Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Sarah Owen"'
Autor:
Emma Purcell, Zeqi Niu, Sarah Owen, Madeline Grzesik, Abigail Radomski, Anna Kaehr, Nna-Emeka Onukwugha, Heather Fairbairn Winkler, Nithya Ramnath, Theodore Lawrence, Shruti Jolly, Sunitha Nagrath
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113687- (2024)
Summary: Circulating tumor cells (CTCs) are early signs of metastasis and can be used to monitor disease progression well before radiological detection by imaging. Using an ultrasensitive graphene oxide microfluidic chip nanotechnology built with gra
Externí odkaz:
https://doaj.org/article/22edef97cc344077b92f9687d1846b85
Autor:
Emma Purcell, Sarah Owen, Emily Prantzalos, Abigail Radomski, Nayri Carman, Ting-Wen Lo, Mina Zeinali, Chitra Subramanian, Nithya Ramnath, Sunitha Nagrath
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In non-small cell lung cancer (NSCLC), identifying the presence of sensitizing and resistance epidermal growth factor receptor (EGFR) mutations dictates treatment plans. Extracellular vesicles (EVs) are emerging as abundant, stable potential liquid b
Externí odkaz:
https://doaj.org/article/f88f5036fc264c2a81eb9c63bb5ee78c
Autor:
Brittany Rupp, Sarah Owen, Harrison Ball, Kaylee Judith Smith, Valerie Gunchick, Evan T. Keller, Vaibhav Sahai, Sunitha Nagrath
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7852 (2022)
As pancreatic cancer is the third deadliest cancer in the U.S., the ability to study genetic alterations is necessary to provide further insight into potentially targetable regions for cancer treatment. Circulating tumor cells (CTCs) represent an esp
Externí odkaz:
https://doaj.org/article/d36747c4a4474359a5a1b0a2ce51c5d9
Autor:
Yoon‐Tae Kang, Zeqi Niu, Thomas Hadlock, Emma Purcell, Ting‐Wen Lo, Mina Zeinali, Sarah Owen, Venkateshwar G. Keshamouni, Rishindra Reddy, Nithya Ramnath, Sunitha Nagrath
Publikováno v:
Advanced Science, Vol 8, Iss 6, Pp n/a-n/a (2021)
Abstract As the recognition between natural killer (NK) cells and cancer cells does not require antigen presentation, NK cells are being actively studied for use in adoptive cell therapies in the rapidly evolving armamentarium of cancer immunotherapy
Externí odkaz:
https://doaj.org/article/1fe86000dcdb48de8238d16d2b30f982
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 146 (2022)
Pancreatic ductal adenocarcinoma is typically diagnosed at late stages and has one of the lowest five-year survival rates of all malignancies. In this pilot study, we identify signatures related to survival and treatment response found in circulating
Externí odkaz:
https://doaj.org/article/a12f193c081c4b9a962f187e359203df
Autor:
Lianette Rivera-Báez, Ines Lohse, Eric Lin, Shreya Raghavan, Sarah Owen, Ramdane Harouaka, Kirk Herman, Geeta Mehta, Theodore S. Lawrence, Meredith A. Morgan, Kyle C. Cuneo, Sunitha Nagrath
Publikováno v:
Cancers, Vol 12, Iss 4, p 1011 (2020)
Improvement in pancreatic cancer treatment represents an urgent medical goal that has been hampered by the lack of predictive biomarkers. Circulating Tumor Cells (CTCs) may be able to overcome this issue by allowing the monitoring of therapeutic resp
Externí odkaz:
https://doaj.org/article/159027596c7e475e96be0e3c4ac6f396
Autor:
Gavin D Perkins, Frances Griffiths, Anne-Marie Slowther, Robert George, Zoe Fritz, Philip Satherley, Barry Williams, Norman Waugh, Matthew W Cooke, Sue Chambers, Carole Mockford, Karoline Freeman, Amy Grove, Richard Field, Sarah Owen, Ben Clarke, Rachel Court, Claire Hawkes
Publikováno v:
Health Services and Delivery Research, Vol 4, Iss 11 (2016)
Background: Cardiac arrest is the final common step in the dying process. In the right context, resuscitation can reverse the dying process, yet success rates are low. However, cardiopulmonary resuscitation (CPR) is a highly invasive medical treatmen
Externí odkaz:
https://doaj.org/article/653bfc61529441c7aae5659712ec2bee
Autor:
Yoon-Tae Kang, Ji-Young Kim, Emine Sumeyra Turali-Emre, Hee-Jeong Jang, Minjeong Cha, Abha Kumari, Colin Palacios-Rolston, Chitra Subramanian, Emma Purcell, Sarah Owen, Chung-Man Lim, Rishindra Reddy, Shruthi Jolly, Nithya Ramnath, Nicholas A. Kotov, Sunitha Nagrath
Publikováno v:
Cancer Research. 83:994-994
Small extracellular vesicles, often termed as “exosomes” carry informative cargo containing proteins and lipids, reflective of their cellular origin. Thus, they are promising biomarkers for early diagnosis of cancer. However, conventional profili
Autor:
Harrison Ball, Brittany Rupp, Sarah Owen, Kaylee Smith, Valerie Gunchick, Evan T. Keller, Vaibhav Sahai, Sunitha Nagrath
Publikováno v:
Cancer Research. 83:5581-5581
Metastatic pancreatic cancer suffers from an extremely low five-year survival rate of only 3%. While patients with localized disease show marginally better survival rates, 52% of pancreatic cancers are not diagnosed until metastases have already deve
Autor:
Sarah Owen, Janusz Franco-Barraza, Vaibhav Sahai, Theodore S. Lawrence, Sunitha Nagrath, Jiaqi Shi, Edna Cukierman, Anjali Mittal, Mara H. Sherman, Ziwen Zhu, Noah Meurs, Anirban Maitra, Andrew M. Pickering, Olamide Animasahun, Meredith A. Morgan, Abhinav Achreja, Deepak Nagrath, Ting Wen Lo, Valerie Gunchick, Pooja Parikh
Publikováno v:
Nature metabolism
Branched-chain amino acids (BCAAs) supply both carbon and nitrogen in pancreatic cancers, and increased levels of BCAAs have been associated with increased risk of pancreatic ductal adenocarcinomas (PDACs). It remains unclear, however, how stromal ce