Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sarah Svirsky"'
Autor:
Katherine M. Fronczak, Andrea Roberts, Sarah Svirsky, Madison Parry, Erik Holets, Jeremy Henchir, C. Edward Dixon, Shaun W. Carlson
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Repetitive mild traumatic brain injury (rmTBI) is a prominent public health concern, with linkage to debilitating chronic sequelae. Developing reliable and well-characterized preclinical models of rmTBI is imperative in the investigation of the under
Externí odkaz:
https://doaj.org/article/1f6ea21678784a44a20bd54a3b178dd0
Autor:
Jonathan D. Cherry, Gaoyuan Meng, Sarah Daley, Weiming Xia, Sarah Svirsky, Victor E. Alvarez, Raymond Nicks, Morgan Pothast, Hunter Kelley, Bertrand Huber, Yorghos Tripodis, Michael L. Alosco, Jesse Mez, Ann C. McKee, Thor D. Stein
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background Neuroinflammation has been implicated in the pathogenesis of chronic traumatic encephalopathy (CTE), a progressive neurodegenerative disease association with exposure to repetitive head impacts (RHI) received though playing contac
Externí odkaz:
https://doaj.org/article/f86c5fd4709d442c9de2bc0be5e08412
Autor:
Jonathan D. Cherry, Jesse Mez, John F. Crary, Yorghos Tripodis, Victor E. Alvarez, Ian Mahar, Bertrand R. Huber, Michael L. Alosco, Raymond Nicks, Bobak Abdolmohammadi, Patrick T. Kiernan, Laney Evers, Sarah Svirsky, Katharine Babcock, Hannah M. Gardner, Gaoyuan Meng, Christopher J. Nowinski, Brett M. Martin, Brigid Dwyer, Neil W. Kowall, Robert C. Cantu, Lee E. Goldstein, Douglas I. Katz, Robert A. Stern, Lindsay A. Farrer, Ann C. McKee, Thor D. Stein
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-9 (2018)
Abstract The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodegenerative d
Externí odkaz:
https://doaj.org/article/00003741594643f4996e2555a01e03c7
Autor:
Muriel Arimon, Shuko Takeda, Kathryn L. Post, Sarah Svirsky, Bradley T. Hyman, Oksana Berezovska
Publikováno v:
Neurobiology of Disease, Vol 84, Iss , Pp 109-119 (2015)
Oxidative stress is a common feature of the aging process and of many neurodegenerative disorders, including Alzheimer's disease. Understanding the direct causative relationship between oxidative stress and amyloid pathology, and determining the unde
Externí odkaz:
https://doaj.org/article/30bdfe0f89ca430a87902e8dcc4ac68e
Autor:
Masato Maesako, Jana Horlacher, Katarzyna M Zoltowska, Ksenia V Kastanenka, Eleanna Kara, Sarah Svirsky, Laura J Keller, Xuejing Li, Bradley T Hyman, Brian J Bacskai, Oksana Berezovska
Publikováno v:
eLife, Vol 6 (2017)
The high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its ‘phosphorylated’ and ‘dep
Externí odkaz:
https://doaj.org/article/c7a97664d2b94297b5a3d16d9ec32dbe
Autor:
Bob Jacobs, Riri Uchida, Coby Dodelson, Christine Brzezinski, Hunter Kelley, Matthew Schall, Thor D. Stein, Madeleine E. Garcia, Ann C. McKee, Melissa D. Bauman, Hyunsoo Shin, Sarah Svirsky, Cynthia M. Schumann, N. Beckett Shea-Shumsky, Allyson Alexander, Morgan Pothast, Allysa Warling
Publikováno v:
The Journal of comparative neurology, vol 529, iss 7
J Comp Neurol
J Comp Neurol
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is associated with repetitive head impacts. Neuropathologically, it is defined by the presence of perivascular hyperphosphorylated tau aggregates in cortical tissue (McKee et
Publikováno v:
J Neurotrauma
Traumatic brain injury (TBI) is known to cause short- and long-term synaptic changes in the brain, possibly underlying downstream cognitive impairments. Neuronal levels of neurogranin, a calcium-sensitive calmodulin-binding protein essential for syna
Autor:
Masato Maesako, Sarah Svirsky, Nicole M. Sekula, Laura J. Keller, Oksana Berezovska, Katarzyna Marta Zoltowska
Publikováno v:
Neurobiology of aging
Presenilin 1 (PS1), the catalytic component of gamma secretase, associates with synaptotagmin 1 (Syt-1). This interaction is decreased in the brains of patients with sporadic Alzheimer's disease. However, it remains unclear how this interaction chang
Publikováno v:
Acta Neuropathol
Chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy, is associated with behavioral, mood and cognitive impairment, including dementia. Tauopathies are neurodegenerative diseases whose neuropathological phenotypes are characterized b
Autor:
null Allysa Warling, null Riri Uchida, null Hyunsoo Shin, null Coby Dodelson, null Madeleine E. Garcia, null Noah B. Shea‐Shumsky, null Sarah Svirsky, null Morgan Pothast, null Hunter Kelley, null Cynthia M. Schumann, null Christine Brzezinski, null Melissa D. Bauman, null Allyson Alexander, null Ann C. McKee, null Thor D. Stein, null Matthew Schall, null Bob Jacobs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2965975e1518ba01bb92cd53fa171b8b
https://doi.org/10.1002/cne.25022/v3/response1
https://doi.org/10.1002/cne.25022/v3/response1