Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sarah Mole"'
Autor:
Wouter tenVoorde, Chika Akinseye, Ismahaan Abdisalaam, Selinde Wind, Naomi Klarenbeek, Menthe Bergmans, Martijn vanDoorn, Robert Rissmann, Rejbinder Kaur, Sarah Hotee, Katie Foster, Arati Nair, Lea Fortunato, Colin Macphee, Sarah Mole, Katrine Baumann, Richard Brigandi
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 10, Pp 1856-1865 (2023)
Abstract Pharmacological challenge models are deployed to evaluate drug effects during clinical development. Intradermal injection of Substance P (SP) neuropeptide, a potential challenge agent for investigating local mediators, is associated with whe
Externí odkaz:
https://doaj.org/article/08287e6b2cc64b848f3fdbb071032292
Autor:
Andrew Stevenson, Hegel Hernandez-Lopez, Sally Roberts, Megan E Griffiths, Sarah Mole, Arwa Ali A. Faizo, Sheila V. Graham
Publikováno v:
The Journal of General Virology
The infectious life cycle of human papillomaviruses (HPVs) is tightly linked to keratinocyte differentiation. Evidence suggests a sophisticated interplay between host gene regulation and virus replication. Alternative splicing is an essential process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8653973ad416f8ded9bfed21a4f776
http://europepmc.org/articles/PMC7414453
http://europepmc.org/articles/PMC7414453
Autor:
Anthony Cahn, Steven W. Yancey, Sarah Mole, Nicholas P. Bird, Yau Lun Man, Dave Singh, Kelly Hardes, Isabelle Pouliquen, Rainard Fuhr
Publikováno v:
British journal of clinical pharmacology. 88(2)
Aims GSK3511294 is a humanized anti-interleukin (IL)-5 monoclonal antibody (mAb) engineered for extended half-life and improved IL-5 affinity versus other anti-IL-5 mAbs. This study examined its safety, tolerability, pharmacokinetics (PK) and effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85d115a89802b9c437b97969ae691fa
https://pubmed.ncbi.nlm.nih.gov/34292606
https://pubmed.ncbi.nlm.nih.gov/34292606
Autor:
Sarah Mole, A Harry, S Waite, Aili L. Lazaar, C Faulenbach, M Müller, JM Hohlfeld, Misba Beerahee, Andrew Fowler, David J. Behm, P Badorrek, Sarah Hotee, J Warburton
Publikováno v:
Pulmonary hypertension: advances in diagnosis and treatment.
Introduction and objectives Acute Respiratory Distress Syndrome (ARDS) is associated with increased pulmonary vascular permeability. In the lung, transient receptor potential vanilloid 4 (TRPV4), a Ca2+-permeable cation channel, is a known regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a9ce1c8c610b867615926c1e2eec93c
https://doi.org/10.1136/thorax-2019-btsabstracts2019.258
https://doi.org/10.1136/thorax-2019-btsabstracts2019.258
Autor:
Sarah Mole, Sarah Hotee, Meike Müller, Cornelia Faulenbach, Sarah Waite, Misba Beerahee, Joseph Warburton, Philipp Badorrek, Aili L. Lazaar, Anya Harry, Andrew Fowler, David J. Behm, Jens M. Hohlfeld
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 64:101977
Background Acute Respiratory Distress Syndrome (ARDS) is associated with increased pulmonaryvascular permeability. In the lung, transient receptor potential vanilloid 4 (TRPV4), a Ca2+-permeable cation channel, is a regulator of endothelial permeabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e653f3bd653f10419fbead0c9d70664
https://doi.org/10.1016/j.pupt.2020.101977
https://doi.org/10.1016/j.pupt.2020.101977
Publikováno v:
Oral and Maxillofacial Surgery Cases, Vol 9, Iss 2, Pp 100318- (2023)
This is the first reported case of medication-related osteonecrosis of the jaw (MRONJ) resulting from the use of romosozumab, a new anti-resorptive medication that functions through inhibition of sclerostin. It was approved by the FDA in 2019, and me
Externí odkaz:
https://doaj.org/article/c932298e0f9a447d87539199d7040f24
Autor:
Steven G. Milligan, Sheila V. Graham, David Millan, Melanie McFarlane, Sarah Mole, Thanaporn Chuen-Im
Publikováno v:
The Journal of Pathology. 219:383-391
The most prevalent human papillomaviruses (HPVs) causing cervical disease are the 'high-risk' HPV types 16 and 18. All papillomaviruses express a transcription factor, E2, that can regulate viral and cellular gene expression. Recently, we demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::187526be8971dcebc08f4afc877aa350
https://doi.org/10.1002/path.2608
https://doi.org/10.1002/path.2608
Publikováno v:
Virology
The life cycle of human papillomavirus type 16 (HPV16) is intimately linked to differentiation of the epithelium it infects, and late events in the life cycle are restricted to the suprabasal layers. Here we have used 5′RACE of polyadenylated RNA i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288c53cadb1f77bfb8356e88c39d8dcb
https://doi.org/10.1016/j.virol.2006.10.012
https://doi.org/10.1016/j.virol.2006.10.012
Publikováno v:
Biochemical Society Transactions. 34:1145-1147
HPV-16 (human papillomavirus type 16) is a small dsDNA (double-stranded DNA) virus which infects mucosal epithelial tissue of the cervix. Epithelial tissue is composed of a basal layer of cells, capable of division, and a number of suprabasal layers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d9d1ce951e1f463678715cfc11071a
https://doi.org/10.1042/bst0341145
https://doi.org/10.1042/bst0341145