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Akademický článek

Modern simulation utilities for genetic analysis

Autor: Sarah S. Ji, Christopher A. German, Kenneth Lange, Janet S. Sinsheimer, Hua Zhou, Jin Zhou, Eric M. Sobel

Publikováno v: BMC Bioinformatics, Vol 22, Iss 1, Pp 1-13 (2021)

Abstract Background Statistical geneticists employ simulation to estimate the power of proposed studies, test new analysis tools, and evaluate properties of causal models. Although there are existing trait simulators, there is ample room for moderniz

Externí odkaz: https://doaj.org/article/3207b3d528f54481a8504f812aa9c433

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Modern simulation utilities for genetic analysis

Autor: Christopher A. German, Hua Zhou, Janet S. Sinsheimer, Jin Zhou, Kenneth Lange, Eric M. Sobel, Sarah S. Ji

Publikováno v: BMC bioinformatics, vol 22, iss 1
BMC Bioinformatics
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-13 (2021)

Background Statistical geneticists employ simulation to estimate the power of proposed studies, test new analysis tools, and evaluate properties of causal models. Although there are existing trait simulators, there is ample room for modernization. Fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0bb9bf581faf02531fedc278b0621d
https://escholarship.org/uc/item/28p2n2bx

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Akademický článek

Reemergence of Bordetella parapertussis, United States, 2019–2023

Autor: Brooklyn A. Noble, Sarah S. Jiudice, Jay D. Jones, Tristan T. Timbrook

Publikováno v: Emerging Infectious Diseases, Vol 30, Iss 5, Pp 1058-1060 (2024)

To determine changes in Bordetella pertussis and B. parapertussis detection rates, we analyzed 1.43 million respiratory multiplex PCR test results from US facilities from 2019 through mid-2023. From mid-2022 through mid-2023, Bordetella spp. detectio

Externí odkaz: https://doaj.org/article/91eecafb01fe48b084c65ed521f136f6

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A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders

Autor: Andrew J. Levine, Janet S. Sinsheimer, Elyse J. Singer, Eliezer Masliah, David J. Moore, Virawudh Soontornniyomkij, Steve Horvath, Asha R. Kallianpur, Sarah S. Ji

Publikováno v: Journal of neurovirology, vol 26, iss 4

HIV-associated neurocognitive disorders (HAND) describe a spectrum of neuropsychological impairment caused by HIV-1 infection. While the sequence of cellular and physiological events that lead to HAND remains obscure, it likely involves chronic neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1658e8e80f985fc867e298f3587d7680
https://escholarship.org/uc/item/58m8w5dt

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Correction to: A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders

Autor: Eliezer Masliah, Janet S. Sinsheimer, Steve Horvath, Asha R. Kallianpur, Virawudh Soontornniyomkij, Andrew J. Levine, David J. Moore, Sarah S. Ji, Elyse J. Singer

Publikováno v: J Neurovirol

BACKGROUND: HIV-associated neurocognitive disorders (HAND) describe a spectrum of neuropsychological impairment caused by HIV-1 infection. While the sequence of cellular and physiological events that lead to HAND remains obscure, it likely involves c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2a5483d1e0e4509a62d0b3c6b9d736
https://pubmed.ncbi.nlm.nih.gov/32394397

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OPENMENDEL: a cooperative programming project for statistical genetics

Autor: Jing Zhai, Benjamin B. Chu, Janet S. Sinsheimer, Gordon D. Mosher, Christopher A. German, Kenneth Lange, Jin Zhou, Juhyun Kim, Eric M. Sobel, Douglas M. Bates, Hua Zhou, Sarah S. Ji, Jeanette C. Papp, Kevin L. Keys, Seyoon Ko

Publikováno v: Zhou, Hua; Sinsheimer, Janet S; Bates, Douglas M; Chu, Benjamin B; German, Christopher A; Ji, Sarah S; et al.(2019). OPENMENDEL: a cooperative programming project for statistical genetics.. Human genetics. doi: 10.1007/s00439-019-02001-z. UCLA: Retrieved from: http://www.escholarship.org/uc/item/06k1386p
Human genetics, vol 139, iss 1
Hum Genet

Statistical methods for genomewide association studies (GWAS) continue to improve. However, the increasing volume and variety of genetic and genomic data make computational speed and ease of data manipulation mandatory in future software. In our view

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66124d43f3accb1720240474a0b71954
http://www.escholarship.org/uc/item/06k1386p

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Activity of Genes with Functions in Human Williams-Beuren Syndrome Is Impacted by Mobile Element Insertions in the Gray Wolf Genome

Autor: Matthew L. Aardema, Sarah S. Ji, Bridgett M. vonHoldt, Daniel R. Stahler, Monique A. R. Udell, Janet S. Sinsheimer

Publikováno v: Genome biology and evolution, vol 10, iss 6
Genome Biology and Evolution

In canines, transposon dynamics have been associated with a hyper-social behavioral syndrome, although the functional mechanism has yet to be described. We investigate the epigenetic and transcriptional consequences of these behavior-associated mobil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede9c22cbe56786ac26c278d75b4b187
https://escholarship.org/uc/item/1vq6m5mx

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