Výsledky vyhledávání - "Sarah N. Isherwood"

Selective and interactive effects of D 2 receptor antagonism and positive allosteric mGluR4 modulation on waiting impulsivity

Autor: Anton Pekcec, Trevor W. Robbins, Sarah N. Isherwood, Janet R. Nicholson, Jeffrey W. Dalley

Publikováno v: Neuropharmacology

Background Metabotropic glutamate receptor 4 (mGluR4) and dopamine D2 receptors are specifically expressed within the indirect pathway neurons of the striato-pallidal-subthalamic pathway. This unique expression profile suggests that mGluR4 and D2 rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eee35d2249481c8f378f890bc0c7db3
https://doi.org/10.1016/j.neuropharm.2017.05.006

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Bidirectional variation in glutamate efflux in the medial prefrontal cortex induced by selective positive and negative allosteric mGluR5 modulators

Autor: Trevor W. Robbins, Sarah N. Isherwood, Anton Pekcec, Jeffrey W. Dalley

Publikováno v: Journal of Neurochemistry

Dysregulation of prefrontal cortical glutamatergic signalling via NMDA receptor hypofunction has been implicated in cognitive dysfunction and impaired inhibitory control in such neuropsychiatric disorders as schizophrenia, attention‐deficit hyperac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a6783388ff9e6dc1aa940ef606f382
https://www.repository.cam.ac.uk/handle/1810/270877

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Dissociable effects of mGluR5 allosteric modulation on distinct forms of impulsivity in rats: interaction with NMDA receptor antagonism

Autor: Anton Pekcec, Jeffrey W. Dalley, Sarah N. Isherwood, Trevor W. Robbins, Janet R. Nicholson

Publikováno v: Psychopharmacology. 232(18)

Impaired N-methyl-d-aspartate (NMDA) receptor signalling underlies several psychiatric disorders that express high levels of impulsivity. Although synergistic interactions exist between NMDA receptors and metabotropic glutamate receptor 5 (mGluR5), t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c10037de1c7875e5823c18d526e114
https://pubmed.ncbi.nlm.nih.gov/26063678

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