Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sarah N. Sipe"'
Autor:
Sarah N. Sipe, Emily B. Lancaster, Jamie P. Butalewicz, Christian P. Whitman, Jennifer S. Brodbelt
Publikováno v:
Journal of the American Chemical Society. 144:12299-12309
The recent discovery of asymmetric arrangements of trimers in the tautomerase superfamily (TSF) adds structural diversity to this already mechanistically diverse superfamily. Classification of asymmetric trimers has previously been determined using X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f3fbc2de90d369a667247ced47cc86
https://doi.org/10.1021/jacs.2c03564
https://doi.org/10.1021/jacs.2c03564
Publikováno v:
Anal Chem
New developments in analytical technologies and biophysical methods have advanced the characterization of increasingly complex biomolecular assemblies using native mass spectrometry (MS). Ion mobility methods, in particular, have enabled a new dimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2096274f1c4470702c446a4a2f8eae18
https://doi.org/10.1021/acs.analchem.2c01653
https://doi.org/10.1021/acs.analchem.2c01653
Autor:
Kevin Jeanne Dit Fouque, Sarah N. Sipe, Alyssa Garabedian, German Mejia, Linjia Su, Md Lokman Hossen, Prem P. Chapagain, Fenfei Leng, Jennifer S. Brodbelt, Francisco Fernandez-Lima
Publikováno v:
J Am Soc Mass Spectrom
The mammalian high mobility group protein AT-hook 2 (HMGA2) is an intrinsically disordered DNA-binding protein expressed during embryogenesis. In the present work, the conformational and binding dynamics of HMGA2 and HMGA2 in complex with a 22-nt (DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3389070603403b63c2d1910778e53dab
https://doi.org/10.1021/jasms.2c00101
https://doi.org/10.1021/jasms.2c00101
Autor:
Sarah N. Sipe, Kevin Jeanne Dit Fouque, Alyssa Garabedian, Fenfei Leng, Francisco Fernandez-Lima, Jennifer S. Brodbelt
Publikováno v:
J Am Soc Mass Spectrom
Although it is widely accepted that protein function is largely dependent on its structure, intrinsically disordered proteins (IDPs) lack defined structure but are essential in proper cellular processes. Mammalian high mobility group proteins (HMGA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61f27b7852110977f1db169fa3e181a
https://doi.org/10.1021/jasms.2c00083
https://doi.org/10.1021/jasms.2c00083
Autor:
Joshua E Mayfield, Seema Irani, Edwin E Escobar, Zhao Zhang, Nathaniel T Burkholder, Michelle R Robinson, M Rachel Mehaffey, Sarah N Sipe, Wanjie Yang, Nicholas A Prescott, Karan R Kathuria, Zhijie Liu, Jennifer S Brodbelt, Yan Zhang
Publikováno v:
eLife, Vol 8 (2019)
The Positive Transcription Elongation Factor b (P-TEFb) phosphorylates Ser2 residues of the C-terminal domain (CTD) of the largest subunit (RPB1) of RNA polymerase II and is essential for the transition from transcription initiation to elongation in
Externí odkaz:
https://doaj.org/article/53e0122eb0c34ddbb874f06e2b7e518b
Autor:
James D. Sanders, Samuel W. Shields, Edwin E. Escobar, Michael B. Lanzillotti, Jamie P. Butalewicz, Virginia K. James, Molly S. Blevins, Sarah N. Sipe, Jennifer S. Brodbelt
Publikováno v:
Analytical chemistry. 94(10)
The structural diversity of phospholipids plays a critical role in cellular membrane dynamics, energy storage, and cellular signaling. Despite its importance, the extent of this diversity has only recently come into focus, largely owing to advances i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf803951b23b1cd0fd34a370463e623
https://pubmed.ncbi.nlm.nih.gov/35239318
https://pubmed.ncbi.nlm.nih.gov/35239318
Publikováno v:
Anal Chem
Development of chemical chaperones to solubilize membrane protein complexes in aqueous solutions has allowed for gas-phase analysis of their native-like assemblies, including rapid evaluation of stability and interacting partners. Characterization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56cb6fd0d18f46d7b3a03d8c75d61fd
https://doi.org/10.1021/acs.analchem.9b03689
https://doi.org/10.1021/acs.analchem.9b03689
Autor:
Jennifer S. Brodbelt, Sarah N. Sipe
Publikováno v:
Phys Chem Chem Phys
As applications in mass spectrometry continue to expand into the field of structural biology, there have been an increasing number of studies on noncovalent biological assemblies. Ensuring that protein complexes maintain native-like conformations and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02201ff7dff5003b65a23cf47a7206b
https://doi.org/10.1039/c9cp01144g
https://doi.org/10.1039/c9cp01144g
Autor:
Wendy M. Matthews, Sarah N. Sipe, Haoyi Wu, Edwin E. Escobar, Seema Irani, Jennifer S. Brodbelt, Wanjie Yang, Mukeshkumar Venkatramani, Yan Zhang, Nathaniel T. Burkholder
Publikováno v:
ACS Chem Biol
The C-terminal domain (CTD) of the largest subunit in eukaryotic RNA polymerase II has a repetitive heptad sequence of Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 which is responsible for recruiting transcriptional regulatory factors. The seventh heptad resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a16bb3734a9e57557a1278b7d0d592
https://doi.org/10.1021/acschembio.9b00610
https://doi.org/10.1021/acschembio.9b00610
Autor:
Michelle R. Robinson, Edwin E. Escobar, Jennifer S. Brodbelt, M. Rachel Mehaffey, Nathaniel T. Burkholder, Wanjie Yang, Zhao Zhang, Seema Irani, Karan R. Kathuria, Joshua E. Mayfield, Yan Zhang, Nicholas A Prescott, Sarah N. Sipe, Zhijie Liu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b89da89095279049161cdf2bd54afeb2
https://doi.org/10.7554/elife.48725.020
https://doi.org/10.7554/elife.48725.020
