Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Sarah Preston"'
Autor:
Michael Stear, Sarah Preston, David Piedrafita, George Cullimore, Katarzyna Donskow-Łysoniewska
Publikováno v:
Parasitologia, Vol 4, Iss 2, Pp 137-149 (2024)
The control of parasitic nematode infection in sheep and other animals is threatened by the evolution of drug resistance in parasite populations. One recommendation to delay the onset of drug resistance is to estimate the flock mean faecal egg counts
Externí odkaz:
https://doaj.org/article/627353ff305c42049b7d0496dc3eb1b6
Autor:
Sarah Preston-Alp, Lisa Beatrice Caruso, Chenhe Su, Kelsey Keith, Samantha S. Soldan, Davide Maestri, Jozef Madzo, Andrew Kossenkov, Giorgia Napoletani, Benjamin Gewurz, Paul M. Lieberman, Italo Tempera
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Epstein-Barr virus (EBV) is associated with 10% of human gastric carcinomas, which are distinguished by a CpG island methylator phenotype. In gastric carcinoma tumors and cell lines, the EBV genome also exhibits a high degree of 5-methyl cyt
Externí odkaz:
https://doaj.org/article/6a1e68a25f2743b5ba8846d77af44340
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2283 (2023)
Nematode infection is a major threat to the health of humans, domestic animals and wildlife. Nematodes vary in their effect on the host and in the mechanisms underlying immunity but the general features are becoming clear. There is considerable varia
Externí odkaz:
https://doaj.org/article/3484eefddb2445bc81c45261b9bed179
Autor:
Andreas Hofmann, Sarah Preston, Megan Cross, H. M. P. Dilrukshi Herath, Anne Simon, Robin B. Gasser
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-6 (2019)
Abstract Background Analyses of replicates in sets of discrete data, typically acquired in multi-well plate formats, is a recurring task in many contemporary areas in the Life Sciences. The availability of accessible cross-platform data analysis tool
Externí odkaz:
https://doaj.org/article/7e27f05c91ca449c822f2ee2e984223f
Autor:
Yaqing Jiao, Sarah Preston, Jose F. Garcia-Bustos, Jonathan B. Baell, Sabatino Ventura, Thuy Le, Nicole McNamara, Nghi Nguyen, Antony Botteon, Cameron Skinner, Jill Danne, Sarah Ellis, Anson V. Koehler, Tao Wang, Bill C.H. Chang, Andreas Hofmann, Abdul Jabbar, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss , Pp 59-71 (2019)
In the present study, the anthelmintic activity of a human tyrosine kinase inhibitor, AG-1295, and 14 related tetrahydroquinoxaline analogues against Haemonchus contortus was explored. These compounds were screened against parasitic larvae - exsheath
Externí odkaz:
https://doaj.org/article/caac004597e54aa1a78f4bf273595773
Autor:
Linh Thuy Nguyen, Thomas Kurz, Sarah Preston, Hjoerdis Brueckmann, Beate Lungerich, H. M. P. Dilrukshi Herath, Anson V. Koehler, Tao Wang, Lenka Skálová, Abdul Jabbar, Robin B. Gasser
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-9 (2019)
Abstract Background Due to anthelmintic resistance problems, there is a need to discover and develop new drugs for the treatment and control of economically important and pathogenic nematodes of livestock animals. With this focus in mind, we screened
Externí odkaz:
https://doaj.org/article/667512ea98824374a6e5446300f762b8
Autor:
H.M.P. Dilrukshi Herath, Sarah Preston, Abdul Jabbar, Jose Garcia-Bustos, Russell S. Addison, Sasha Hayes, Topul Rali, Tao Wang, Anson V. Koehler, Bill C.H. Chang, Andreas Hofmann, Rohan A. Davis, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss , Pp 72-79 (2019)
Due to the widespread occurrence and spread of anthelmintic resistance, there is a need to develop new drugs against resistant parasitic nematodes of livestock animals. The Nobel Prize-winning discovery and development of the anti-parasitic drugs ave
Externí odkaz:
https://doaj.org/article/db002d2db68d42d898bbee95ef530872
Autor:
H.M.P. Dilrukshi Herath, Hongjian Song, Sarah Preston, Abdul Jabbar, Tao Wang, Sean L. McGee, Andreas Hofmann, Jose Garcia-Bustos, Bill C.H. Chang, Anson V. Koehler, Yuxiu Liu, Qiaoqiao Ma, Pengxiang Zhang, Qiqi Zhao, Qingmin Wang, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 379-385 (2018)
Due to widespread drug resistance in parasitic nematodes, there is a need to develop new anthelmintics. Given the cost and time involved in developing a new drug, the repurposing of known chemicals can be a promising, alternative approach. In this co
Externí odkaz:
https://doaj.org/article/7f85d261e2e04397b5b0c85cb1628608
Autor:
Sarah Preston, Yaqing Jiao, Jonathan B. Baell, Jennifer Keiser, Simon Crawford, Anson V. Koehler, Tao Wang, Moana M. Simpson, Ray M. Kaplan, Karla J. Cowley, Kaylene J. Simpson, Andreas Hofmann, Abdul Jabbar, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 3, Pp 286-294 (2017)
The discovery and development of novel anthelmintic classes is essential to sustain the control of socioeconomically important parasitic worms of humans and animals. With the aim of offering novel, lead-like scaffolds for drug discovery, Compounds Au
Externí odkaz:
https://doaj.org/article/8ba8ab2468e24449941e1de9e44ab2d5
Autor:
Yaqing Jiao, Sarah Preston, Anson V. Koehler, Andreas J. Stroehlein, Bill C. H. Chang, Kaylene J. Simpson, Karla J. Cowley, Michael J. Palmer, Benoît Laleu, Timothy N. C. Wells, Abdul Jabbar, Robin B. Gasser
Publikováno v:
Parasites & Vectors, Vol 10, Iss 1, Pp 1-7 (2017)
Abstract Background In partnership with the Medicines for Malaria Venture (MMV), we screened a collection (‘Stasis Box’) of 400 compounds (which have been in clinical development but have not been approved for illnesses other than neglected infec
Externí odkaz:
https://doaj.org/article/42151eb5042e4f648e96208755c17b05