Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sarah Van Tol"'
Autor:
Julia R. Port, Jade C. Riopelle, Sarah van Tol, Arthur Wickenhagen, Eric Bohrnsen, Daniel E. Sturdevant, Rebecca Rosenke, Jamie Lovaglio, Justin Lack, Sarah L. Anzick, Kathleen Cordova, Kwe Claude Yinda, Patrick W. Hanley, Tony Schountz, Lon V. Kendall, Carl I. Shaia, Greg Saturday, Craig Martens, Benjamin Schwarz, Vincent J. Munster
Publikováno v:
npj Viruses, Vol 2, Iss 1, Pp 1-15 (2024)
Abstract The ancestral sarbecovirus giving rise to SARS-CoV-2 is posited to have originated in bats. While SARS-CoV-2 causes asymptomatic to severe respiratory disease in humans, little is known about the biology, virus tropism, and immunity of SARS-
Externí odkaz:
https://doaj.org/article/04082be39d684a2987f4130c09c16462
Autor:
Carlos A Rodríguez-Salazar, Sarah van Tol, Olivier Mailhot, Maria Gonzalez-Orozco, Gabriel T Galdino, Abbey N Warren, Natalia Teruel, Padmanava Behera, Kazi Sabrina Afreen, Lihong Zhang, Terry L Juelich, Jennifer K Smith, María Inés Zylber, Alexander N Freiberg, Rafael J Najmanovich, Maria I Giraldo, Ricardo Rajsbaum
Publikováno v:
PLoS Biology, Vol 22, Iss 2, p e3002544 (2024)
Ebolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase complex, which includes the cofactor and Interferon antagonist VP35. We p
Externí odkaz:
https://doaj.org/article/99a4e0e8910746299e1402b8c51819c3
Publikováno v:
Viruses, Vol 15, Iss 11, p 2147 (2023)
Nipah virus (NiV; genus: Henipavirus; family: Paramyxoviridae) naturally infects Old World fruit bats (family Pteropodidae) without causing overt disease. Conversely, NiV infection in humans and other mammals can be lethal. Comparing bat antiviral re
Externí odkaz:
https://doaj.org/article/af6e44ad4fe941bcb71b15c8c885f3fd
Autor:
Mehdi Moustaqil, Emma Ollivier, Hsin-Ping Chiu, Sarah Van Tol, Paulina Rudolffi-Soto, Christian Stevens, Akshay Bhumkar, Dominic J. B. Hunter, Alexander N. Freiberg, David Jacques, Benhur Lee, Emma Sierecki, Yann Gambin
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 178-195 (2021)
The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication. Here, we discovered new functions of the NSP3 and NSP5 proteases of SA
Externí odkaz:
https://doaj.org/article/abb04dd2b53e469d9a1bf3b2624c8bc7
Autor:
Sarah van Tol, Birte Kalveram, Philipp A Ilinykh, Adam Ronk, Kai Huang, Leopoldo Aguilera-Aguirre, Preeti Bharaj, Adam Hage, Colm Atkins, Maria I Giraldo, Maki Wakamiya, Maria Gonzalez-Orozco, Abbey N Warren, Alexander Bukreyev, Alexander N Freiberg, Ricardo Rajsbaum
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010532 (2022)
Ebola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging, viral polymerase function, and host immune antagonism. The mechanisms regulating VP35's engagement in different functions are not well-understood. We previously s
Externí odkaz:
https://doaj.org/article/7f5b774b9b474e8c892f3effa42555aa
Autor:
Adam Hage, Preeti Bharaj, Sarah van Tol, Maria I. Giraldo, Maria Gonzalez-Orozco, Karl M. Valerdi, Abbey N. Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G. Widen, Hong M. Moulton, Benhur Lee, Jeffrey R. Johnson, Nevan J. Krogan, Adolfo García-Sastre, Pei-Yong Shi, Alexander N. Freiberg, Ricardo Rajsbaum
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110434- (2022)
Summary: Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses. However, few unanchored poly-Ub interactors are known. To identify fact
Externí odkaz:
https://doaj.org/article/1021a0c2a2e14ca9810fefd46e1864bc
Publikováno v:
Parasites & Vectors, Vol 11, Iss 1, Pp 1-15 (2018)
Abstract Background Vector control is critical in reducing the disease burden caused by mosquitoes, and insecticides are an effective tool to control vector populations. Resistance to common insecticides is now widespread, and novel classes of insect
Externí odkaz:
https://doaj.org/article/6581af8a293b4ea897ef1e2f8b5dd000
Publikováno v:
Viruses, Vol 13, Iss 3, p 369 (2021)
Ubiquitination of proteins is a post-translational modification process with many different cellular functions, including protein stability, immune signaling, antiviral functions and virus replication. While ubiquitination of viral proteins can be us
Externí odkaz:
https://doaj.org/article/57e76e43589649a7b54df8425ddb9059
Publikováno v:
Vaccines, Vol 5, Iss 3, p 23 (2017)
The innate antiviral response is integral in protecting the host against virus infection. Many proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin-activating (E1), -conjugating (E2), and -ligating (E3) enzymes work t
Externí odkaz:
https://doaj.org/article/e745f8d1241040218ef9c70c44bd55dc
Publikováno v:
Cell chemical biology. 29(7)
Developing broad-spectrum, host-directed antiviral therapeutics can be adapted to combat emerging viruses. In this issue of Cell Chemical Biology, Maarifi and colleagues implement a Nano luciferase reporter-based protein complementation assay to scre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aae048f8bc03f532b308aae89d04299
https://pubmed.ncbi.nlm.nih.gov/35728599
https://pubmed.ncbi.nlm.nih.gov/35728599