A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

Autor: Eric WFW Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield, Diana Bilton, Emily V Bloomfield, A Christopher Boyd, June Brand, Ruaridh Buchan, Roberto Calcedo, Paula Carvelli, Mario Chan, Seng H Cheng, David S Collie, Steve Cunningham, Heather E Davidson, Gwyneth Davies, Jane C Davies, Lee A Davies, Maria H Dewar, Ann Doherty, Jackie Donovan, Natalie S Dwyer, Hala I Elgmati, Rosanna F Featherstone, Jemyr Gavino, Sabrina Gea-Sorli, Duncan M Geddes, James SR Gibson, Deborah R Gill, Andrew P Greening, Uta Griesenbach, David M Hansell, Katharine Harman, Tracy E Higgins, Samantha L Hodges, Stephen C Hyde, Laura Hyndman, J Alastair Innes, Joseph Jacob, Nancy Jones, Brian F Keogh, Maria P Limberis, Paul Lloyd-Evans, Alan W Maclean, Michelle C Manvell, Dominique McCormick, Michael McGovern, Gerry McLachlan, Cuixiang Meng, M Angeles Montero, Hazel Milligan, Laura J Moyce, Gordon D Murray, Andrew G Nicholson, Tina Osadolor, Javier Parra-Leiton, David J Porteous, Ian A Pringle, Emma K Punch, Kamila M Pytel, Alexandra L Quittner, Gina Rivellini, Clare J Saunders, Ronald K Scheule, Sarah Sheard, Nicholas J Simmonds, Keith Smith, Stephen N Smith, Najwa Soussi, Samia Soussi, Emma J Spearing, Barbara J Stevenson, Stephanie G Sumner-Jones, Minna Turkkila, Rosa P Ureta, Michael D Waller, Marguerite Y Wasowicz, James M Wilson, Paul Wolstenholme-Hogg, on behalf of the UK Cystic Fibrosis Gene Therapy Consortium

Publikováno v: Efficacy and Mechanism Evaluation, Vol 3, Iss 5 (2016)

Background: Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene leading to abnormal airway surface ion transport, chronic lung infections, inflammation and eventual re

Externí odkaz: https://doaj.org/article/09b29fe1b155492fba24a177fe4be24c

A Guide for Systems Engineers to Finding Your Role in 21 st ‐Century Software‐Dominant Organizations

Autor: Kenneth E. Nidiffer, Macaulay Osaisai, Mickael Bouyaud, Jeannine Siviy, Sarah Sheard

Publikováno v: INCOSE International Symposium. 31:926-941

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24a47aff4bee650ac3cba832bf6dfd96
https://doi.org/10.1002/j.2334-5837.2021.00878.x

'Book Club' Guides A Working Group to Create INCOSE System‐Software Interface Products

Autor: Mickael Bouyaud, Macaulay Osaisai, Ken Nidiffer, Jeannine Siviy, Sarah Sheard

Publikováno v: INSIGHT. 24:17-20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4a432e1416e15222e2cfa65e8b1b77a
https://doi.org/10.1002/inst.12335

Systems Engineering–Software Engineering Interface for Cyber‐Physical Systems

Autor: Michael E. Pafford, Sarah Sheard, Mike Phillips

Publikováno v: INCOSE International Symposium. 29:249-268

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8063adfe6df7b02f56fd0e162781e2ab
https://doi.org/10.1002/j.2334-5837.2019.00602.x

Vascular and Parenchymal Enhancement Assessment by Dual-Phase Dual-Energy CT in the Diagnostic Investigation of Pulmonary Hypertension

Autor: Jenny Louise Bacon, Charles Sayer, Sarah Sheard, Ioannis Vlahos, Conor Gissane, Brendan Patrick Madden

Publikováno v: Radiol Cardiothorac Imaging

PURPOSE: To evaluate pulmonary hypertension (PH) determination by dual-phase dual-energy CT pulmonary angiography vascular enhancement and perfused blood volume (PBV) quantification. MATERIALS AND METHODS: In this prospective study, consecutive parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938e195b560e545a96cb31df7d6758e2
https://europepmc.org/articles/PMC7977698/