Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sarah R Klein"'
Autor:
Sarah R Klein, Hong Jiang, Mohammad B Hossain, Xuejun Fan, Joy Gumin, Andrew Dong, Marta M Alonso, Candelaria Gomez-Manzano, Juan Fueyo
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153814 (2016)
Adenoviruses are highly immunogenic and are being examined as potential vectors for immunotherapy. Infection by oncolytic adenovirus is followed by massive autophagy in cancer cells. Here, we hypothesize that autophagy regulates the processing of ade
Externí odkaz:
https://doaj.org/article/49e85eada63540aea48f4896c19713de
Autor:
Sujan Piya, Erin J White, Sarah R Klein, Hong Jiang, Timothy J McDonnell, Candelaria Gomez-Manzano, Juan Fueyo
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29467 (2011)
The mechanisms underlying adenovirus-mediated autophagy are currently unknown. Recently, members of the Bcl-2 protein family have been associated with autophagy. It was also reported that the Bcl-2 homology-3 (BH3) domain encompassed by both Beclin 1
Externí odkaz:
https://doaj.org/article/d39b8b86cb3c41e0b35283011132b78d
Autor:
Gordon J. Freeman, Glenn Dranoff, Arlene H. Sharpe, Nancy E. Kohl, Lei Qin, F. Stephen Hodi, Annick D. Van Den Abbeele, Patrick Y. Wen, Jun Zhou, Xiaoyun Liao, Amy Saur Conway, Kristen L. Jones, Shakti H. Ramkissoon, Scott J. Rodig, Keith L. Ligon, Sarah R. Klein, Prafulla C. Gokhale, David A. Reardon
Inhibition of immune checkpoints, including cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), and its ligand PD-L1, has demonstrated exciting and durable remissions across a spectrum of malignancies. Combinatorial regimens blockin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::426f4fd379327be3e120152d731923d8
https://doi.org/10.1158/2326-6066.c.6548479.v1
https://doi.org/10.1158/2326-6066.c.6548479.v1
Autor:
Gordon J. Freeman, Glenn Dranoff, Arlene H. Sharpe, Nancy E. Kohl, Lei Qin, F. Stephen Hodi, Annick D. Van Den Abbeele, Patrick Y. Wen, Jun Zhou, Xiaoyun Liao, Amy Saur Conway, Kristen L. Jones, Shakti H. Ramkissoon, Scott J. Rodig, Keith L. Ligon, Sarah R. Klein, Prafulla C. Gokhale, David A. Reardon
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dac49ab2d8a7f46826fb2d25eb2b32
https://doi.org/10.1158/2326-6066.22537567
https://doi.org/10.1158/2326-6066.22537567
Autor:
Gordon J. Freeman, Glenn Dranoff, Arlene H. Sharpe, Nancy E. Kohl, Lei Qin, F. Stephen Hodi, Annick D. Van Den Abbeele, Patrick Y. Wen, Jun Zhou, Xiaoyun Liao, Amy Saur Conway, Kristen L. Jones, Shakti H. Ramkissoon, Scott J. Rodig, Keith L. Ligon, Sarah R. Klein, Prafulla C. Gokhale, David A. Reardon
Supplemental Figure 1. Bioluminescence plots of individual animals following treatment with immune checkpoint blocking mAbs. Supplemental Figure 2. Immune cell infiltrates within intracranial GL261-luc2 tumor following treatment with isotype control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd7d6bd4da2c39cf567d1906563af73
https://doi.org/10.1158/2326-6066.22537570
https://doi.org/10.1158/2326-6066.22537570
Autor:
Gordon J. Freeman, Glenn Dranoff, Arlene H. Sharpe, Nancy E. Kohl, Lei Qin, F. Stephen Hodi, Annick D. Van Den Abbeele, Patrick Y. Wen, Jun Zhou, Xiaoyun Liao, Amy Saur Conway, Kristen L. Jones, Shakti H. Ramkissoon, Scott J. Rodig, Keith L. Ligon, Sarah R. Klein, Prafulla C. Gokhale, David A. Reardon
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc8099d9749659cb914065fe91d8fdf
https://doi.org/10.1158/2326-6066.22537573.v1
https://doi.org/10.1158/2326-6066.22537573.v1
Autor:
Emily B. Shacter, Yves Pommier, Noritaka Adachi, Eriko Toyoda, Keli K. Agama, Sarah R. Klein, V. Ashutosh Rao
Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone (Dp44mT) is being developed as an iron chelator with selective anticancer activity. We investigated the mechanism whereby Dp44mT kills breast cancer cells, both as a single agent and in combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d67f7e5b25550430b1673a4e48a7c2e2
https://doi.org/10.1158/0008-5472.c.6499497.v1
https://doi.org/10.1158/0008-5472.c.6499497.v1
Autor:
Emily B. Shacter, Yves Pommier, Noritaka Adachi, Eriko Toyoda, Keli K. Agama, Sarah R. Klein, V. Ashutosh Rao
Supplementary Figure 1 from The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase IIα in Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bb9a544c258d7ea3373a973f14c7ff
https://doi.org/10.1158/0008-5472.22380231.v1
https://doi.org/10.1158/0008-5472.22380231.v1
Autor:
Emily B. Shacter, Yves Pommier, Noritaka Adachi, Eriko Toyoda, Keli K. Agama, Sarah R. Klein, V. Ashutosh Rao
Supplementary Figure Legend and Methods from The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase IIα in Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0459f5a906982fe137c1bd04657d42fc
https://doi.org/10.1158/0008-5472.22380228.v1
https://doi.org/10.1158/0008-5472.22380228.v1
Autor:
Kathleen M. Mahoney, Seth Maleri, Gordon J. Freeman, Vikram R. Juneja, Xia Bu, Carol Reynolds, Kathleen A. McGuire, Philippe Armand, Jerome Ritz, Sarah R. Klein, Edward A. Greenfield, Ping Hua, Baogong Zhu, Melissa T. Bu, Arlene H. Sharpe
Publikováno v:
Cancer Immunol Res
PD-1 expression marks activated T cells susceptible to PD-1–mediated inhibition but not whether a PD-1–mediated signal is being delivered. Molecular predictors of response to PD-1 immune checkpoint blockade (ICB) are needed. We describe a monoclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ce7fd91c667eba6f995c8eb5b61370
https://doi.org/10.1158/2326-6066.cir-21-0493
https://doi.org/10.1158/2326-6066.cir-21-0493