Activated Protein C: A Promising Drug with Multiple Effects?

Autor: Henri M. H. Spronk, Sarah T.B.G. Loubele, H. ten Cate

Publikováno v: Mini-Reviews in Medicinal Chemistry. 9:620-626

The anti-coagulant activated protein C (APC) can exert direct effects on cells, including cytoprotective functions involving apoptosis and inflammation mechanisms. These cytoprotective properties of APC require the presence of protease-activated rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c70f056dd0407e301721d55634617d3
https://doi.org/10.2174/138955709788167547

The anti-coagulants ASIS or APC do not protect against renal ischemia/ reperfusion injury

Autor: Henri M. H. Spronk, Carine J. Peutz-Kootstra, Arnold Spek, Wim A. Buurman, Peter Leenders, Hugo ten Cate, Sarah T.B.G. Loubele, Robert A. Matthijsen

Publikováno v: ScienceOpen Research (2014)

Renal ischemia/reperfusion (I/R) injury is the main cause of acute renal failure. The severity of injury is determined by endothelial damage as well as inflammatory and apoptotic processes. The anti-coagulants active site inhibited factor VIIa (ASIS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac2a9b0c4536b1ce8940a728cf73dd3
https://www.scienceopen.com/document?vid=34421699-3b09-497d-bf20-61b35dfb919f

Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner

Autor: Tilman M. Hackeng, Karly Hamulyák, Sylvia Heeneman, Henri M. H. Spronk, Sarah T.B.G. Loubele, Peter Leenders, Joanne van Ryn, Hartmut Weiler, Hugo ten Cate, Julian I. Borissoff, Rene van Oerle, Oliver Soehnlein, Charles T. Esmon, Erik A.L. Biessen, Jeroen J. T. Otten, Jay L. Degen, Mat J.A.P. Daemen

Publikováno v: PLOS ONE 8(2), e55784 (2013). doi:10.1371/journal.pone.0055784
PLoS ONE, Vol 8, Iss 2, p e55784 (2013)
PLOS ONE, 8(2):e55784. Public Library of Science
PLoS ONE
PLoS ONE, 8(2). Public Library of Science

BACKGROUND: Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects of coagulation proteases. Published experimental studies have yielded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2311bb3d32523f0cf6f56b906a29a5

Activated Protein C Protects Against Myocardial Ischemia/Reperfusion Injury via Inhibition of Apoptosis and Inflammation

Autor: Sarah T.B.G. Loubele, Henri M. H. Spronk, Karly Hamulyák, Rene van Oerle, Gary L. Ferrell, C. Arnold Spek, Charles T. Esmon, Hella L. Aberson, Peter Leenders, Hugo ten Cate

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 29(7), 1087-U159. Lippincott Williams and Wilkins

Objective—In spite of major advances in reperfusion therapy for patients presenting with acute coronary syndrome, long-term morbidity is still substantial. A limitation of initial treatment of myocardial ischemia is the lack of prevention of ischem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b79f72106a00daf74b8041eb56e4d27
https://pure.amc.nl/en/publications/activated-protein-c-protects-against-myocardial-ischemiareperfusion-injury-via-inhibition-of-apoptosis-and-inflammation(dea2ad3d-03e9-45af-8d6c-b86b377db3aa).html

Monitoring Recombinant FVIIa in Hemophilic and Normal Plasma Using a Thrombin Generation Assay

Autor: Sarah T.B.G. Loubele, Rene van Oerle, Hugo ten Cate, Peter L.A. Giesen, Henri M. H. Spronk

Publikováno v: Blood. 118:1207-1207

Abstract 1207 Background: Although the recombinant factor VIIa (rFVIIa) has been registered for use in hemophilia patients with inhibitors, there is still no method to monitor the effects of rFVIIa in restoring the coagulation balance in plasma. Henc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::790628100a409414eb78ebb6e8a12bdf
https://doi.org/10.1182/blood.v118.21.1207.1207