Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sarah Quynh Giao To"'
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 145:179-186
Aromatase is the critical enzyme that converts androgens to estrogens. It is frequently highly expressed in the tumour bearing breast of women diagnosed with estrogen receptor positive tumours, resulting in dramatically increased local estrogen produ
Autor:
To, Sarah Quynh Giao
Approximately one in nine women in Australia are diagnosed with breast cancer throughout their lifetime. Major risk factors, including increased age and adiposity, coincide with prolonged exposure to circulating oestrogens in the body. As a consequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf8429b41ff2eb53687935f268d79d7
Publikováno v:
Molecular and Cellular Endocrinology. 394:21-28
The cytokine Tumor Necrosis Factor-α is critical to Estrogen Receptor positive breast cancer pathology, stimulating estrogen-biosynthesis pathways and preventing the differentiation of estrogen-producing fibroblasts. High concentrations of TNFα are
Publikováno v:
Endocrine-Related Cancer. 21:T33-T55
The heritable component of breast cancer accounts for only a small proportion of total incidences. Environmental and lifestyle factors are therefore considered to among the major influencing components increasing breast cancer risk. Endocrine-disrupt
Autor:
Ian D. Davis, Arun Azad, Maria Docanto, Lisa G. Horvath, Andrew Mant, Carmel Pezaro, Kate L. Mahon, Sarah Quynh Giao To, Nicole Ng, Eva Segelov, Lisa Jane K. Graham, Heidi Fettke, Phillip Parente, Edmond M. Kwan, Patricia Bukczynska, David Pook
Publikováno v:
Journal of Clinical Oncology. 37:188-188
188 Background: Identifying predictive biomarkers for mCRPC patients receiving androgen receptor signalling inhibitors (ARSI) or chemotherapy remains an unmet clinical need. FOLH1 encodes for Prostate-Specific Membrane Antigen (PSMA), a type II glyco
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 137:157-164
Epigenome changes have been widely demonstrated to contribute to the initiation and progression of a vast array of cancers including breast cancer. The reversible process of many epigenetic modifications is thus an attractive feature for the developm
Autor:
Ashwini L. Chand, Zhe Zhao, Sarah Quynh Giao To, Colin Clyne, Kyren A. Lazarus, Kevin Christopher Knower
Publikováno v:
Biochemical and Biophysical Research Communications. 438:533-539
The expression of orphan nuclear receptor Liver Receptor Homolog-1 (LRH-1) is elevated in breast cancer and promotes proliferation, migration and invasion in vitro. LRH-1 expression is regulated by oestrogen (E2), with LRH-1 mRNA transcript levels hi
Autor:
Kerrie A. Herridge, Kevin Christopher Knower, Michelle Van Sinderen, Jane Honeyman, Colin Clyne, Wah Chin Boon, Jenny D. Y. Chow, Sebastian Beck Jørgensen, Margaret E. E. Jones, Sarah Quynh Giao To, Evan R. Simpson, Gregory R. Steinberg
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87230 (2014)
PLoS ONE
PLoS ONE
Estrogens are known to play a role in modulating metabolic processes within the body. The Aromatase knockout (ArKO) mice have been shown to harbor factors of Metabolic syndrome with central adiposity, hyperinsulinemia and male-specific hepatic steato
Autor:
Kevin Christopher Knower, Sarah Quynh Giao To, Ashwini L. Chand, Nde Cb Magne, Colin Clyne, Zhe Zhao, Kyren A. Lazarus
Publikováno v:
Atlas of Genetics and Cytogenetics in Oncology and Haematology.
Review on GREB1 (growth regulation by estrogen in breast cancer 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Publikováno v:
Biochemical and biophysical research communications. 433(1)
The Early Growth Response genes EGR2 and EGR3 play an important role in mediating TNFα induced aromatase expression via the adipose specific promoter PI.4. The upstream signalling pathway stimulated by TNFα to initiate this is unknown. The aim of t