Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sarah Schramke"'
Autor:
Verena Schuldenzucker, Robin Schubert, Lisa M Muratori, Frauke Freisfeld, Lorena Rieke, Tamara Matheis, Sarah Schramke, Jan Motlik, Nicole Kemper, Ute Radespiel, Ralf Reilmann
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185970 (2017)
Large animal models of Huntington's disease (HD) may increase the reliability of translating preclinical findings to humans. Long live expectancy offers opportunities particularly for disease modifying approaches, but also challenges. The transgenic
Externí odkaz:
https://doaj.org/article/3cd3ab1d22f94713afea4989de5fa3be
Autor:
Robin Schubert, Jan Motlik, Sarah Schramke, Verena Schuldenzucker, Ralf Reilmann, Tamara Matheis, Frauke Freisfeld, Lisa M. Muratori, Nicole Kemper, Lorena Rieke, Ute Radespiel
Publikováno v:
Journal of Huntington's Disease. 7:151-161
BACKGROUND Huntington's disease (HD) is an autosomal-dominant, progressive neurodegenerative disorder with motor, cognitive, behavioral and metabolic symptoms. HD patients exhibit an altered response to stress which is reflected in changes of cortiso
Autor:
Jan Motlik, Stefanie Ott, Eun Young Kim, Ralf Reilmann, M Wirsig, Sarah Schramke, E Hölzner, Robin Schubert, Hans J. Johnson, Nina Nagelmann, Cornelius Faber, Verena Schuldenzucker, Frauke Frank, Lennart Liebsch, Sergej O. Demokritov
Publikováno v:
Journal of Neuroscience Methods. 265:46-55
Background As novel treatment approaches for Huntington's disease (HD) evolve, the use of transgenic (tg) large animal models has been considered for preclinical safety and efficacy assessments. It is hoped that large animal models may provide higher
Autor:
Robin Schubert, Ralf Reilmann, Frauke Frank, M Wirsig, Nicole Kemper, Michaela Fels, Sarah Schramke, Verena Schuldenzucker
Publikováno v:
Česká a slovenská neurologie a neurochirurgie. :55-60
Autor:
Sarah Schramke, Robin Schubert, Michaela Fels, Lorena Rieke, Ralf Reilmann, Tamara Matheis, Nicole Kemper, Lisa M. Muratori, Verena Schuldenzucker, Jan Motlik
Publikováno v:
Journal of Huntington's disease. 7(3)
BACKGROUND Large animal models, such as the transgenic (tg) Huntington disease (HD) minipig, have been proposed to improve translational reliability and assessment of safety, efficacy and tolerability in preclinical studies. Minipigs are characterise
Autor:
Nicole Kemper, Verena Schuldenzucker, Frauke Freisfeld, Robin Schubert, Jan Motlik, Ute Radespiel, Tamara Matheis, Ralf Reilmann, Sarah Schramke, Lorena Rieke, Lisa M. Muratori
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185970 (2017)
PLoS ONE
PLoS ONE
Background Large animal models of Huntington’s disease (HD) may increase the reliability of translating preclinical findings to humans. Long live expectancy offers opportunities particularly for disease modifying approaches, but also challenges. Th
Autor:
Michaela Fels, Stefanie Ott, Verena Schuldenzucker, Robin Schubert, Ralf Reilmann, E Hölzner, Nicole Kemper, Frauke Frank, M Wirsig, Sarah Schramke, Jan Motlik
Publikováno v:
Journal of neuroscience methods. 265
Background While several novel therapeutic approaches for HD are in development, resources to conduct clinical trials are limited. Large animal models have been proposed to improve assessment of safety, tolerability and especially to increase transla
Autor:
Tamara Matheis, Frauke Freisfeld, Hans J. Johnson, Nina Nagelmann, Eun Young Kim, Robin Schubert, Sarah Schramke, Jan Motlik, M Wirsig, Verena Schuldenzucker, Cornelius Faber, Ralf Reilmann, Lorena Rieke
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A32.1-A32
Background In the TRACK tgHD minipig study, we aim to track longitudinal progression of the Libechov minipig, transgenic for the huntingtin gene. Annual MRI scans are conducted, including anatomical, spectroscopic and diffusion weighted imaging (DWI)
Autor:
Robin Schubert, Ralf Reilmann, Tamara Matheis, Sarah Schramke, Lorena Rieke, Verena Schuldenzucker, Frauke Freisfeld, Jan Motlik
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A31.3-A32
Background Transgenic (tg) minipigs (124 Q) serve as large animal model for pre-clinical studies in HD. Several studies showed a higher cortisol level in HD patients in comparison to control groups. We therefore developed a “Stress Level Test” as
Autor:
Verena Schuldenzucker, Frauke Freisfeld, Jan Motlik, Tamara Matheis, Robin Schubert, Ralf Reilmann, Lorena Rieke, Sarah Schramke
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A31.1-A31
Backround The Libechov tgHD minipig model is currently translated to first preclinical studies in HD. We here introduce a new semi-automated setup of the discrimination test as part of an assessment battery for phenotyping minipigs. The discriminatio