Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sarah R. Webb"'
Autor:
Jason K.K. Low, Ana P.G. Silva, Mehdi Sharifi Tabar, Mario Torrado, Sarah R. Webb, Benjamin L. Parker, Maryam Sana, Callum Smits, Jason W. Schmidberger, Lou Brillault, Matthew J. Jackman, David C. Williams, Jr., Gerd A. Blobel, Sandra B. Hake, Nicholas E. Shepherd, Michael J. Landsberg, Joel P. Mackay
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108450- (2020)
Summary: The nucleosome remodeling and deacetylase (NuRD) complex is essential for metazoan development but has been refractory to biochemical analysis. We present an integrated analysis of the native mammalian NuRD complex, combining quantitative ma
Externí odkaz:
https://doaj.org/article/67462e4b5dec48dc92db0b2bce9d1594
Autor:
Otto J.P. Kyrieleis, Pauline B. McIntosh, Sarah R. Webb, Lesley J. Calder, Janette Lloyd, Nisha A. Patel, Stephen R. Martin, Carol V. Robinson, Peter B. Rosenthal, Stephen J. Smerdon
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3099-3106 (2016)
BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is recruited to damaged chromatin as a component of the BRCA1-A
Externí odkaz:
https://doaj.org/article/f2309bca943b435cac90ed30c0bcf62c
Autor:
Maryam Sana, Mehdi Sharifi Tabar, Michael J. Landsberg, Jason W. Schmidberger, Callum Smits, Joel P. Mackay, Sarah R. Webb, Benjamin L. Parker, Matthew J Jackman, Ana P. G. Silva, Lou Brillault, Gerd A. Blobel, Nicholas E. Shepherd, Mario Torrado, Jason Low, David C. Williams, Sandra B. Hake
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108450-(2020)
The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for development in complex animals but has been refractory to biochemical analysis. We present the first integrated analysis of the architecture of the native mammalian NuRD comple
Autor:
Hinnerk Saathoff, Benjamin L. Parker, Nicholas E. Shepherd, Mario Torrado, Ana P. G. Silva, Daniel P. Ryan, Mattias Brofelth, Jason Low, Sarah R. Webb, Joel P. Mackay
Publikováno v:
Journal of Biological Chemistry. 291:15853-15866
Chromatin remodeling enzymes act to dynamically regulate gene accessibility. In many cases, these enzymes function as large multicomponent complexes that in general comprise a central ATP-dependent Snf2 family helicase that is decorated with a variab
Autor:
Joel P. Mackay, Daniel P. Ryan, Benjamin L. Parker, Hinnerk Saathoff, Jason Low, Mattias Brofelth, Nicholas E. Shepherd, Ana P. G. Silva, Anne Trinh, Sarah R. Webb
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:960-965
We have developed an approach for directly isolating an intact multi-protein chromatin remodeling complex from mammalian cell extracts using synthetic peptide affinity reagent 4. FOG1(1–15), a short peptide sequence known to target subunits of the
Autor:
Benjamin L. Parker, Nicholas E. Shepherd, Jason W. Schmidberger, Michael J. Landsberg, Antoine M. van Oijen, Mario Torrado, Medhi Sharifitabar, Jason Low, Sarah R. Webb, Hinnerk Saathoff, Joel P. Mackay, Bishnu P. Paudel, Ana P. G. Silva
Publikováno v:
The FASEB Journal. 31
Autor:
Pauline B. McIntosh, Stephen R. Martin, Sarah R. Webb, O.J.P. Kyrieleis, Carol V. Robinson, Peter B. Rosenthal, Lesley J. Calder, Janette Lloyd, Stephen J. Smerdon, Nisha A. Patel
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3099-3106 (2016)
Cell Reports
Cell Reports
Summary BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is recruited to damaged chromatin as a component of the
Autor:
Gerd A. Blobel, Roland Gamsjaeger, Janine M. Lamonica, Joel P. Mackay, Sarah R. Webb, Andrew N. Billin
Publikováno v:
Molecular and Cellular Biology. 31:2632-2640
Recent data demonstrate that small synthetic compounds specifically targeting bromodomain proteins can modulate the expression of cancer-related or inflammatory genes. Although these studies have focused on the ability of bromodomains to recognize ac