Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sarah R. Jacobs"'
Autor:
Kurtis M. Host, Sarah R. Jacobs, John A. West, Zhigang Zhang, Lindsey M. Costantini, Charles M. Stopford, Dirk P. Dittmer, Blossom Damania
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with the human malignancy Kaposi’s sarcoma and the lymphoproliferative disorders primary effusion lymphoma and multicentric Castleman’s disease. KSHV establishes lytic infect
Externí odkaz:
https://doaj.org/article/1500b2e7ba7f4ffa9862cea2aac65852
Autor:
Blossom eDamania, Sarah R Jacobs
Publikováno v:
Frontiers in Immunology, Vol 2 (2011)
Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) is a large double stranded DNA gammaherpesvirus, and the etiological agent for three human malignancies: Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castlemen’s disease. To establ
Externí odkaz:
https://doaj.org/article/e30614b79d4142169e178df9e17ca8ab
Publikováno v:
PLoS Biology, Vol 4, Iss 8, p e235 (2006)
Switching by parasites to novel hosts has profound effects on ecological and evolutionary disease dynamics. Switching requires that parasites are able to establish contact with novel hosts and to overcome host defenses. For most host-parasite associa
Externí odkaz:
https://doaj.org/article/c638a1a86d1d45c4952010eeed384851
Autor:
Blossom Damania, Amy C. Wollish, Mark T. Heise, Sarah R. Jacobs, David J. Blackbourn, Sean M. Gregory, Christopher L. Bennett, John A. West
Publikováno v:
Journal of Virology. 87:798-806
Kaposi's sarcoma-associated herpesvirus (KSHV) infection is correlated with three human malignancies and can establish lifelong latent infection in multiple cell types within its human host. In order to establish and maintain infection, KSHV utilizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa92eff82d4f16b90424e4ecfaf39324
https://doi.org/10.1128/jvi.01851-12
https://doi.org/10.1128/jvi.01851-12
Autor:
Sarah R. Jacobs, Sarah A. Sullivan, Valerie A. Gerriets, Emily F. Mason, Andrew N. Macintyre, Nancie J. MacIver, Ryan D. Michalek, Jeffrey C. Rathmell, Amanda G. Nichols
Publikováno v:
The Journal of Immunology. 186:3299-3303
Stimulated CD4+ T lymphocytes can differentiate into effector T cell (Teff) or inducible regulatory T cell (Treg) subsets with specific immunological roles. We show that Teff and Treg require distinct metabolic programs to support these functions. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ae7fd62a8285508c0e947e86ff3f8f
https://doi.org/10.4049/jimmunol.1003613
https://doi.org/10.4049/jimmunol.1003613
Autor:
Jessica A. Wofford, Gerard P. Zambetti, Olga Ilkayeva, Tingyu Liu, Sarah R. Jacobs, Jeffrey C. Rathmell, Valerie A. Gerriets, Sean P. Garrison, Yuxing Zhao, Amanda N. Nichols, Jonathan L. Coloff, Brian J. Altman, Emily F. Mason
Publikováno v:
Journal of Biological Chemistry. 286:5921-5933
The PI3K/Akt pathway is activated in stimulated cells and in many cancers to promote glucose metabolism and prevent cell death. Although inhibition of Akt-mediated cell survival may provide a means to eliminate cancer cells, this survival pathway rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92516e1b733a0adfb83aa89d5d23a2be
https://doi.org/10.1074/jbc.m110.179101
https://doi.org/10.1074/jbc.m110.179101
Autor:
Emily F. Mason, Ryan D. Michalek, Jeffrey C. Rathmell, Brian J. Altman, Andrew N. Macintyre, Sarah R. Jacobs, You-Wen He, Olga Ilkayeva, Wei Jia, Jonathon L. Coloff
Publikováno v:
Oncogene
Hematopoietic cells normally require cell extrinsic signals to maintain metabolism and survival. In contrast, cancer cells can express constitutively active oncogenic kinases such as BCR-Abl that promote these processes independent of extrinsic growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39573c52fa1ed697bff7d165eb96aba
https://doi.org/10.1038/onc.2010.561
https://doi.org/10.1038/onc.2010.561
Publikováno v:
The Journal of Immunology. 184:3461-3469
It has become apparent that T cells require growth signals to maintain function and viability necessary to maintain proper immune homeostasis. One means by which cell extrinsic signals may mediate these effects is by sustaining sufficient basal cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b04d6c6e8705046fefc70cd09764f37
https://doi.org/10.4049/jimmunol.0902593
https://doi.org/10.4049/jimmunol.0902593
Autor:
Emily C. Ferguson, Jeffrey C. Rathmell, Kai Cui, Sarah R. Jacobs, Yuxing Zhao, Jonathan L. Coloff
Publikováno v:
Journal of Biological Chemistry. 283:36344-36353
Growth factor stimulation and oncogenic transformation lead to increased glucose metabolism that may provide resistance to cell death. We have previously demonstrated that elevated glucose metabolism characteristic of stimulated or cancerous cells ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f88bb21df4578ed496e154e5afb92e2
https://doi.org/10.1074/jbc.m803580200
https://doi.org/10.1074/jbc.m803580200
Autor:
Nancie J. MacIver, Jessica A. Wofford, Jonathan L. Coloff, Jeffrey C. Rathmell, Sarah R. Jacobs, Heather L. Wieman
Publikováno v:
Journal of Leukocyte Biology. 84:949-957
Lymphocytes require glucose uptake and metabolism for normal survival and function. The signals that regulate the expression and localization of glucose transporter 1 (Glut1) to allow glucose uptake in T cells are now beginning to be understood. Rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f0d2742f472749680164fbf6a55f2a
https://doi.org/10.1189/jlb.0108024
https://doi.org/10.1189/jlb.0108024