Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Sarah N. Campion"'
Autor:
Michelle R. Garnsey, Aaron C. Smith, Jana Polivkova, Autumn L. Arons, Guoyun Bai, Caroline Blakemore, Markus Boehm, Leanne M. Buzon, Sarah N. Campion, Matthew Cerny, Shiao-Chi Chang, Karen Coffman, Kathleen A. Farley, Kari R. Fonseca, Kristen K. Ford, Jeonifer Garren, Jimmy X. Kong, Martin R. M. Koos, Daniel W. Kung, Yajing Lian, Monica M. Li, Qifang Li, Luis A. Martinez-Alsina, Rebecca O’Connor, Kevin Ogilvie, Kiyoyuki Omoto, Brian Raymer, Matthew R. Reese, Tim Ryder, Lacey Samp, Kimberly A. Stevens, Daniel W. Widlicka, Qingyi Yang, Kaicheng Zhu, Jean-Philippe Fortin, Matthew F. Sammons
Publikováno v:
Journal of Medicinal Chemistry. 66:3195-3211
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ba50d658838cab5c2164045c8015f51
https://doi.org/10.1021/acs.jmedchem.2c02012
https://doi.org/10.1021/acs.jmedchem.2c02012
Autor:
Sarah N. Campion, William S. Nowland, Kathryn Gropp, Chang‐Ning Liu, Hayley N. Ritenour, Jameel Syed, Natasha Catlin, Christine M. Stethem, Timothy M. Coskran, Gregg D. Cappon
Publikováno v:
Birth Defects Research. 114:863-872
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e36fa20723992a64412fab44ef95dfc4
https://doi.org/10.1002/bdr2.2071
https://doi.org/10.1002/bdr2.2071
Autor:
Natasha R Catlin, Christopher J Bowman, Sarah N Campion, Elise M Lewis, William S Nowland, Christine Stethem, Gregg D Cappon
Publikováno v:
Toxicological Sciences. 189:225-236
Ervogastat (PF-06865571) is a small molecule diacylglycerol acyltransferase 2 (DGAT2) inhibitor being developed for the oral treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis. DGAT2 is a key enzyme in triglyceride synthesis in tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8406685f49264eb55b560fab52e2d7d6
https://doi.org/10.1093/toxsci/kfac077
https://doi.org/10.1093/toxsci/kfac077
Autor:
Sarah N. Campion, Christopher J. Bowman, Antje Fuchs, David Karanian, Payal Rana, Gregg D. Cappon
Publikováno v:
Birth defects researchREFERENCES.
Achondroplasia is an autosomal disorder caused by point mutation in the gene encoding fibroblast growth factor receptor 3 (FGFR3) and resulting in gain of function. Recifercept is a potential disease modifying treatment for achondroplasia and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3261062f97b1f60d4f7ae6a010cfedae
https://pubmed.ncbi.nlm.nih.gov/36367445
https://pubmed.ncbi.nlm.nih.gov/36367445
Autor:
William S. Nowland, Steven W. Kumpf, Trenton T. Ross, Christopher J. Bowman, Gregg D. Cappon, Donald S Stedman, Scott D Davenport, William P. Esler, Christine Stethem, Natasha R. Catlin, Elise M. Lewis, Sarah N. Campion
Publikováno v:
Toxicological Sciences. 179:183-194
Acetyl-CoA carboxylase (ACC) is an enzyme within the de novo lipogenesis (DNL) pathway and plays a role in regulating lipid metabolism. Pharmacologic ACC inhibition has been an area of interest for multiple potential indications including oncology, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6d9eb6a77626c055c46264ceba500b
https://doi.org/10.1093/toxsci/kfaa169
https://doi.org/10.1093/toxsci/kfaa169
Autor:
Sarah N. Campion, Claudia Lindemann, Gregg D. Cappon, Christopher J. Bowman, Rani S. Sellers, Jan Diekmann, Cynthia M. Rohde, Marie Bouressam, Mark Cutler, Natasha R. Catlin
Publikováno v:
Reproductive Toxicology (Elmsford, N.y.)
BNT162b2 is a vaccine developed to prevent coronavirus disease 2019 (COVID-19). BNT162b2 is a lipid nanoparticle formulated nucleoside-modified messenger RNA (mRNA) encoding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3395824bfd2b8be7cdacd6a416a8a3e7
https://pubmed.ncbi.nlm.nih.gov/34058573
https://pubmed.ncbi.nlm.nih.gov/34058573
Autor:
Christopher J. Bowman, William S. Nowland, Sarah N. Campion, Christine Stethem, Natasha R. Catlin, Gregg D. Cappon
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 99
Traditionally, understanding potential developmental toxicity from pharmaceutical exposures has been based on the results of ICH guideline studies in two species. However, support is growing for the use of weight of evidence approaches when communica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e412131819c01e534d4a201a59f3025d
https://pubmed.ncbi.nlm.nih.gov/33065206
https://pubmed.ncbi.nlm.nih.gov/33065206
Autor:
Stavra A. Xanthakos, Robert P. Erickson, Rhiannon N. Hardwick, Hassan H. A-Kader, Mark J. Canet, Nathan J. Cherrington, Amy M. Bataille, José E. Manautou, Daniel W. Ferreira, Sarah N. Campion, Matthew D. Merrell
Publikováno v:
Drug Metabolism and Disposition. 43:829-835
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, representing a spectrum of liver pathologies that include simple hepatic steatosis and the more advanced nonalcoholic steatohepatitis (NASH). The current study was con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1cfa7b4b20d2563371cecd87810bc9
https://doi.org/10.1124/dmd.114.062703
https://doi.org/10.1124/dmd.114.062703
Autor:
William S. Nowland, Timothy M. Coskran, Elsa G. Barbacci-Tobin, Timothy R. Winton, Steven W. Kumpf, Sarah N. Campion, Robert E. Chapin, Scott Davenport, Christopher Houle, Randal D. Streck, David Karanian
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:325-332
Treatment-induced epididymal inflammation and granuloma formation is only an occasional problem in preclinical drug development, but it can effectively terminate the development of that candidate molecule. Screening for backup molecules without that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e19af30dcb0ea577014281fc8d29754d
https://doi.org/10.1002/bdrb.21115
https://doi.org/10.1002/bdrb.21115
Comparative assessment of the timing of sexual maturation in male Wistar Han and Sprague-Dawley rats
Autor:
Sarah N. Campion, William S. Nowland, Timothy R. Winton, Gregg D. Cappon, Rebecca Koitz, Mark E. Hurtt, Francisco R. Carvallo, Raul T Jamon, David Beauchamp, Robert E. Chapin
Publikováno v:
Reproductive Toxicology. 38:16-24
Given the increasing use of Wistar Han (WH) rats in regulatory toxicology studies, these studies were performed to characterize the onset of sexual maturation in maturing WH rats as compared to Sprague-Dawley (SD) rats. Beginning on postnatal day (PN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d33db1502377b6b153efbb7b70ded12
https://doi.org/10.1016/j.reprotox.2013.02.003
https://doi.org/10.1016/j.reprotox.2013.02.003