Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sarah S J Rewell"'
Autor:
Sarah S J Rewell, Leonid Churilov, T Kate Sidon, Elena Aleksoska, Susan F Cox, Malcolm R Macleod, David W Howells
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171688 (2017)
Key disparities between the timing and methods of assessment in animal stroke studies and clinical trial may be part of the reason for the failure to translate promising findings. This study investigates the development of ischemic damage after threa
Externí odkaz:
https://doaj.org/article/6364cbbb176a40409b51d696e573b594
Autor:
Ali Shad, Sarah S. J. Rewell, Matthew Macowan, Natasha Gandasasmita, Jiping Wang, Ke Chen, Ben Marsland, Terence J. O’Brien, Jian Li, Bridgette D. Semple
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Pneumonia is a common comorbidity in patients with severe traumatic brain injury (TBI), and is associated with increased morbidity and mortality. In this study, we established a model of intratracheal Klebsiella pneumoniae administration in
Externí odkaz:
https://doaj.org/article/7b58397417fe4ee48e3768b3f6e4cf39
Autor:
Gary P. Morris, Emma K. Gowing, Jo‐Maree Courtney, Hannah E. Coombe, Natalie E. King, Sarah S. J. Rewell, David W. Howells, Andrew N. Clarkson, Brad A. Sutherland
Publikováno v:
Journal of Neuroscience Research. 101:278-292
Stroke therapy has largely focused on preventing damage and encouraging repair outside the ischemic core, as the core is considered irreparable. Recently, several studies have suggested endogenous responses within the core are important for limiting
Autor:
John A Fernandez, David W. Howells, Elena Aleksoska, Leonid Churilov, Steven A Sastra, Susan F Cox, Malcolm R. Macleod, H. Bart van der Worp, Sarah S J Rewell, Amy L. Jeffreys
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 37:3380-3390
To assess the true effect of novel therapies for ischaemic stroke, a positive control that can validate the experimental model and design is vital. Hypothermia may be a good candidate for such a positive control, given the convincing body of evidence
Autor:
Helen M Dewey, Sarah S. J. Rewell, Stephen A. Sastra, Geoffrey A. Donnan, Amy L. Jeffreys, Jenny Margaret Favaloro, David W. Howells, William Wilson, Linda J. Lockett, Marie Dagonnier
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206321 (2018)
PLoS ONE
PLoS ONE
Stroke evolution is a highly dynamic but variable disease which makes clinical decision making difficult. Biomarker discovery programs intended to aid clinical decision making have however largely ignored the rapidity of stroke evolution. We have use
Autor:
Leonid Churilov, Elena Aleksoska, T. Kate Sidon, Sarah S. J. Rewell, Susan F Cox, David W. Howells, Malcolm R. Macleod
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171688 (2017)
Rewell, S S J, Churilov, L, Sidon, T K, Aleksoska, E, Cox, S F, Macleod, M R, Howells, D W & Minnerup, J (ed.) 2017, ' Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials ', PLoS ONE, vol. 12, no. 2, pp. e0171688 . https://doi.org/10.1371/journal.pone.0171688
PLoS ONE
Rewell, S S J, Churilov, L, Sidon, T K, Aleksoska, E, Cox, S F, Macleod, M R, Howells, D W & Minnerup, J (ed.) 2017, ' Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials ', PLoS ONE, vol. 12, no. 2, pp. e0171688 . https://doi.org/10.1371/journal.pone.0171688
PLoS ONE
Key disparities between the timing and methods of assessment in animal stroke studies and clinical trial may be part of the reason for the failure to translate promising findings. This study investigates the development of ischemic damage after threa
Autor:
Sarah S. J. Rewell, David W. Howells
Publikováno v:
Springer Series in Translational Stroke Research ISBN: 9783319453446
This chapter will discuss the variability in infarct size after ischaemic stroke in rat models of stroke, drawing example from our experience with the thread occlusion model. We will describe how the neuroprotective effect of a novel treatment dimini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e0afbc50c344e0f0dd336dd3ededbe5
https://doi.org/10.1007/978-3-319-45345-3_28
https://doi.org/10.1007/978-3-319-45345-3_28
Autor:
David W. Howells, Ali Ghasem-Zadeh, Karen Borschmann, Rachel A Davey, Sarah S. J. Rewell, Julie Bernhardt, Heidi Ho, Sandra Iuliano, Peta Skeers
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172889 (2017)
PLoS ONE
PLoS ONE
Background: Immobility and neural damage likely contribute to accelerated bone loss after stroke, and subsequent heightened fracture risk in humans. Objective: To investigate the skeletal effect of middle cerebral artery occlusion (MCAo) stroke in ra
Autor:
H. Bart van der Worp, Peter E. Batchelor, Amy L. Jeffreys, Leonid Churilov, Susan F Cox, Malcolm R. Macleod, Emily S. Sena, David W. Howells, Stephen A. Sastra, Sarah S J Rewell
Publikováno v:
International Journal of Stroke. 8:180-185
Background Hypothermia is a promising experimental treatment for acute ischemic stroke. Human trials are still at an early stage, with the focus now on using hypothermia in awake patients. Pethidine (meperidine) is the principle agent used to control
Publikováno v:
International Journal of Stroke. 7:386-397
The main driving force behind the assessment of novel pharmacological agents in animal models of stroke is to deliver new drugs to treat the human disease rather than to increase knowledge of stroke pathophysiology. There are numerous animal models o