Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Sarah Rennie"'
Autor:
Sarah Rennie
Publikováno v:
Genes, Vol 15, Iss 5, p 629 (2024)
RNA-binding proteins and chemical modifications to RNA play vital roles in the co- and post-transcriptional regulation of genes. In order to fully decipher their biological roles, it is an essential task to catalogue their precise target locations al
Externí odkaz:
https://doaj.org/article/a899bfa56aac4c328841c70041e844c5
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 7, Pp n/a-n/a (2023)
Abstract Many genes are co‐expressed and form genomic domains of coordinated gene activity. However, the regulatory determinants of domain co‐activity remain unclear. Here, we leverage human individual variation in gene expression to characterize
Externí odkaz:
https://doaj.org/article/c0ff0e72b3834be1a2a4a6dc42af6a37
Autor:
Na Qian, Rebecca Distefano, Mirolyuba Ilieva, Jens Hedelund Madsen, Sarah Rennie, Shizuka Uchida
Publikováno v:
Non-Coding RNA, Vol 9, Iss 5, p 50 (2023)
The NLRP3 inflammasome plays a pivotal role in regulating inflammation and immune responses. Its activation can lead to an inflammatory response and pyroptotic cell death. This is beneficial in the case of infections, but excessive activation can lea
Externí odkaz:
https://doaj.org/article/944cb221c05a461ba094a3f346fcbbb6
Publikováno v:
BioTech, Vol 12, Iss 3, p 56 (2023)
RNA, like DNA and proteins, can undergo modifications. To date, over 170 RNA modifications have been identified, leading to the emergence of a new research area known as epitranscriptomics. RNA editing is the most frequent RNA modification in mammali
Externí odkaz:
https://doaj.org/article/67bd5f62f3994a49834d25997ec4973a
Autor:
Hjörleifur Einarsson, Marco Salvatore, Christian Vaagensø, Nicolas Alcaraz, Jette Bornholdt, Sarah Rennie, Robin Andersson
Publikováno v:
eLife, Vol 11 (2022)
Genetic and environmental exposures cause variability in gene expression. Although most genes are affected in a population, their effect sizes vary greatly, indicating the existence of regulatory mechanisms that could amplify or attenuate expression
Externí odkaz:
https://doaj.org/article/3708e44055a64355b43d5ce5d53dcc73
Publikováno v:
Non-Coding RNA, Vol 9, Iss 4, p 39 (2023)
Cancer and cardiovascular disease are the leading causes of death worldwide. Recent evidence suggests that these two life-threatening diseases share several features in disease progression, such as angiogenesis, fibrosis, and immune responses. This h
Externí odkaz:
https://doaj.org/article/8193ed5579d24a02beb2256720157bfa
Autor:
Rebecca Distefano, Mirolyuba Ilieva, Jens Hedelund Madsen, Hideshi Ishii, Masanori Aikawa, Sarah Rennie, Shizuka Uchida
Publikováno v:
Non-Coding RNA, Vol 9, Iss 3, p 30 (2023)
Type II diabetes (T2D) is a growing health problem worldwide due to increased levels of obesity and can lead to other life-threatening diseases, such as cardiovascular and kidney diseases. As the number of individuals diagnosed with T2D rises, there
Externí odkaz:
https://doaj.org/article/ee675cc39d0249e5bd93f8603236b0df
Autor:
Laura Arribas-Hernández, Sarah Rennie, Tino Köster, Carlotta Porcelli, Martin Lewinski, Dorothee Staiger, Robin Andersson, Peter Brodersen
Publikováno v:
eLife, Vol 10 (2021)
Specific recognition of N6-methyladenosine (m6A) in mRNA by RNA-binding proteins containing a YT521-B homology (YTH) domain is important in eukaryotic gene regulation. The Arabidopsis YTH domain protein ECT2 is thought to bind to mRNA at URU(m6A)Y si
Externí odkaz:
https://doaj.org/article/c4c5250bada5435a997e38dc94e14e1e
Autor:
Laura Arribas-Hernández, Sarah Rennie, Michael Schon, Carlotta Porcelli, Balaji Enugutti, Robin Andersson, Michael D Nodine, Peter Brodersen
Publikováno v:
eLife, Vol 10 (2021)
Gene regulation via N6-methyladenosine (m6A) in mRNA involves RNA-binding proteins that recognize m6A via a YT521-B homology (YTH) domain. The plant YTH domain proteins ECT2 and ECT3 act genetically redundantly in stimulating cell proliferation durin
Externí odkaz:
https://doaj.org/article/b9847e04c0e8441cae1b125dcde7e00e
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Transcriptional regulation is coupled with chromosomal positioning and chromatin architecture. Here the authors develop a transcriptional decomposition approach to separate expression associated with genome structure from independent effects not dire
Externí odkaz:
https://doaj.org/article/8fba3c63d1ce45de95bd48d281f5b53b