Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sarah Naguib"'
Autor:
Sarah Naguib, Jon R. Backstrom, Elisabeth Artis, Purnima Ghose, Amy Stahl, Rachael Hardin, Ameer A. Haider, John Ang, David J. Calkins, Tonia S. Rex
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Glaucoma, the second leading cause of irreversible blindness worldwide, is associated with age and sensitivity to intraocular pressure (IOP). We have shown that elevated IOP causes an early increase in levels of reactive oxygen species (ROS)
Externí odkaz:
https://doaj.org/article/822803ba53aa43a396111c625495ec4e
Autor:
Sarah Naguib, Carlisle R. DeJulius, Jon R. Backstrom, Ameer A. Haider, John M. Ang, Andrew M. Boal, David J. Calkins, Craig L. Duvall, Tonia S. Rex
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 556 (2023)
Erythropoietin (EPO) is neuroprotective in multiple models of neurodegenerative diseases, including glaucoma. EPO-R76E retains the neuroprotective effects of EPO but diminishes the effects on hematocrit. Treatment with EPO-R76E in a glaucoma model in
Externí odkaz:
https://doaj.org/article/f425def142764bd78d4e216706b866ad
Publikováno v:
Redox Biology, Vol 42, Iss , Pp 101883- (2021)
Oxidative stress contributes to degeneration of retinal ganglion cells and their axons in glaucoma, a leading cause of irreversible blindness worldwide, through sensitivity to intraocular pressure (IOP). Here, we investigated early elevations in reac
Externí odkaz:
https://doaj.org/article/f0c61944a99e41a99ed82ef87ae19a2b
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Our goal was to investigate the neuroprotective effects of galantamine in a mouse model of blast-induced indirect traumatic optic neuropathy (bITON). Galantamine is an FDA-approved acetylcholinesterase inhibitor used to treat mild-moderate Alzheimer'
Externí odkaz:
https://doaj.org/article/804a7522fff24b79b726440a94f10209
Autor:
Sarah Naguib, Jon R Backstrom, Elisabeth Artis, Purnima Ghose, Ameer Haider, John Ang, David J Calkins, Tonia Rex
Background: Glaucoma, the second leading cause of irreversible blindness worldwide, is associated with age and sensitivity to intraocular pressure (IOP). We use an inducible mouse model, in which we detect increased levels of reactive oxygen species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::521824ac2515a67b8611a4c0d8ad1607
https://doi.org/10.21203/rs.3.rs-1750335/v1
https://doi.org/10.21203/rs.3.rs-1750335/v1
Autor:
Sarah Naguib, Mukesh K. Gupta, Carlisle DeJulius, Alexandra Bernardo-Colón, Taylor E. Kavanaugh, Jon R. Backstrom, Tonia S. Rex, Craig L. Duvall
Publikováno v:
J Control Release
Wild-type erythropoietin (EPO) is promising for neuroprotection, but its therapeutic use is limited because it causes a systemic rise in hematocrit. We have developed an EPO-R76E derivative that maintains neuroprotective function without effects on h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d655218feb39627cdaeee9d8c46cbc
https://doi.org/10.1016/j.jconrel.2020.10.010
https://doi.org/10.1016/j.jconrel.2020.10.010
Publikováno v:
Redox Biology, Vol 42, Iss, Pp 101883-(2021)
Redox Biology
Redox Biology
Oxidative stress contributes to degeneration of retinal ganglion cells and their axons in glaucoma, a leading cause of irreversible blindness worldwide, through sensitivity to intraocular pressure (IOP). Here, we investigated early elevations in reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765c582cd3a4ab956ecbc9899dfad66f
http://www.sciencedirect.com/science/article/pii/S2213231721000318
http://www.sciencedirect.com/science/article/pii/S2213231721000318
Publikováno v:
Exp Eye Res
It is well established that an intravitreal needle poke or injection of buffer is protective to the retina in models of photoreceptor degeneration due to release of endogenous neurotrophic factors. Here we assess the effect of intravitreal injection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f3252bccb133a1a89bbc5972e107de
https://europepmc.org/articles/PMC8117180/
https://europepmc.org/articles/PMC8117180/