Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sarah Mellor"'
Autor:
James Spicer, Bristi Basu, Ana Montes, Udai Banerji, Rebecca Kristeleit, Rowan Miller, Gareth J. Veal, Christopher J. Corrigan, Stephen J. Till, Mariangela Figini, Silvana Canevari, Claire Barton, Paul Jones, Sarah Mellor, Simon Carroll, Chris Selkirk, George Nintos, Vineet Kwatra, Ionut-Gabriel Funingana, Gary Doherty, Hannah J. Gould, Giulia Pellizzari, Mano Nakamura, Kristina M. Ilieva, Atousa Khiabany, Chara Stavraka, Jitesh Chauhan, Cheryl Gillett, Sarah Pinder, Heather J. Bax, Debra H. Josephs, Sophia N. Karagiannis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract All antibodies approved for cancer therapy are monoclonal IgGs but the biology of IgE, supported by comparative preclinical data, offers the potential for enhanced effector cell potency. Here we report a Phase I dose escalation trial (NCT025
Externí odkaz:
https://doaj.org/article/10c6fe5134614037a52da348794ee12d
Autor:
Udai Banerji, Michelle D. Garrett, Florence I. Raynaud, Karen E. Swales, Sarah Mellor, Gavin Halbert, Stephanie Traub, Paul Jones, Victoria Sanz-Moreno, Oscar Maiques, Roberta Ferraldeschi, Simone Jueliger, Shaun Decordova, Ruth Ruddle, Alvaro H. Ingles Garces, Jessica S. Brown, Joaquin Mateo, Dionysis Papadatos-Pastos, Rajiv Kumar, Robert McLeod
Purpose:AT13148 is an oral AGC kinase inhibitor, which potently inhibits ROCK and AKT kinases. In preclinical models, AT13148 has been shown to have antimetastatic and antiproliferative activity.Patients and Methods:The trial followed a rolling six d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a333c1f82c5ff3931176d17bb6ff2c
https://doi.org/10.1158/1078-0432.c.6529065.v1
https://doi.org/10.1158/1078-0432.c.6529065.v1
Autor:
Udai Banerji, Michelle D. Garrett, Florence I. Raynaud, Karen E. Swales, Sarah Mellor, Gavin Halbert, Stephanie Traub, Paul Jones, Victoria Sanz-Moreno, Oscar Maiques, Roberta Ferraldeschi, Simone Jueliger, Shaun Decordova, Ruth Ruddle, Alvaro H. Ingles Garces, Jessica S. Brown, Joaquin Mateo, Dionysis Papadatos-Pastos, Rajiv Kumar, Robert McLeod
Inclusion/Exclusion Criteria and Pharmacokinetic Analytical Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5127ad704e76e04993609e6ace90960e
https://doi.org/10.1158/1078-0432.22475382
https://doi.org/10.1158/1078-0432.22475382
Autor:
Udai Banerji, Michelle D. Garrett, Florence I. Raynaud, Karen E. Swales, Sarah Mellor, Gavin Halbert, Stephanie Traub, Paul Jones, Victoria Sanz-Moreno, Oscar Maiques, Roberta Ferraldeschi, Simone Jueliger, Shaun Decordova, Ruth Ruddle, Alvaro H. Ingles Garces, Jessica S. Brown, Joaquin Mateo, Dionysis Papadatos-Pastos, Rajiv Kumar, Robert McLeod
Relationship between dose and AUC/Cmax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680ddacf31e0bd6d533d55ce226c23b9
https://doi.org/10.1158/1078-0432.22475379
https://doi.org/10.1158/1078-0432.22475379
Autor:
Florence I. Raynaud, Stephanie Traub, Ruth Ruddle, Alvaro Henrique Ingles Garces, Paul W. Jones, Shaun Decordova, Rajiv Kumar, Gavin Halbert, Sarah Mellor, Victoria Sanz-Moreno, Oscar Maiques, Jessica S. Brown, Simone Jueliger, Dionysis Papadatos-Pastos, Robert McLeod, Roberta Ferraldeschi, Udai Banerji, Joaquin Mateo, Michelle D. Garrett, Karen E Swales
Publikováno v:
Clin Cancer Res
Purpose: AT13148 is an oral AGC kinase inhibitor, which potently inhibits ROCK and AKT kinases. In preclinical models, AT13148 has been shown to have antimetastatic and antiproliferative activity. Patients and Methods: The trial followed a rolling si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169e545f7b076fa76c7cb49f52418312
