Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sarah Piel"'
Autor:
Sarah Piel, Meagan J. McManus, Kristina N. Heye, Forrest Beaulieu, Hossein Fazelinia, Joanna I. Janowska, Bryce MacTurk, Jonathan Starr, Hunter Gaudio, Nisha Patel, Marco M. Hefti, Martin E. Smalley, Jordan N. Hook, Neha V. Kohli, James Bruton, Thomas Hallowell, Nile Delso, Anna Roberts, Yuxi Lin, Johannes K. Ehinger, Michael Karlsson, Robert A. Berg, Ryan W. Morgan, Todd J. Kilbaugh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Neurological and cardiac injuries are significant contributors to morbidity and mortality following pediatric in-hospital cardiac arrest (IHCA). Preservation of mitochondrial function may be critical for reducing these injuries. Dimethyl fum
Externí odkaz:
https://doaj.org/article/e97966aa91bd40e285a7c98d147519b0
Autor:
Kumaran Senthil, Abhay Ranganathan, Sarah Piel, Marco M. Hefti, Ron W. Reeder, Matthew P. Kirschen, Jonathan Starr, Sarah Morton, Hunter A. Gaudio, Julia C. Slovis, Jeremy R. Herrmann, Robert A. Berg, Todd J. Kilbaugh, Ryan W. Morgan
Publikováno v:
Resuscitation Plus, Vol 19, Iss , Pp 100726- (2024)
Introduction: Swine exhibit cerebral cortex mitochondrial dysfunction and neuropathologic injury after hypoxic cardiac arrest treated with hemodynamic-directed CPR (HD-CPR) despite normal Cerebral Performance Category scores. We analyzed the temporal
Externí odkaz:
https://doaj.org/article/94a4678169044e63ac5a08f6f6c382e0
Autor:
Sarah Piel, Joanna I. Janowska, J. Laurenson Ward, Meagan J. McManus, Joshua S. Jose, Jonathan Starr, Malkah Sheldon, Carly L. Clayman, Eskil Elmér, Magnus J. Hansson, David H. Jang, Michael Karlsson, Johannes K. Ehinger, Todd J. Kilbaugh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Pesticides account for hundreds of millions of cases of acute poisoning worldwide each year, with organophosphates (OPs) being responsible for the majority of all pesticide-related deaths. OPs inhibit the enzyme acetylcholinesterase (AChE),
Externí odkaz:
https://doaj.org/article/3a5223e4d0324f0a8e19cb273dbd5e2b
Autor:
Julia C. Slovis, Lindsay Volk, Constantine Mavroudis, Marco Hefti, William P. Landis, Anna L. Roberts, Nile Delso, Thomas Hallowell, Kathryn Graham, Jonathan Starr, Yuxi Lin, Richard Melchior, Vinay Nadkarni, Robert M. Sutton, Robert A. Berg, Sarah Piel, Ryan W. Morgan, Todd J. Kilbaugh
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 4 (2023)
Background The primary objective was to develop a porcine model of prolonged (30 or 60 minutes) pediatric cardiopulmonary resuscitation (CPR) followed by 22‐ to 24‐hour survival with extracorporeal life support, and secondarily to evaluate differ
Externí odkaz:
https://doaj.org/article/04c0e4ecb5de4e31910eedeaa873fbdc
Autor:
Shawn Owiredu, Abhay Ranganathan, John C. Greenwood, Sarah Piel, Joanna I. Janowska, David M. Eckmann, Matthew Kelly, Johannes K. Ehinger, Todd J. Kilbaugh, David H. Jang
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 1263-1271 (2020)
The objective of this study was to compare the use of hydroxocobalamin (B12a) and a succinate prodrug to evaluate for improvement in mitochondrial function in an in vitro model of cyanide poisoning. Peripheral blood mononuclear cells (PBMC) and human
Externí odkaz:
https://doaj.org/article/eba40d26547e4d3e8a47ba8258c4d54c
Autor:
Sarah Piel, Imen Chamkha, Adam Kozak Dehlin, Johannes K Ehinger, Fredrik Sjövall, Eskil Elmér, Magnus J Hansson
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231173 (2020)
Acetaminophen is one of the most common over-the-counter pain medications used worldwide and is considered safe at therapeutic dose. However, intentional and unintentional overdose accounts for up to 70% of acute liver failure cases in the western wo
Externí odkaz:
https://doaj.org/article/38c8ab6c0c2b4962a46ddb921cd97c16
Autor:
Sarah Piel, Johannes K. Ehinger, Imen Chamkha, Eleonor Åsander Frostner, Fredrik Sjövall, Eskil Elmér, Magnus J. Hansson
Publikováno v:
Intensive Care Medicine Experimental, Vol 6, Iss 1, Pp 1-12 (2018)
Abstract Background Metformin is the most common pharmacological treatment for type 2 diabetes. It is considered safe but has been associated with the development of lactic acidosis under circumstances where plasma concentrations exceed therapeutic l
Externí odkaz:
https://doaj.org/article/b766a7ad98dc49df8d06ab85f7ef9daa
Autor:
Johannes K. Ehinger, Sarah Piel, Rhonan Ford, Michael Karlsson, Fredrik Sjövall, Eleonor Åsander Frostner, Saori Morota, Robert W. Taylor, Doug M. Turnbull, Clive Cornell, Steven J. Moss, Carsten Metzsch, Magnus J. Hansson, Hans Fliri, Eskil Elmér
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Mitochondrial complex I deficiency is the most common respiratory chain defect in mitochondrial disease in children and currently there is no effective treatment. In this study, the authors show that succinate prodrugs can alleviate metabolic decompe
Externí odkaz:
https://doaj.org/article/065e786aabe24902981472f3415f76d9
Autor:
Andrew C McCourt, Lovisa Jakobsson, Sara Larsson, Cecilia Holm, Sarah Piel, Eskil Elmér, Maria Björkqvist
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0159870 (2016)
Huntington's disease (HD) is a fatal, autosomal dominantly inherited neurodegenerative disorder, characterised not only by progressive cognitive, motor and psychiatric impairments, but also of peripheral pathology. In both human HD and in mouse model
Externí odkaz:
https://doaj.org/article/71757093ac3f47a7a2b0461599cfce01
Autor:
Oladunni Alomaja, Frances S. Shofer, John C. Greenwood, Sarah Piel, Carly Clayman, Clementina Mesaros, Shih-Han Kao, Samuel S. Shin, Johannes K. Ehinger, Todd J. Kilbaugh, David H. Jang
Publikováno v:
Journal of Medical Toxicology. 19:196-204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b36ca69c939d5d4e60a3d2a4c8781cf
https://doi.org/10.1007/s13181-022-00928-w
https://doi.org/10.1007/s13181-022-00928-w