Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sarah Melamed"'
Autor:
Jeremy Garb, Anna Lopatina, Aude Bernheim, Mindaugas Zaremba, Virginijus Siksnys, Sarah Melamed, Azita Leavitt, Adi Millman, Gil Amitai, Rotem Sorek
Publikováno v:
Nature Microbiology. 7:1849-1856
Autor:
Francois Rousset, Erez Yirmiya, Shahar Nesher, Alexander Brandis, Tevie Mehlman, Maxim Itkin, Sergey Malitsky, Adi Millman, Sarah Melamed, Rotem Sorek
SummaryDuring viral infection, cells can deploy immune strategies that deprive viruses of molecules essential for their replication. In this study, we report a family of immune effectors in bacteria which, in response to phage infection, degrade cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b69114cf8e4968d06e7faa16538f37b9
https://doi.org/10.1101/2023.01.24.525353
https://doi.org/10.1101/2023.01.24.525353
Autor:
Avigail Stokar-Avihail, Taya Fedorenko, Jeremy Garb, Azita Leavitt, Adi Millman, Gabriela Shulman, Nicole Wojtania, Sarah Melamed, Gil Amitai, Rotem Sorek
Over the past few years, numerous anti-phage defense systems have been discovered in bacteria. While the mechanism of defense for some of these systems is understood, a major unanswered question is how these systems sense phage infection. To systemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e652f2e651139376317b50422c9467fe
https://doi.org/10.1101/2022.08.27.505566
https://doi.org/10.1101/2022.08.27.505566
Autor:
Brianna Duncan-Lowey, Nitzan Tal, Alex G. Johnson, Shaun Rawson, Megan L. Mayer, Shany Doron, Adi Millman, Sarah Melamed, Taya Fedorenko, Assaf Kacen, Gil Amitai, Rotem Sorek, Philip J. Kranzusch
SummaryRADAR is a two-protein bacterial defense system which was reported to defend against phage by ‘editing’ messenger RNA. Here we determine cryo-EM structures of the RADAR defense complex, revealing RdrA as a heptameric, two-layered AAA+ ATPa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::517163ced1057ca0d47f415f233c25c2
https://doi.org/10.1101/2022.08.17.504323
https://doi.org/10.1101/2022.08.17.504323
Autor:
Avigail Stokar-Avihail, Taya Fedorenko, Jens Hör, Jeremy Garb, Azita Leavitt, Adi Millman, Gabriela Shulman, Nicole Wojtania, Sarah Melamed, Gil Amitai, Rotem Sorek
Publikováno v:
Cell. 186:1863-1876.e16
Autor:
Adi Millman, Sarah Melamed, Azita Leavitt, Shany Doron, Aude Bernheim, Jens Hör, Jeremy Garb, Nathalie Bechon, Alexander Brandis, Anna Lopatina, Gal Ofir, Dina Hochhauser, Avigail Stokar-Avihail, Nitzan Tal, Saar Sharir, Maya Voichek, Zohar Erez, Jose Lorenzo M. Ferrer, Daniel Dar, Assaf Kacen, Gil Amitai, Rotem Sorek
Publikováno v:
Cell hostmicrobe. 30(11)
Bacterial anti-phage systems are frequently clustered in microbial genomes, forming defense islands. This property enabled the recent discovery of multiple defense systems based on their genomic co-localization with known systems, but the full arsena
Autor:
Adi Millman, Sarah Melamed, Azita Leavitt, Shany Doron, Aude Bernheim, Jens Hör, Anna Lopatina, Gal Ofir, Dina Hochhauser, Avigail Stokar-Avihail, Nitzan Tal, Saar Sharir, Maya Voichek, Zohar Erez, Jose Lorenzo M. Ferrer, Daniel Dar, Assaf Kacen, Gil Amitai, Rotem Sorek
Bacterial anti-phage defense systems are frequently clustered in microbial genomes, forming defense islands. This genomic property enabled the recent discovery of multiple defense systems based on their genomic co-localization with known systems, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d10facbfbe854430d95f6a2108fe4d17
https://doi.org/10.1101/2022.05.11.491447
https://doi.org/10.1101/2022.05.11.491447
Autor:
Brianna Duncan-Lowey, Nitzan Tal, Alex G. Johnson, Shaun Rawson, Megan L. Mayer, Shany Doron, Adi Millman, Sarah Melamed, Taya Fedorenko, Assaf Kacen, Alexander Brandis, Tevie Mehlman, Gil Amitai, Rotem Sorek, Philip J. Kranzusch
Publikováno v:
Cell. 186:987-998.e15
Autor:
Gil Amitai, Adi Millman, Carmel Avraham, Gilad Meitav, Sarah Melamed, Aude Bernheim, Helena Shomar, Gal Ofir, Nir Tal, Rotem Sorek, Masha M. Rosenberg
Publikováno v:
Nature
Viperin is an interferon-induced cellular protein that is conserved in animals1. It has previously been shown to inhibit the replication of multiple viruses by producing the ribonucleotide 3′-deoxy-3′,4′-didehydro (ddh)-cytidine triphosphate (d
Autor:
Nitzan Tal, Adi Millman, Avigail Stokar-Avihail, Taya Fedorenko, Azita Leavitt, Sarah Melamed, Erez Yirmiya, Carmel Avraham, Alexander Brandis, Tevie Mehlman, Gil Amitai, Rotem Sorek
Publikováno v:
Nature microbiology. 7(8)
DNA viruses and retroviruses consume large quantities of deoxynucleotides (dNTPs) when replicating. The human antiviral factor SAMHD1 takes advantage of this vulnerability in the viral lifecycle, and inhibits viral replication by degrading dNTPs into