Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Sarah Melissa P. Jacobo"'
1
N-Glycosylation affects the stability and barrier function of the MUC16 mucin
Autor: Sylvain Lehoux, Pablo Argüeso, Nicole M. McColgan, Takazumi Taniguchi, Jerome Mauris, Sarah Melissa P. Jacobo, Ashley M. Woodward, Paula Magnelli
Publikováno v: Journal of Biological Chemistry. 292:11079-11090
Transmembrane mucins are highly O-glycosylated glycoproteins that coat the apical glycocalyx on mucosal surfaces and represent the first line of cellular defense against infection and injury. Relatively low levels of N-glycans are found on transmembr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f22882ebe3387d895d7bd80cb44d3cc
https://doi.org/10.1074/jbc.m116.770123
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2
Age-Related Macular Degeneration-Associated Silent Polymorphisms in HtrA1 Impair Its Ability To Antagonize Insulin-Like Growth Factor 1
Autor: Margaret M. DeAngelis, Ivana K. Kim, Andrius Kazlauskas, Sarah Melissa P. Jacobo
Publikováno v: Molecular and Cellular Biology. 33:1976-1990
Synonymous single nucleotide polymorphisms (SNPs) within a transcript's coding region produce no change in the amino acid sequence of the protein product and are therefore intuitively assumed to have a neutral effect on protein function. We report th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ef0ffa3af410743ea30a342c0e0739
https://doi.org/10.1128/mcb.01283-12
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3
Cav1.2 and Cav1.3 Are Differentially Coupled to Glucagon-Like Peptide-1 Potentiation of Glucose-Stimulated Insulin Secretion in the Pancreatic β-Cell Line INS-1
Autor: Sarah Melissa P. Jacobo, Gregory H. Hockerman, Marcy L. Guerra
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 331:724-732
The incretin peptides, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), potentiate glucose-stimulated insulin secretion (GSIS) and beta-cell proliferation and differentiation. Ca(2+) influx via voltage-gated L-t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d8845bb0ffd7ac235404eeee6a6f4c
https://doi.org/10.1124/jpet.109.158519
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4
Insulin-like growth factor 1 (IGF-1) stabilizes nascent blood vessels
Autor: Andrius Kazlauskas, Sarah Melissa P. Jacobo
Publikováno v: The Journal of biological chemistry. 290(10)
Here we report that VEGF-A and IGF-1 differ in their ability to stabilize newly formed blood vessels and endothelial cell tubes. Although VEGF-A failed to support an enduring vascular response, IGF-1 stabilized neovessels generated from primary endot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a581bd47646cd7fed32463fcca7dfc2
https://pubmed.ncbi.nlm.nih.gov/25564613
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5
Differential Modulation of Cav1.2 and Cav1.3-Mediated Glucose-Stimulated Insulin Secretion by cAMP in INS-1 Cells: Distinct Roles for Exchange Protein Directly Activated by cAMP 2 (Epac2) and Protein Kinase A
Autor: Nathan Hilliard, Gregory H. Hockerman, Sarah Melissa P. Jacobo, Guohong Liu
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 318:152-160
Using insulin-secreting cell line (INS)-1 cells stably expressing dihydropyridine-insensitive mutants of either Cav1.2 or Cav1.3, we previously demonstrated that Cav1.3 is preferentially coupled to insulin secretion and [Ca2+]i oscillations stimulate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e7b82ce8d94bca0cb7ce20d58db1fb
https://doi.org/10.1124/jpet.105.097477
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6
ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity
Autor: Maximilian J, Gerhardt, Joseph A, Marsh, Margaux, Morrison, Andrius, Kazlauskas, Arogya, Khadka, Stephan, Rosenkranz, Margaret M, DeAngelis, Magali, Saint-Geniez, Sarah Melissa P, Jacobo
Publikováno v: Journal of molecular cell biology
J Mol Cell Biol
High temperature requirement A1 (HtrA1) belongs to an ancient protein family that is linked to various human disorders. The precise role of exon 1-encoded N-terminal domains and how these influence the biological functions of human HtrA1 remain elusi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c1ba9f05690c8c15604effe82d3098
https://doi.org/10.1093/jmcb/mjx040
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7
The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts
Autor: Julie A. Przybyla, Guohong Liu, Marcy L. Guerra, Val J. Watts, Gregory H. Hockerman, Rachel E. Jarrard, Sarah Melissa P. Jacobo
Publikováno v: The Journal of pharmacology and experimental therapeutics. 330(1)
L-type Ca(2+) channels play a key role in the integration of physiological signals regulating insulin secretion that probably requires their localization to specific subdomains of the plasma membrane. We investigated the role of the intracellular II-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c57af1d3d9f77fc535d3aee6e9f5686
https://pubmed.ncbi.nlm.nih.gov/19351867
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