Zobrazeno 1 - 10
of 502
pro vyhledávání: '"Sarah Spiegel"'
Autor:
Christopher D. Green, Ryan D.R. Brown, Baasanjav Uranbileg, Cynthia Weigel, Sumit Saha, Makoto Kurano, Yutaka Yatomi, Sarah Spiegel
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101971- (2024)
Objective: Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality, and its incidence is increasing due to endemic obesity. HCC is sexually dimorphic in both humans and rodents with higher incidence in males, although the mechan
Externí odkaz:
https://doaj.org/article/0d27976db3474a0b8686c16ec6a18ec0
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100556- (2024)
Niemann-Pick type C1 (NPC1) disease is a rare neurodegenerative cholesterol and sphingolipid storage disorder primarily due to mutations in the cholesterol-trafficking protein NPC1. In addition to catabolic-derived sphingolipids, NPC1 dysfunction als
Externí odkaz:
https://doaj.org/article/c9e835cbc8544d17adb1db991bff1710
Autor:
Ryan D.R. Brown, Christopher D. Green, Cynthia Weigel, Bin Ni, Francesco S. Celi, Richard L. Proia, Sarah Spiegel
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101851- (2024)
Objective: The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) accumulate with overnutrition and have been implicated in non-alcoholic steatohepatitis (NASH) development. ORMDL3, a negative regulator of the rate-limiting
Externí odkaz:
https://doaj.org/article/04df4b65ed0b4cec8e9b5a778f50431d
Autor:
Ingo Fohmann, Alina Weinmann, Fabian Schumacher, Simon Peters, Agata Prell, Cynthia Weigel, Sarah Spiegel, Burkhard Kleuser, Alexandra Schubert-Unkmeir
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011842 (2023)
Invasion of brain endothelial cells (BECs) is central to the pathogenicity of Neisseria meningitidis infection. Here, we established a key role for the bioactive sphingolipid sphingosine-1-phosphate (S1P) and S1P receptor (S1PR) 2 in the uptake proce
Externí odkaz:
https://doaj.org/article/c31e77c4fec344e8933a84ec410cf0cc
Autor:
JASMIN MAHABAMUNUGE, KAYLA MOREL, JOHN BUDROW, INNES TOUNKEL, CASSIDY HART, CAMILLE BRISKIN, MADISON KASOFF, SARAH SPIEGEL, DONALD RISUCCI, JENNIFER KOESTLER
Publikováno v:
Journal of Advances in Medical Education and Professionalism, Vol 9, Iss 4, Pp 189-196 (2021)
Introduction: Medical students self-report insufficient training in topics of gender and sexuality in medicine, which may ultimately lead to negative health outcomes in patients for whom they willprovide care. This study aims to identify whether a st
Externí odkaz:
https://doaj.org/article/7d84c9b747dd42d7b484e0137e69e302
Autor:
Silvia Squillace, Michael L. Niehoff, Timothy M. Doyle, Michael Green, Emanuela Esposito, Salvatore Cuzzocrea, Christopher K. Arnatt, Sarah Spiegel, Susan A. Farr, Daniela Salvemini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
Cancer-related cognitive impairment (CRCI) is a major neurotoxicity affecting more than 50% of cancer survivors. The underpinning mechanisms are mostly unknown, and there are no FDA-approved interventions. Sphingolipidomic analysis of mouse prefronta
Externí odkaz:
https://doaj.org/article/1997f1a57945403ea08d3af60277e069
Autor:
David Montefusco, Maryam Jamil, Melissa A. Maczis, William Schroeder, Moshe Levi, Suman Ranjit, Jeremy Allegood, Dipankar Bandyopadhyay, Reuben Retnam, Sarah Spiegel, L. Ashley Cowart
Publikováno v:
Molecular Metabolism, Vol 62, Iss , Pp 101523- (2022)
Objective: Men with non-alcoholic fatty liver disease (NAFLD) are more likely to progress to non-alcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of this dimorphism is unclear. We have previ
Externí odkaz:
https://doaj.org/article/36b4fda04a2243168e4f494f47289685
Autor:
Timothy M. Doyle, Mark R. Hutchinson, Kathryn Braden, Kali Janes, Vicky Staikopoulos, Zhoumou Chen, William L. Neumann, Sarah Spiegel, Daniela Salvemini
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-8 (2020)
Abstract Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 r
Externí odkaz:
https://doaj.org/article/aa30603a92e14637a5ad0de991f3f7b6
Autor:
Timothy D. Rohrbach, April E. Boyd, Pamela J. Grizzard, Sarah Spiegel, Jeremy Allegood, Santiago Lima
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 953-967 (2020)
MS-assisted lipidomic tissue analysis is a valuable tool to assess sphingolipid metabolism dysfunction in disease. These analyses can reveal potential pharmacological targets or direct mechanistic studies to better understand the molecular underpinni
Externí odkaz:
https://doaj.org/article/2d2587a90f85415790e84a5fca109808
Autor:
Li-Pin Kao, Samy A.F. Morad, Traci S. Davis, Matthew R. MacDougall, Miki Kassai, Noha Abdelmageed, Todd E. Fox, Mark Kester, Thomas P. Loughran, Jr., Jose' L. Abad, Gemma Fabrias, Su-Fern Tan, David J. Feith, David F. Claxton, Sarah Spiegel, Kelsey H. Fisher-Wellman, Myles C. Cabot
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1590-1602 (2019)
The combination of daunorubicin (dnr) and cytarabine (Ara-C) is a cornerstone of treatment for acute myelogenous leukemia (AML); resistance to these drugs is a major cause of treatment failure. Ceramide, a sphingolipid (SL), plays a critical role in
Externí odkaz:
https://doaj.org/article/fd54fe2e27784a42b78f98d42562f8fa