CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease

Autor: Nora Bengoa-Vergniory, Emilie Faggiani, Paula Ramos-Gonzalez, Ecem Kirkiz, Natalie Connor-Robson, Liam V. Brown, Ibrar Siddique, Zizheng Li, Siv Vingill, Milena Cioroch, Fabio Cavaliere, Sarah Threlfell, Bradley Roberts, Thomas Schrader, Frank-Gerrit Klärner, Stephanie Cragg, Benjamin Dehay, Gal Bitan, Carlos Matute, Erwan Bezard, Richard Wade-Martins

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

CLR01 is a molecular tweezer that inhibits protein aggregation. Here the authors show that CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and in mouse models showing potential as a disease-modifying therapy for Parkinson’

Externí odkaz: https://doaj.org/article/dbb405cbb99f4bdb826102e5b534b7da

Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter

Autor: Mark D. Condon, Nicola J. Platt, Yan-Feng Zhang, Bradley M. Roberts, Michael A. Clements, Stefania Vietti-Michelina, Min-Yee Tseu, Katherine R. Brimblecombe, Sarah Threlfell, Edward O. Mann, Stephanie J. Cragg

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Dopamine release in the striatum has important roles in action selection and in disorders such as Parkinson’s disease. The authors here show that short-term plasticity of dopamine release is strongly determined by axonal activation and dopamine tra

Externí odkaz: https://doaj.org/article/b1b396a19d0e49f0914ab423562f96e0

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior

Autor: Benjamin H.M. Hunn, Siv Vingill, Sarah Threlfell, Javier Alegre-Abarrategui, Morgane Magdelyns, Thierry Deltheil, Nora Bengoa-Vergniory, Peter L. Oliver, Milena Cioroch, Natalie M. Doig, David M. Bannerman, Stephanie J. Cragg, Richard Wade-Martins

Publikováno v: Cell Reports, Vol 29, Iss 4, Pp 920-931.e7 (2019)

Summary: Parkinson’s disease (PD) is characterized by the death of dopamine neurons in the substantia nigra pars compacta (SNc) and accumulation of α-synuclein. Impaired autophagy has been implicated and activation of autophagy proposed as a treat

Externí odkaz: https://doaj.org/article/173e703e2233467d9c3680e7a98ca772

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

Autor: Natalie M. Doig, Peter J. Magill, Lisa Conyers, Alexander H.C.W. Agopyan-Miu, Polina Kosillo, Kamran M. Ahmed, Sarah Threlfell, Corinna D. Wong, Helen S. Bateup

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature Communications
Nature Communications, vol 10, iss 1
Nature communications, vol 10, iss 1

Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in TSC1 or TSC2, which encode proteins that negatively regulate mTOR complex 1 (mTORC1). TSC is associated with significant cognitive, psychiatric, and behavioral p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6027e08ce96274727f5f5d61d944e9e
https://doaj.org/article/8f206497b65e4d93a92d89d476e37c28

Astrocytic striatal GABA transporter activity governs dopamine release and shows maladaptive downregulation in early parkinsonism

Autor: Peter J. Magill, Natalie M. Doig, Katherine R. Brimblecombe, N Pasternack, Stephanie J. Cragg, Natalie Connor-Robson, Sarah Threlfell, Emanuel F. Lopes, Bradley M. Roberts, Ruth E. Siddorn, Nora Bengoa-Vergniory, Richard Wade-Martins

SummaryStriatal dopamine (DA) is critical for action and learning. Recent data show DA release is under tonic inhibition by striatal GABA. Ambient striatal GABA tone on striatal projection neurons can be governed by plasma membrane GABA uptake transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cd83168f6e587ae343f2e2a6a86f74