Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sarah N. Lauder"'
Autor:
Martin J. Scurr, George Lippiatt, Lorenzo Capitani, Kirsten Bentley, Sarah N. Lauder, Kathryn Smart, Michelle S. Somerville, Tara Rees, Richard J. Stanton, Awen Gallimore, James P. Hindley, Andrew Godkin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The presence of SARS-CoV-2-specific antibodies alone is not an accurate determinant of immunity. In this work, the authors investigate if whole-blood based measurement of SARS-CoV-2 specific T cell responses could prognosticate the risk of possible S
Externí odkaz:
https://doaj.org/article/d478f34a0e4948beb39a42e0ae302a63
Autor:
Amanda Thomson, Kathryn Smart, Michelle S. Somerville, Sarah N. Lauder, Gautham Appanna, James Horwood, Lawrence Sunder Raj, Brijesh Srivastava, Dharmaraj Durai, Martin J. Scurr, Åsa V. Keita, Awen M. Gallimore, Andrew Godkin
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal integrity has been associated with ulcerative colitis, Crohn’s disease and pote
Externí odkaz:
https://doaj.org/article/865832664a054e5190d402ae3a6a6bd7
Autor:
Alexander Greenshields-Watson, Meriem Attaf, Bruce J. MacLachlan, Thomas Whalley, Cristina Rius, Aaron Wall, Angharad Lloyd, Hywel Hughes, Kathryn E. Strange, Georgina H. Mason, Andrea J. Schauenburg, Sarah L. Hulin-Curtis, James Geary, Yuan Chen, Sarah N. Lauder, Kathryn Smart, Dhanasekaran Vijaykrishna, Miguel L. Grau, Mikhail Shugay, Robert Andrews, Garry Dolton, Pierre J. Rizkallah, Awen M. Gallimore, Andrew K. Sewell, Andrew J. Godkin, David K. Cole
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107885- (2020)
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usi
Externí odkaz:
https://doaj.org/article/ac1881b0cc804226bb104e9cab830657
Autor:
Maceler Aldrovandi, Christine Hinz, Sarah N. Lauder, Helen Podmore, Martin Hornshaw, David A. Slatter, Victoria J. Tyrrell, Stephen R. Clark, Lawrence J. Marnett, Peter W. Collins, Robert C. Murphy, Valerie B. O’Donnell
Publikováno v:
Redox Biology, Vol 11, Iss , Pp 663-672 (2017)
Activated platelets generate an eicosanoid proposed to be 8-hydroxy-9,10-dioxolane A3 (DXA3). Herein, we demonstrate that significant amounts of DXA3 are rapidly attached to phosphatidylethanolamine (PE) forming four esterified eicosanoids, 16:0p, 18
Externí odkaz:
https://doaj.org/article/2e78047174f0463cac7ed4061eb73ce1
Autor:
Sarah N. Lauder, Victoria J Tyrrell, Keith Allen-Redpath, Maceler Aldrovandi, David Gray, Peter Collins, Simon A Jones, Philip R Taylor, Valerie O'Donnell
Publikováno v:
Wellcome Open Research, Vol 2 (2017)
Background. The myeloid enzyme 12/15-lipoxygenase (LOX), which generates bioactive oxidized lipids, has been implicated in numerous inflammatory diseases, with several studies demonstrating an improvement in pathology in mice lacking the enzyme. Howe
Externí odkaz:
https://doaj.org/article/f5090539914842ae958ac2f738de381f
Autor:
Stefan Milutinovic, Jun Abe, Emma Jones, Inken Kelch, Kathryn Smart, Sarah N. Lauder, Michelle Somerville, Carl Ware, Andrew Godkin, Jens V. Stein, Gib Bogle, Awen Gallimore
Publikováno v:
Cancer Research Communications. 2:1641-1656
High endothelial venules (HEV) are specialized post capillary venules that recruit naïve T cells and B cells into secondary lymphoid organs (SLO) such as lymph nodes (LN). Expansion of HEV networks in SLOs occurs following immune activation to suppo
Autor:
Awen Gallimore, Gib Bogle, Jens V. Stein, Andrew Godkin, Carl Ware, Michelle Somerville, Sarah N. Lauder, Kathryn Smart, Inken Kelch, Emma Jones, Jun Abe, Stefan Milutinovic
LSFM imaging of Treg depleted and T-cell depleted fibrosarcomas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2ed8104e7626ae8079b272490919e5
https://doi.org/10.1158/2767-9764.22546256
https://doi.org/10.1158/2767-9764.22546256
Autor:
Awen Gallimore, Andrew Godkin, Robert Andrews, William J. Watkins, Matthew J. Smalley, Rhiannon French, James P. Hindley, Howard Kendrick, Stefan Milutinovic, Michelle Somerville, Sarah N. Lauder, Kathryn Smart, Emma Jones, Alexander Greenshields-Watson, Ana Pires
Supplementary Figures 1-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d486884604d87cab99475a87091a408
https://doi.org/10.1158/2326-6066.22543605.v1
https://doi.org/10.1158/2326-6066.22543605.v1
Autor:
Awen Gallimore, Gib Bogle, Jens V. Stein, Andrew Godkin, Carl Ware, Michelle Somerville, Sarah N. Lauder, Kathryn Smart, Inken Kelch, Emma Jones, Jun Abe, Stefan Milutinovic
High endothelial venules (HEV) are specialized post capillary venules that recruit naïve T cells and B cells into secondary lymphoid organs (SLO) such as lymph nodes (LN). Expansion of HEV networks in SLOs occurs following immune activation to suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e518ba5cab64bb4d5b9752e29a0b0da
https://doi.org/10.1158/2767-9764.c.6551132.v1
https://doi.org/10.1158/2767-9764.c.6551132.v1
Autor:
Awen Gallimore, Andrew Godkin, Robert Andrews, William J. Watkins, Matthew J. Smalley, Rhiannon French, James P. Hindley, Howard Kendrick, Stefan Milutinovic, Michelle Somerville, Sarah N. Lauder, Kathryn Smart, Emma Jones, Alexander Greenshields-Watson, Ana Pires
The nature of the tumor microenvironment (TME) influences the ability of tumor-specific T cells to control tumor growth. In this study, we performed an unbiased comparison of the TME of regulatory T-cell (Treg)–replete and Treg-depleted carcinogen-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd1b36ae44d938b2dc48a4d25e36406
https://doi.org/10.1158/2326-6066.c.6550332
https://doi.org/10.1158/2326-6066.c.6550332