https://strathprints.strath.ac.uk/74853/1/McLeod_etal_CCR_2020_First_in_human_study_of_AT13148_a_dual_ROCK_AKT_inhibitor.pdf
https://strathprints.strath.ac.uk/74853/1/McLeod_etal_CCR_2020_First_in_human_study_of_AT13148_a_dual_ROCK_AKT_inhibitor.pdf
Autor:
Sarah Mellor, Jitesh Chauhan, Atousa Khiabany, Heike Lentfer, Gareth J. Veal, George Nintos, Bristi Basu, Susan Brook, Mano Nakamura, Sophia N. Karagiannis, Katie Stoddart, Kristina M. Ilieva, Giulia Pellizzari, Stephen J. Till, Ionut G. Funingana, Chara Stavraka, Debra H. Josephs, Annie Griffin, Kam Zaki, Ana Montes, Paul W. Jones, James Spicer, Christopher Selkirk, Sarah E Pinder, Heather J. Bax, Simon Carroll, Amy Pope, Joo Ern Ang, Timothy Brier, Natalie Woodman, Claire Barton, Rebecca Kristeleit, Christopher Corrigan, Udai Banerji, Hannah J. Gould
Publikováno v:
Cancer Research. 80:CT141-CT141
Background: All antibodies approved for the treatment of cancer are monoclonal IgGs, and no IgE therapy has yet been tested in humans. The biology of IgE, compared with IgG, offers potential for enhanced immune surveillance and superior effector cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d61014306d38b8a521950b7e7dfeedf8
https://doi.org/10.1158/1538-7445.am2020-ct141
https://doi.org/10.1158/1538-7445.am2020-ct141
Autor:
Ruth H. Green, Maria Shelley, Dominick E. Shaw, Mike Thomas, Beverley Hargadon, Ian D. Pavord, Mike A. Berry, Sue McKenna, Sarah Mellor
BACKGROUND: Most patients with asthma are managed exclusively in primary care. Little is known about the patterns of airway dysfunction in these patients and how these relate to other aspects of the disease. AIMS: We set out to assess this in a cross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea025a325175ef074f7933af6b964604
https://doi.org/10.4104/pcrj.2012.00057
https://doi.org/10.4104/pcrj.2012.00057
Autor:
Keith Pohl, Colin Deane, David C. Rees, Sarah Mellor, Sandra O'Driscoll, Sue Height, David Goss, Moira C. Dick
Publikováno v:
Archives of Disease in Childhood. 93:138-141
Objective: To assess the role. of transcranial Doppler (TCD) scanning in assessing the risk of stroke in children with HbSC disease. TCD scanning has an established role in primary stroke prevention in sickle cell anaemia (HbSS) but its value in HbSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::752d15f5d0b2441fac55d2dbcfcd8c7b
https://doi.org/10.1136/adc.2007.125799
https://doi.org/10.1136/adc.2007.125799
Autor:
Dominick E. Shaw, Andrew J. Wardlaw, Robert K McKinley, Gillian Watkin, Mike Thomas, Sarah Mellor, Elisabeth Holloway, Ian D. Pavord, Jane Scullion, David Price
Publikováno v:
Thorax. 64(1)
BACKGROUND: The effect of breathing modification techniques on asthma symptoms and objective disease control is uncertain. METHODS: A prospective, parallel group, single-blind, randomised controlled trial comparing breathing training with asthma educ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b2190b65dc27f37298ebecc396aec6
http://ora.ox.ac.uk/objects/uuid:6d33f115-922b-4664-b024-0ceb353d0421
http://ora.ox.ac.uk/objects/uuid:6d33f115-922b-4664-b024-0ceb353d0421
Autor:
Colin R, Deane, David, Goss, Sandra, O'Driscoll, Sarah, Mellor, Keith R E, Pohl, Moira C, Dick, Sue E, Height, David C, Rees
Publikováno v:
Archives of disease in childhood. 93(2)
To assess the role of transcranial Doppler (TCD) scanning in assessing the risk of stroke in children with haemoglobin SC (HbSC) disease. TCD scanning has an established role in primary stroke prevention in sickle cell anaemia but its value in HbSC i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::034c4f96d4a888b786bdc82c594f850d
https://pubmed.ncbi.nlm.nih.gov/17925326
https://pubmed.ncbi.nlm.nih.gov/17925326