Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Sarah V Harding"'
Autor:
Samuel Kraus, Megan L Fletcher, Urszula Łapińska, Krina Chawla, Evan Baker, Erin L Attrill, Paul O'Neill, Audrey Farbos, Aaron Jeffries, Edouard E Galyov, Sunee Korbsrisate, Kay B Barnes, Sarah V Harding, Krasimira Tsaneva-Atanasova, Mark A T Blaskovich, Stefano Pagliara
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012361 (2024)
The interactions between a virus and its host vary in space and time and are affected by the presence of molecules that alter the physiology of either the host or the virus. Determining the molecular mechanisms at the basis of these interactions is p
Externí odkaz:
https://doaj.org/article/b6c3583e1ed849f4a0d265bd93bc466b
Autor:
Erin L Attrill, Rory Claydon, Urszula Łapińska, Mario Recker, Sean Meaden, Aidan T Brown, Edze R Westra, Sarah V Harding, Stefano Pagliara
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001406 (2021)
Bacteriophages represent an avenue to overcome the current antibiotic resistance crisis, but evolution of genetic resistance to phages remains a concern. In vitro, bacteria evolve genetic resistance, preventing phage adsorption or degrading phage DNA
Externí odkaz:
https://doaj.org/article/a10eff5e12c94ff8a153cfc15a290d0a
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248119 (2021)
Burkholderia pseudomallei is a soil-dwelling organism present throughout the tropics. It is the causative agent of melioidosis, a disease that is believed to kill 89,000 people per year. It is naturally resistant to many antibiotics, requiring at lea
Externí odkaz:
https://doaj.org/article/87a2488d0a28420ab16d82683c70d795
Autor:
Kay B. Barnes, Mark I. Richards, Gary Burgess, Stuart J. Armstrong, Christine Bentley, Thomas C. Maishman, Thomas R. Laws, Michelle Nelson, Sarah V. Harding
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The efficacy of finafloxacin as a component of a layered defense treatment regimen was determined in vitro and in vivo against an infection with Burkholderia pseudomallei. Doxycycline was down-selected from a panel of antibiotics evaluated in vitro a
Externí odkaz:
https://doaj.org/article/e6706cff0d9d4c09827642bcea38ae7d
Autor:
Adam Pattinson, Sandeep Bahia, Gwénaëlle Le Gall, Christopher J. Morris, Sarah V. Harding, Michael McArthur
Publikováno v:
Frontiers in Microbiology. 13
Burkholderia pseudomallei is the causative agent of the tropical disease, melioidosis. It is intrinsically resistant to many antimicrobials and treatment requires an onerous regimen of intravenous and orally administered drugs. Relapse of disease and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41f82b39d19f1291a403ee7308829551
https://doi.org/10.3389/fmicb.2022.1092230
https://doi.org/10.3389/fmicb.2022.1092230
Autor:
Kay B, Barnes, Marc, Bayliss, Carwyn, Davies, Mark I, Richards, Thomas R, Laws, Andreas, Vente, Sarah V, Harding
Publikováno v:
Frontiers in Microbiology. 13
Burkholderia mallei, the causative agent of glanders, is principally a disease of equines, although it can also infect humans and is categorized by the U.S. Centers for Disease Control and Prevention as a category B biological agent. Human cases of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd98ffc687a4a4ff1686a6ddbb64065
https://doi.org/10.3389/fmicb.2022.1057202
https://doi.org/10.3389/fmicb.2022.1057202
Autor:
Thomas R. Laws, Kay B. Barnes, Dominic C. Jenner, Alejandro Núñez, Mark I. Richards, Joanne E. Thwaite, Andreas Vente, David Rushton, Michelle Nelson, Sarah V. Harding
Publikováno v:
Antibiotics; Volume 11; Issue 10; Pages: 1442
Burkholderia pseudomallei is the causative agent of melioidosis, a multifaceted disease. A proportion of the mortality and morbidity reported as a result of infection with this organism may be due to the premature cessation of antibiotic therapy typi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96edff30b20bfb234f80b88da143bb3
Autor:
Michelle Nelson, Kay B. Barnes, Carwyn H. Davies, Christopher K. Cote, J. Matthew Meinig, Sergei S. Biryukov, David N. Dyer, Ondraya Frick, Henry Heine, Denise A. Pfefferle, Amanda Horstman-Smith, Julie Barbaras, Sarah V. Harding
Publikováno v:
Antibiotics. 12:506
Burkholderia pseudomallei, the causative agent of the disease melioidosis, has been isolated from the environment in 45 countries. The treatment of melioidosis is complex, requiring lengthy antibiotic regimens, which can result in the relapse of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::796a50704b38f610544bd12d111e6af6
https://doi.org/10.3390/antibiotics12030506
https://doi.org/10.3390/antibiotics12030506
Autor:
Joss M. Auty, Christopher H. Jenkins, Jennifer Hincks, Anna A. Straatman-Iwanowska, Natalie Allcock, Obolbek Turapov, Edouard E. Galyov, Sarah V. Harding, Galina V. Mukamolova
Publikováno v:
Microbiology Spectrum
Bacteria have developed unique mechanisms to adapt to environmental stresses and challenges of the immune system. Here, we report that Burkholderia pseudomallei, the causative agent of melioidosis, and its laboratory surrogate, Burkholderia thailande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b996c00048943d65bb921c6f68cc7f0
https://doi.org/10.1128/spectrum.02110-21
https://doi.org/10.1128/spectrum.02110-21
Disulfiram, an alcohol dependence therapy, can inhibit the in vitro growth of Francisella tularensis
Autor:
Helen S. Atkins, Helen C. Flick-Smith, José B. Pereira-Leal, Richard Hampson, Kay B. Barnes, Jaroslaw Surkont, Karleigh A. Hamblin, Sarah V. Harding
Publikováno v:
International Journal of Antimicrobial Agents. 54:85-88
Disulfiram (DSF) can help treat alcohol dependency by inhibiting aldehyde dehydrogenase (ALDH). Genomic analysis revealed that Francisella tularensis, the causative agent of tularemia, has lost all but one ALDH-like domain and that this domain retain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d697af8b1515e3a56917462ddcb61748
https://doi.org/10.1016/j.ijantimicag.2019.04.002
https://doi.org/10.1016/j.ijantimicag.2019.04.002