Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.

Autor: Emma Colucci-Guyon, Aline Rifflet, Sarah Saint-Auret, Anaëlle da Costa, Laurent Boucontet, Thomas Laval, Christophe Prehaud, Nicolas Blanchard, Jean-Pierre Levraud, Ivo G Boneca, Caroline Demangel, Laure Guenin-Macé

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008878 (2020)

Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU) disease, is unique amongst human pathogens in its capacity to produce a lipid toxin called mycolactone. While previous studies have demonstrated that bacterially-released mycolactone di

Externí odkaz: https://doaj.org/article/26282b15277245c594cb443803d75fe7

Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system

Autor: Thomas Laval, Sarah Saint-Auret, Ivo G. Boneca, Laurent Boucontet, Caroline Demangel, Jean-Pierre Levraud, Laure Guenin-Macé, Christophe Prehaud, Anaelle da Costa, Emma Colucci-Guyon, Aline Rifflet, Nicolas Blanchard

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008878 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (12), pp.e0008878. ⟨10.1371/journal.pntd.0008878⟩
PLoS Neglected Tropical Diseases, 2020, 14 (12), pp.e0008878. ⟨10.1371/journal.pntd.0008878⟩

Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU) disease, is unique amongst human pathogens in its capacity to produce a lipid toxin called mycolactone. While previous studies have demonstrated that bacterially-released mycolactone di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ff524e2850e7ca4484b259cbe51f7e
https://doaj.org/article/26282b15277245c594cb443803d75fe7

2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design

Autor: Marcel Kaiser, Wolfgang Haap, Sarah Saint-Auret, Franz Schuler, Tanja Schirmeister, Rainer E. Martin, François Diederich, Bernd Kuhn, Reto Brun, Maude Giroud, Christoph Kuratli

Publikováno v: Journal of medicinal chemistry. 61(8)

Macrocyclic inhibitors of rhodesain (RD), a parasitic cysteine protease and drug target for the treatment of human African trypanosomiasis, have shown low metabolic stability at the macrocyclic ether bridge. A series of acyclic dipeptidyl nitriles wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e38b587936fa2ab1c226e5733b2478e
https://pubmed.ncbi.nlm.nih.gov/29590751

Modular total syntheses of mycolactone A/B and its [

Autor: Sarah, Saint-Auret, Hajer, Abdelkafi, Didier, Le Nouen, Laure, Guenin-Macé, Caroline, Demangel, Philippe, Bisseret, Nicolas, Blanchard

Publikováno v: Organicbiomolecular chemistry. 15(36)

A modular total synthesis of mycolactone A/B, the exotoxin produced by Mycobacterium ulcerans, has been achieved through the orchestration of several Pd-catalyzed key steps. While this route leads to a mixture of the natural product and its C12 epime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9225599df958e7fbe8d2a8d646d8c5c
https://pubmed.ncbi.nlm.nih.gov/28871293

Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans

Autor: Nicolas Blanchard, Philippe Bisseret, Sarah Saint-Auret, Hajer Abdelkafi, Didier Le Nouen

Publikováno v: Organic Chemistry Frontiers
Organic Chemistry Frontiers, Royal Society of Chemistry, 2017, 4, pp.2380-2386. ⟨10.1039/C7QO00608J⟩

Mycolactone A/B, a complex polyketidic macrolide secreted by Mycobacterium ulcerans, has been synthesized using catalytic and/or asymmetric reactions. Several palladium-catalyzed reactions were investigated for forging key σ-bonds as well as a parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e8e33f02c844733c475894bdaf5284
https://hal.archives-ouvertes.fr/hal-02153057