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pro vyhledávání: '"Sarah Siska"'
Autor:
Jie Shi, Vinayak Hosagrahara, Keith A. Koch, Lihua Yang, Dillon Phan, Hansjoerg Lehmann, Ophelia Ardayfio, Olga Rozhitskaya, Sarah Siska, Maurice Van Eis, Ming Qian, Taeyoung Yoon, Timothy A. McKinsey, Kimberly Beattie, Craig F. Plato, Lauren G. Monovich, Clayton Springer, Margaret R. Pancost, Anup Patnaik, Erik Meredith, Ji-Hu Zhang, Istvan J. Enyedy, Anette Von Matt, Vasumathy Rajaraman, Richard B. Vega, Wendy Lee, Nikos Pagratis, Karl Miranda, Christoph Gaul, Markus Dobler, Chang Rao, Thomas Ruppen, Na Zhu, Charles F. Jewell
Publikováno v:
Journal of Medicinal Chemistry. 53:5400-5421
A novel 2,6-naphthyridine was identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor. PKD inhibition in the heart was proposed as a potential antihypertrophic mechanism with application as a heart failure therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643c1eb2e5cd66e32ad8af6e6eca9317
https://doi.org/10.1021/jm100075z
https://doi.org/10.1021/jm100075z
