Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sarah S. Darwish"'
Autor:
Sarah S. Darwish, Po-Jen Chen, Mostafa M. Hamed, Reem A. Wagdy, Shun-Hua Chen, Ashraf H. Abadi, Mohammad Abdel-Halim, Tsong-Long Hwang, Matthias Engel
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 778 (2022)
For many inflammatory diseases, new effective drugs with fewer side effects are needed. While it appears promising to target the activation of the central pro-inflammatory transcription factor NF-κB, many previously discovered agents suffered from c
Externí odkaz:
https://doaj.org/article/4f94eed140294a279c7ecbceba04a02c
Autor:
Reem A. Wagdy, Po-Jen Chen, Mostafa M. Hamed, Sarah S. Darwish, Shun-Hua Chen, Ashraf H. Abadi, Mohammad Abdel-Halim, Tsong-Long Hwang, Matthias Engel
Publikováno v:
Bioorganic Chemistry. 127:105977
The transcription factor NF-κB is a pivotal mediator of chronic inflammatory and autoimmune diseases. Based on our previously published dual EGFR/NF-κB inhibitors, we designed and synthesized new thiourea quinazoline derivatives that retained only
Autor:
Malakeh Z. Malak, Dalal Yehia, Rawan R. Awad, Nancy N. Al-Thwabih, Enas S. Al-Ajouri, Sarah S. Darwish, Amnah S. Hamad
Publikováno v:
Perspectives in Psychiatric Care. 56:46-53
PURPOSE The study aimed to assess the correlation between fatigue and psychological factors, namely stress, social support, self-esteem, and depression among pregnant women in Jordan. DESIGN AND METHODS A cross-sectional design was suggested. Cluster
Autor:
Mohamed Salah, Mohammad Abdel-Halim, Matthias Engel, Walter Becker, Ashraf H. Abadi, Sarah S. Darwish
Publikováno v:
European Journal of Medicinal Chemistry. 157:1031-1050
The protein kinase Dyrk1A modulates several processes relevant to the development or progression of Alzheimer's disease (AD), e. g. through phosphorylation of tau protein, amyloid precursor protein (APP) as well as proteins involved in the regulation
Autor:
Sarah S. Darwish, Ahmed K. ElHady, Mohamed Salah, Walter Becker, Matthias Engel, Ashraf H. Abadi, Mohammad Abdel-Halim
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) is a potential target in Alzheimer's disease (AD) because of the established correlation between its over-expression and generation of neurofibrillary tangles (NFT) as well as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b322e60d2576caf53adfec08a64bcfd
Publikováno v:
Journal of medicinal chemistry. 60(7)
The activation of the NF-κB transcription factor is a major adaptive response induced upon treatment with EGFR kinase inhibitors, leading to the emergence of resistance in nonsmall cell lung cancer and other tumor types. To suppress this survival me
Autor:
Rolf W. Hartmann, Jessica Hoppstädter, Alexandra K. Kiemer, Ashraf H. Abadi, Ahmed K. ElHady, Mohammad Abdel-Halim, Matthias Engel, Sarah S. Darwish
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 93
The protein kinase PKCζ is involved in the fine regulation of the NF-κB transcriptional activity and, therefore, represents a potential pharmacological target in inflammatory diseases. We previously developed a selective, allosteric inhibitor (MA13
Autor:
Saleh T; The Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan., Bloukh S; Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan., Carpenter VJ; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23284, USA., Alwohoush E; Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan., Bakeer J; Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan., Darwish S; The Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan., Azab B; Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.; Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23284, USA., Gewirtz DA; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23284, USA.
Publikováno v:
Cancers [Cancers (Basel)] 2020 Mar 29; Vol. 12 (4). Date of Electronic Publication: 2020 Mar 29.
Autor:
Bener A; Department of Medical Statistics and Epidemiology, Hamad Medical Corporation, London, UK ; Department of Public Health, Weill Cornell Medical College, Doha, Qatar, London, UK ; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, The University of Manchester, Manchester, UK., Darwish S; Department of Endocrinology, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar, London, UK., Al-Hamaq AO; Department of Qatar Diabetic Association and Qatar Foundation, Doha, Qatar, London, UK., Yousafzai MT; Department of Medical Statistics and Epidemiology, Hamad Medical Corporation, London, UK ; Department of Public Health, Weill Cornell Medical College, Doha, Qatar, London, UK., Nasralla EA; Division of Epidemiology and Public Health, Imperial College London, London, UK.
Publikováno v:
Indian journal of endocrinology and metabolism [Indian J Endocrinol Metab] 2014 Mar; Vol. 18 (2), pp. 202-9.
Autor:
Bener A; Department of Medical Statistics and Epidemiology, Hamad Medical Corporation, Department of Public Health, Weill Cornell Medical College, Doha, Qatar ; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester, UK., Darwish S, Al-Hamaq AO, Mohammad RM, Yousafzai MT
Publikováno v:
The application of clinical genetics [Appl Clin Genet] 2013 Oct 24; Vol. 6, pp. 103-11. Date of Electronic Publication: 2013 Oct 24 (Print Publication: 2013).