luigi Atzori, Maurizio Melis, Giovanni Cossu, Aldo Manzin
Publikováno v:
mSystems, Vol 5, Iss 5 (2020)
ABSTRACT Parkinson’s disease is a neurodegenerative disorder characterized by the accumulation of intracellular aggregates of misfolded alpha-synuclein along the cerebral axis. Several studies report the association between intestinal dysbiosis and
Externí odkaz:
https://doaj.org/article/809869bcae4e4aafac202dd23e421b0b
Autor:
Sarah Vascellari, Marta Melis, Vanessa Palmas, Silvia Pisanu, Alessandra Serra, Daniela Perra, Maria Laura Santoru, Valentina Oppo, Roberto Cusano, Paolo Uva, Luigi Atzori, Micaela Morelli, Giovanni Cossu, Aldo Manzin
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 144 (2021)
Parkinson’s disease (PD) is a clinically heterogenic disorder characterized by distinct clinical entities. Most studies on motor deficits dichotomize PD into tremor dominant (TD) or non-tremor dominant (non-TD) with akinetic-rigid features (AR). Di
Externí odkaz:
https://doaj.org/article/27c8cac0297b445989eb71c5ebf088cc
Autor:
Sarah Vascellari, Christina D Orrù, Andrew G Hughson, Declan King, Rona Barron, Jason M Wilham, Gerald S Baron, Brent Race, Alessandra Pani, Byron Caughey
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48969 (2012)
Different transmissible spongiform encephalopathy (TSE)-associated forms of prion protein (e.g. PrP(Sc)) can vary markedly in ultrastructure and biochemical characteristics, but each is propagated in the host. PrP(Sc) propagation involves conversion
Externí odkaz:
https://doaj.org/article/3f2b49e1133f4cd58ac570744e3a08ee
Autor:
Paolo Uva, Veronica Madau, Fernanda Velluzzi, Andrea Loviselli, Roberto Cusano, Emanuela Casula, Andrea Deledda, Vanessa Palmas, Sarah Vascellari, Silvia Pisanu, Aldo Manzin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
In the present study, we characterized the distinctive signatures of the gut microbiota (GM) from overweight/obese patients (OB), and normal-weight controls (NW), both of Sardinian origin. Fecal bacterial composition of 46 OB patients (BMI = 36.6 ±
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f55c19065435c0fb61f188577e4fc07
https://doaj.org/article/11438df90bd04dbc9713709fbb71bc0a
https://doaj.org/article/11438df90bd04dbc9713709fbb71bc0a
Autor:
Vanessa Palmas, Valentina Oppo, Giovanni Cossu, Daniela Perra, Sarah Vascellari, Roberto Cusano, Michele Fiorini, Melania Melis, Marta Melis, Aldo Manzin, Micaela Morelli, Iole Tomassini Barbarossa, Alessandra Serra
Publikováno v:
International Journal of Biological Macromolecules. 165:665-674
The non-tasting form of the bitter taste receptor, TAS2R38, has been shown as a genetic risk factor associated with the development of Parkinson's disease (PD). Specific taste receptors that are expressed in the lower gastrointestinal tract may respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a87b5689bedb2adf4fa29e09383256e
https://doi.org/10.1016/j.ijbiomac.2020.09.056
https://doi.org/10.1016/j.ijbiomac.2020.09.056
Autor:
Anna Ladogana, Sandro Orru, Marta Melis, Sarah Vascellari, Giovanni Defazio, Giovanni Cossu, Piero Parchi, Anna Poleggi, Gianluca Floris, Andrea Molari, Luisa Balestrino, Maurizio Melis
Publikováno v:
neurogenetics. 21:251-257
In genetic prion diseases (gPrD), five genetic variants (E200K, V210I, V180I, P102L, and D178N) are responsible for about 85% of cases. The R208H is one of the several additional rare mutations and to date, only 16 cases carrying this mutation have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a10a5a94bb8f42f07682a7cf3ce868
https://doi.org/10.1007/s10048-020-00618-1
https://doi.org/10.1007/s10048-020-00618-1