In Vitro Nephrotoxicity Studies of Established and Experimental Platinum-Based Compounds

Autor: Sarah Schoch, Vasily Sen, Walburgis Brenner, Andrea Hartwig, Beate Köberle

Publikováno v: Biomedicines, Vol 9, Iss 8, p 1033 (2021)

Cisplatin is one of the most commonly used drugs for the treatment of various solid cancers. However, its efficacy is restricted by severe side effects, especially dose-limiting nephrotoxicity. New platinum-based compounds are designed to overcome th

Externí odkaz: https://doaj.org/article/12409681554c46018ef0c98d0c12027d

Identification and validation of NFIA as a novel prognostic marker in renal cell carcinoma

Autor: Roger de Alwis, Sarah Schoch, Mazharul Islam, Christina Möller, Börje Ljungberg, Håkan Axelson

Publikováno v: The Journal of Pathology: Clinical Research.

Prognostic tools are an essential component of the clinical management of patients with renal cell carcinoma (RCC). Although tumour stage and grade can provide important information, they fail to consider patient- and tumour-specific biology. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b4af958c5622326258396705466d4b
https://doi.org/10.1002/cjp2.316

Size-based isolation and detection of renal carcinoma cells from whole blood

Autor: Roger, De Alwis, Jennifer, Hansson, David, Lindgren, Sarah, Schoch, Alexander, Tejera, Bianca, Scholtz, Peter, Elfving, Christina, Möller, Helén, Nilsson, Martin, Johansson, Håkan, Axelson

Publikováno v: Molecular and clinical oncology. 16(5)

Renal cell carcinoma (RCC) is a tumour type with an indolent growth pattern and rather vague symptoms. The present study developed a platform for liquid biopsy of RCC based upon the isolation of circulating tumour cells (CTCs). Founded on the observa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::110f48d485470f034961c580a3c23685
https://pubmed.ncbi.nlm.nih.gov/35463211

Comparative Study of the Mode of Action of Clinically Approved Platinum-Based Chemotherapeutics

Autor: Sarah, Schoch, Sabine, Gajewski, Jana, Rothfuß, Andrea, Hartwig, Beate, Köberle

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 6928, p 6928 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 18
International journal of molecular sciences, 21 (18), Art. Nr.: 6928

Platinum drugs are among the most effective anticancer agents, but their mode of action is still not fully understood. We therefore carried out a systematic investigation on the cellular activities of cisplatin, carboplatin and oxaliplatin in A498 ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142f2300494acae26f837cb01c0d5abe
https://www.mdpi.com/1422-0067/21/18/6928

Activity profile of the cisplatin analogue PN149 in different tumor cell lines

Autor: Beate Köberle, Bettina Maria Strauch, Valery G. Golubev, Andrea Hartwig, Sabine Gajewski, Vasily D. Sen, Sarah Schoch

Publikováno v: Biochemical Pharmacology. 156:109-119

The efficacy of the anticancer drug cisplatin is restricted by tumor cell resistance and occurrence of severe side effects. One strategy to overcome these limitations is the development of new, improved platinum drugs. Previous investigations showed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f15462e46c5632a29e45d47888336c
https://doi.org/10.1016/j.bcp.2018.08.025