Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sarah Melzer"'
Autor:
Reto B Cola, Salome N Niethammer, Preethi Rajamannar, Andrea Gresch, Musadiq A Bhat, Kevin Assoumou, Elyse T Williams, Patrick Hauck, Nina Hartrampf, Dietmar Benke, Miriam Stoeber, Gil Levkowitz, Sarah Melzer, Tommaso Patriarchi
Publikováno v:
eLife, Vol 13 (2024)
Class-B1 G-protein-coupled receptors (GPCRs) are an important family of clinically relevant drug targets that remain difficult to investigate via high-throughput screening and in animal models. Here, we engineered PAClight1P78A, a novel genetically e
Externí odkaz:
https://doaj.org/article/83a204a88f8b464d90811cb0b5e39796
Autor:
Yixin Wu, Mingzheng Wu, Abraham Vázquez-Guardado, Joohee Kim, Xin Zhang, Raudel Avila, Jin-Tae Kim, Yujun Deng, Yongjoon Yu, Sarah Melzer, Yun Bai, Hyoseo Yoon, Lingzi Meng, Yi Zhang, Hexia Guo, Liu Hong, Evangelos E. Kanatzidis, Chad R. Haney, Emily A. Waters, Anthony R. Banks, Ziying Hu, Ferrona Lie, Leonardo P. Chamorro, Bernardo L. Sabatini, Yonggang Huang, Yevgenia Kozorovitskiy, John A. Rogers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Wireless delivery of both light and pharmacological agents is important for optogenetic and other mechanistic experiments in the brain. Here the authors present a wireless real-time programmable optofluidic platform that enables optogenetics and phot
Externí odkaz:
https://doaj.org/article/9151205514be4074aebbd044022a664b
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 1045-1055 (2017)
Summary: The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output. Excitatory neurons have been thought to be the only source of
Externí odkaz:
https://doaj.org/article/76adefcec42b49749470a381dfbef8c5
Autor:
Hannah Monyer, Sarah Melzer
Publikováno v:
Nature Reviews Neuroscience. 21:499-515
It is still widely thought that cortical projections to distant brain areas derive by and large from glutamatergic neurons. However, an increasing number of reports provide evidence that cortical GABAergic neurons comprise a smaller population of 'pr
Autor:
Minsuk Hyun, Sarah Melzer, Malika R. Gregory, Grace O. Mizuno, Lin Tian, Kee Wui Huang, Beatrice Righetti, James Levasseur, Bernardo L. Sabatini, Elena Newmark, Adrienne C. Philson, Eleonora Quiroli
Publikováno v:
Cell
Cell, vol 184, iss 22
Cell, vol 184, iss 22
SummaryDisinhibitory neurons throughout the mammalian cortex are powerful enhancers of circuit excitability and plasticity. The differential expression of neuropeptide receptors in disinhibitory, inhibitory and excitatory neurons suggests that each c
Autor:
Connor Johnson, Lisa N. Kretsge, William W. Yen, Balaji Sriram, Alexandra O’Connor, Ruichen Sky Liu, Jessica C. Jimenez, Rhushikesh A. Phadke, Kelly K. Wingfield, Charlotte Yeung, Tushare J. Jinadasa, Thanh P. H. Nguyen, Eun Seon Cho, Erelle Fuchs, Eli D. Spevack, Berta Escude Velasco, Frances S. Hausmann, Luke A. Fournier, Alison Brack, Sarah Melzer, Alberto Cruz-Martín
Publikováno v:
Molecular psychiatry. 27(5)
A hallmark of the anterior cingulate cortex (ACC) is its functional heterogeneity. Functional and imaging studies revealed its importance in the encoding of anxiety-related and social stimuli, but it is unknown how microcircuits within the ACC encode
Publikováno v:
Neuron
Summary Layer II (LII) of the medial entorhinal cortex (MEC) comprises grid cells that support spatial navigation. The firing pattern of grid cells might be explained by attractor dynamics in a network, which requires either direct excitatory connect
Autor:
Isabel Beets, Gáspár Jékely, Sara A. Haddad, Joris M. Koene, Ilona C. Grunwald Kadow, Sarah Melzer, Lindy Holden-Dye
Publikováno v:
Jékely, G, Melzer, S, Beets, I, Kadow, I C G, Koene, J, Haddad, S & Holden-Dye, L 2018, ' The long and the short of it-a perspective on peptidergic regulation of circuits and behaviour ', Journal of Experimental Biology, vol. 221, no. 3, 166710, pp. 1-14 . https://doi.org/10.1242/jeb.166710
Neuropeptides are the most diverse class of chemical modulators in nervous systems. They contribute to extensive modulation of circuit activity and have profound influences on animal physiology. Studies on invertebrate model organisms, including the
Publikováno v:
Current Opinion in Neurobiology. 23:179-186
GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the adult brain. Studies on GABAergic cells have focused almost exclusively on local interneurons neglecting those inhibitory neurons projecting to different brain areas, the '
Autor:
Antonio Caputi, Elke C. Fuchs, Miles A. Whittington, Marina Eliava, Magdalena Michael, Hannah Monyer, Sarah Melzer
Publikováno v:
Science
Inhibiting the Inhibitors Excitatory neurons in the hippocampus and entorhinal cortex are under control of local γ-aminobutyric acid–releasing (GABAergic) interneurons that are the major source of inhibition in the adult brain. In contrast to the