Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sarah R. Dunn"'
Autor:
null Karina C. Lockwood, null Travis B. Lear, null Shristi Rajbhandari, null Alison C. McKelvey, null Sarah R. Dunn, null Áine N. Boudreau, null Yuan Liu, null Bill B. Chen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::429e375f460d226b22728ec6c56f47ba
https://doi.org/10.1111/febs.16780/v2/response1
https://doi.org/10.1111/febs.16780/v2/response1
Autor:
Alison C McKelvey, Travis B Lear, Sarah R Dunn, John Evankovich, James D Londino, Joseph S Bednash, Yingze Zhang, Bryan J McVerry, Yuan Liu, Bill B Chen
Publikováno v:
eLife, Vol 5 (2016)
Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe a novel mechanism regulating TLR2 protein expression and subsequent cytokine release throug
Externí odkaz:
https://doaj.org/article/08233b1545cd43788cdf9e3ac9d8943a
Autor:
Manish Verma, Nicholas W. Bateman, P. Anthony Otero, Nathaniel M. Weathington, Christine C. Wu, Erin Steer, Sarah R. Dunn, Rama K. Mallampalli, Charleen T. Chu, Bill B. Chen, Travis Lear, Alison C. McKelvey, Mauricio Rojas, Yuan Liu, Yu Jiang, Kent Z.Q. Wang
Publikováno v:
JCI Insight
Mitochondrial quality control is mediated by the PTEN-induced kinase 1 (PINK1), a cytoprotective protein that is dysregulated in inflammatory lung injury and neurodegenerative diseases. Here, we show that a ubiquitin E3 ligase receptor component, FBX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c41065d9222d07bf56725319d2e75d
https://doi.org/10.1172/jci.insight.131834
https://doi.org/10.1172/jci.insight.131834
Autor:
James D. Londino, Bill B. Chen, Rama K. Mallampalli, Travis Lear, Sarah R. Dunn, John Evankovich, Yuan Liu, Alison C. McKelvey
Publikováno v:
The FASEB Journal. 31:3894-3903
The receptor for advanced glycation end products (RAGE) is a highly expressed cell membrane receptor serving to anchor lung epithelia to matrix components, and it also amplifies inflammatory signaling during acute lung injury. However, mechanisms tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f12030da0301c985be15a3a8b35ae94
https://doi.org/10.1096/fj.201700031r
https://doi.org/10.1096/fj.201700031r
Autor:
James D. Londino, Travis Lear, Rachael A. Gordon, Karina C. Lockwood, Robert Lafyatis, Shristi Rajbhandari, Michael J. Jurczak, John Evankovich, Christine L. Burton, Tiffany A. Coon, Bill B. Chen, Alison C. McKelvey, Yingze Zhang, Mark J. Shlomchik, Eleanor Valenzi, Sarah R. Dunn, Yuan Liu, Bryan J. McVerry, Sebastien Gingras
Publikováno v:
JCI Insight. 4
Dysregulated proinflammatory cytokine release has been implicated in the pathogenesis of several life-threatening acute lung illnesses such as pneumonia, sepsis, and acute respiratory distress syndrome. Suppressors of cytokine signaling proteins, par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99b514839024e80fa822df1149a72ec
https://doi.org/10.1172/jci.insight.129110
https://doi.org/10.1172/jci.insight.129110
Autor:
Sarah R. Dunn, Aazrin Mir, John Evankovich, Yuan Liu, Bill B. Chen, Travis Lear, Alison C. McKelvey
As an α-chemokine receptor specific for stromal-derived-factor-1 (SDF-1, also called CXCL12), C-X-C chemokine receptor type 4 (CXCR4) plays a vital role in chemotactically attracting lymphocytes during inflammation. CXCR4 also regulates HIV infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a43559c59c1de5f7273dcdbdf939c2f
Publikováno v:
Journal of Homosexuality. 64:1069-1091
Building on psychological theories of motivation for collective action, we introduce a new individual difference measure of queer consciousness, defined as a politicized collective identity around sexual orientation. The Queer Consciousness Scale (QC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc14c0d17200804c0a820bf3a70de79
https://doi.org/10.1080/00918369.2016.1236599
https://doi.org/10.1080/00918369.2016.1236599
Autor:
Travis Lear, Yingze Zhang, Tiffany A. Coon, Yuan Liu, Bill B. Chen, William Connelly, Shristi Rajbhandari, Alison C. McKelvey, Sarah R. Dunn, Joe Y. Zhao, Daniel J. Kass
Publikováno v:
The Journal of Experimental Medicine
Lear et al. report a novel molecular pathway in which Fibrosis Inducing E3 Ligase 1 (FIEL1) regulates TGFβ and fibrosis pathway through SUMO-E3 ligase PIAS4. They also develop a small molecule inhibitor toward FIEL1 that is highly effective in ameli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d53f5b1e39d53cbabb696432adb0378
https://doi.org/10.1084/jem.20151229
https://doi.org/10.1084/jem.20151229
Autor:
Wei Chen, Sheng Xiong, Yutong Zhao, Yan Chen, Jin Li, Chunbin Zou, Sarah R. Dunn, Bill B. Chen, Rama K. Mallampalli
Publikováno v:
Journal of Biological Chemistry. 289:7092-7098
Histone acetyltransferase mortality factor 4-like 1 (MORF4L1) is a relatively new histone acetyltransferase component that exists as a homodimer to exert its epigenetic function. The mechanism of MORF4L1 self-assembly is unknown. Here we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced072b29a2b42f1477624d591c155c9
https://doi.org/10.1074/jbc.m113.527507
https://doi.org/10.1074/jbc.m113.527507
Autor:
Sarah R. Dunn, Chunbin Zou, Jennifer R. Glasser, Claire Wang, Nathaniel M. Weathington, Yutong Zhao, Rama K. Mallampalli, Tiffany A. Coon, Bill B. Chen, Jing Zhao
Publikováno v:
The Journal of Immunology. 191:5247-5255
Cytokine-driven inflammation underlies the pathobiology of a wide array of infectious and immune-related disorders. The TNFR-associated factor (TRAF) proteins have a vital role in innate immunity by conveying signals from cell surface receptors to el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cccdd7d48baefc1880430fb9b10b4e9
https://doi.org/10.4049/jimmunol.1300456
https://doi.org/10.4049/jimmunol.1300456