Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sarah Vascellari"'
Autor:
Sarah Vascellari, Christina D Orrù, Bradley R Groveman, Sabiha Parveen, Giuseppe Fenu, Giada Pisano, Giuseppe Piga, Giulia Serra, Valentina Oppo, Daniela Murgia, Andrea Perra, Fabrizio Angius, Andrew G Hughson, Cathryn L Haigh, Aldo Manzin, Giovanni Cossu, Byron Caughey
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011456 (2023)
Abnormal deposition of α-synuclein is a key feature and biomarker of Parkinson's disease. α-Synuclein aggregates can propagate themselves by a prion-like seeding-based mechanism within and between tissues and are hypothesized to move between the in
Externí odkaz:
https://doaj.org/article/f1359ada37b94233a8723855297fbd28
Autor:
Silvia Puxeddu, Alessandra Scano, Mariano Andrea Scorciapino, Ilenia Delogu, Sarah Vascellari, Guido Ennas, Aldo Manzin, Fabrizio Angius
Publikováno v:
Molecules, Vol 29, Iss 3, p 679 (2024)
Drug resistance represents one of the great plagues of our time worldwide. This largely limits the treatment of common infections and requires the development of new antibiotics or other alternative approaches. Noteworthy, the indiscriminate use of a
Externí odkaz:
https://doaj.org/article/ad07198082a2441099be45c58c53e542
Autor:
Vanessa Palmas, Silvia Pisanu, Veronica Madau, Emanuela Casula, Andrea Deledda, Roberto Cusano, Paolo Uva, Sarah Vascellari, Andrea Loviselli, Aldo Manzin, Fernanda Velluzzi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract In the present study, we characterized the distinctive signatures of the gut microbiota (GM) from overweight/obese patients (OB), and normal-weight controls (NW), both of Sardinian origin. Fecal bacterial composition of 46 OB patients (BMI =
Externí odkaz:
https://doaj.org/article/11438df90bd04dbc9713709fbb71bc0a
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Prion diseases, synucleinopathies and tauopathies are neurodegenerative disorders characterized by deposition of abnormal protein aggregates in brain and other tissues. These aggregates consist of misfolded forms of prion, α-synuclein (αSyn), or ta
Externí odkaz:
https://doaj.org/article/5df5f6ef9a154dabb2b6c3d09bddb2ed
Autor:
Sarah Vascellari, Vanessa Palmas, Marta Melis, Silvia Pisanu, Roberto Cusano, Paolo Uva, Daniela Perra, Veronica Madau, Marianna Sarchioto, Valentina Oppo, Nicola Simola, Micaela Morelli, Maria Laura Santoru, Luigi Atzori, Maurizio Melis, Giovanni Cossu, Aldo Manzin
Publikováno v:
mSystems, Vol 5, Iss 5 (2020)
ABSTRACT Parkinson’s disease is a neurodegenerative disorder characterized by the accumulation of intracellular aggregates of misfolded alpha-synuclein along the cerebral axis. Several studies report the association between intestinal dysbiosis and
Externí odkaz:
https://doaj.org/article/809869bcae4e4aafac202dd23e421b0b
Autor:
Sarah Vascellari, Aldo Manzin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8022 (2021)
The principal pathogenic event in Parkinson’s disease is characterized by the conformational change of α-synuclein, which form pathological aggregates of misfolded proteins, and then accumulate in intraneuronal inclusions causing dopaminergic neur
Externí odkaz:
https://doaj.org/article/c4922230b5f244d5a4357d35a986a29b
Autor:
Sarah Vascellari, Marta Melis, Vanessa Palmas, Silvia Pisanu, Alessandra Serra, Daniela Perra, Maria Laura Santoru, Valentina Oppo, Roberto Cusano, Paolo Uva, Luigi Atzori, Micaela Morelli, Giovanni Cossu, Aldo Manzin
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 144 (2021)
Parkinson’s disease (PD) is a clinically heterogenic disorder characterized by distinct clinical entities. Most studies on motor deficits dichotomize PD into tremor dominant (TD) or non-tremor dominant (non-TD) with akinetic-rigid features (AR). Di
Externí odkaz:
https://doaj.org/article/27c8cac0297b445989eb71c5ebf088cc
Autor:
Silvia Pisanu, Vanessa Palmas, Veronica Madau, Emanuela Casula, Andrea Deledda, Roberto Cusano, Paolo Uva, Sarah Vascellari, Francesco Boi, Andrea Loviselli, Aldo Manzin, Fernanda Velluzzi
Publikováno v:
Nutrients, Vol 12, Iss 9, p 2707 (2020)
Although it is known that the gut microbiota (GM) can be modulated by diet, the efficacy of specific dietary interventions in determining its composition and diversity in obese patients remains to be ascertained. The present work aims to evaluate the
Externí odkaz:
https://doaj.org/article/4a91d0a7b04b4d49939141bf3d697625
Autor:
Michele Fiorini, Giorgia Iselle, Daniela Perra, Matilde Bongianni, Stefano Capaldi, Luca Sacchetto, Sergio Ferrari, Aldo Mombello, Sarah Vascellari, Silvia Testi, Salvatore Monaco, Gianluigi Zanusso
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 880 (2020)
The early and accurate in vivo diagnosis of sporadic Creutzfeldt−Jakob disease (sCJD) is essential in order to differentiate CJD from treatable rapidly progressive dementias. Diagnostic investigations supportive of clinical CJD diagnosis include ma
Externí odkaz:
https://doaj.org/article/01239bb1279a427a988ae1e60d3cdce7
Autor:
Sarah Vascellari, Christina D Orrù, Andrew G Hughson, Declan King, Rona Barron, Jason M Wilham, Gerald S Baron, Brent Race, Alessandra Pani, Byron Caughey
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48969 (2012)
Different transmissible spongiform encephalopathy (TSE)-associated forms of prion protein (e.g. PrP(Sc)) can vary markedly in ultrastructure and biochemical characteristics, but each is propagated in the host. PrP(Sc) propagation involves conversion
Externí odkaz:
https://doaj.org/article/3f2b49e1133f4cd58ac570744e3a08ee