Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Sarah Stuart"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Hypoxia-inducible factors (HIFs) are key transcriptional mediators of the hypoxic response and are implicated in oncogenesis. HIFα is regulated by a well-characterized, oxygen-dependent degradation pathway involving the von Hippel Lindau (V
Externí odkaz:
https://doaj.org/article/ecdd9395549d459fa7ba194e75605d7a
Autor:
Justin J. Meade, Sarah Stuart, Jana Neiman-Zenevich, Christian Krustev, Stephen E. Girardin, Jeremy Mogridge
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Cleavage of the innate immune receptor NLRP1B by various microbial proteases causes the proteasomal degradation of its N-terminal fragment and the subsequent release of a C-terminal fragment that forms an inflammasome. We reported previously
Externí odkaz:
https://doaj.org/article/f8ab6aaf55e6414db21260c2820487f1
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The oxygen-labile transcription factor called hypoxia-inducible factor (HIF) is responsible for the cellular and organismal adaptive response to reduced oxygen availability. Deregulation of HIF is associated with the pathogenesis of major hu
Externí odkaz:
https://doaj.org/article/9c2a005093e84756b25673365446edd8
Autor:
Fraser G. Ferens, Cassandra C. Taber, Sarah Stuart, Mia Hubert, Daniel Tarade, Jeffrey E. Lee, Michael Ohh
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Pacak-Zhuang syndrome is caused by mutations in the EPAS1 gene, which encodes for one of the three hypoxia-inducible factor alpha (HIFα) paralogs HIF2α and is associated with defined but varied phenotypic presentations including neuroendoc
Externí odkaz:
https://doaj.org/article/ecd3feb7584042e8b24042291be7574e
Autor:
Sarah Stuart Chewning, David L. Grant, Bridget S. O’Banion, Alexandra D. Gates, Brandon J. Kennedy, Shawn R. Campagna, Sarah L. Lebeis
Publikováno v:
Phytobiomes Journal, Vol 3, Iss 3, Pp 165-176 (2019)
Streptomycetaceae assemble into the internal, root endophytic compartment of a wide variety of plants grown in soils worldwide, suggesting their ability to survive during root microbiome assembly. A previous study found that among four nonpathogenic,
Externí odkaz:
https://doaj.org/article/4f15201c74814ec5a5046853346acd4b
Autor:
Gordon M Cann, Zulfiqar G Gulzar, Samantha Cooper, Robin Li, Shujun Luo, Mai Tat, Sarah Stuart, Gary Schroth, Sandhya Srinivas, Mostafa Ronaghi, James D Brooks, Amirali H Talasaz
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49144 (2012)
Circulating tumor cells (CTC) mediate metastatic spread of many solid tumors and enumeration of CTCs is currently used as a prognostic indicator of survival in metastatic prostate cancer patients. Some evidence suggests that it is possible to derive
Externí odkaz:
https://doaj.org/article/3a9e96b802f243c6b9ee79b29e025b93
Autor:
Toby Andrew, Cassandra D Calloway, Sarah Stuart, Sang Hoon Lee, Raj Gill, Gail Clement, Philip Chowienczyk, Tim D Spector, Ana M Valdes
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22332 (2011)
The mitochondrial theory of ageing proposes that damage to mitochondria and diminished mitochondrial DNA (mtDNA) repair are major contributors to cellular dysfunction and age-related diseases. We investigate the prevalence of heteroplasmy in the mtDN
Externí odkaz:
https://doaj.org/article/acccda3c7bef451fbe3eeae8169618f5
Publikováno v:
Journal of the Academy of Consultation-Liaison Psychiatry. 63:S123-S124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b97d68cb3998181c9cace44061d135fc
https://doi.org/10.1016/j.jaclp.2022.10.026
https://doi.org/10.1016/j.jaclp.2022.10.026
Autor:
Ingrid Grozavu, Sarah Stuart, Anna Lyakisheva, Zhong Yao, Shivanthy Pathmanathan, Michael Ohh, Igor Stagljar
KRAS is one of the most frequently mutated oncogenes in human cancers. Despite nearly 40 years of research, KRAS remains largely undruggable, in part due to an incomplete understanding of its biology. Recently, KRAS dimerization was discovered to pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b466c68e5d19e1f115f1b48e10a2ad05
https://www.bib.irb.hr/1242103
https://www.bib.irb.hr/1242103
Autor:
Claire Wilkinson, Jacob Kyle, Meghna Irimpen, Sarah Stuart, Shylaja Mohandass, Andrew Sheperd, Kathrine J. Smith, Michael J. Mullin
Publikováno v:
Protein Expression and Purification. 198:106125
The Type I Interferon cytokine family member, Interferon-α2b (hIFN-α2b), modulates a number of important biological mechanisms including anti-proliferation, immunoregulation and antiviral responses. Due to its role in the immune system, hIFN-α2b h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ee1e826ae773461b76b2785836e79d
https://doi.org/10.1016/j.pep.2022.106125
https://doi.org/10.1016/j.pep.2022.106125