Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sarah McGarrity"'
Autor:
Pär I. Johansson, Hanne H. Henriksen, Sigurður T. Karvelsson, Óttar Rolfsson, Martin Schønemann-Lund, Morten H. Bestle, Sarah McGarrity
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-14 (2024)
Abstract Sepsis is a major cause of death worldwide, with a mortality rate that has remained stubbornly high. The current gold standard of risk stratifying sepsis patients provides limited mechanistic insight for therapeutic targeting. An improved ab
Externí odkaz:
https://doaj.org/article/738699080381430d9b45ae0de27a6d7f
Autor:
Courtney A Copeland, Benjamin A Olenchock, David Ziehr, Sarah McGarrity, Kevin Leahy, Jamey D Young, Joseph Loscalzo, William M Oldham
Publikováno v:
eLife, Vol 12 (2023)
Hypoxia requires metabolic adaptations to sustain energetically demanding cellular activities. While the metabolic consequences of hypoxia have been studied extensively in cancer cell models, comparatively little is known about how primary cell metab
Externí odkaz:
https://doaj.org/article/22d0346cf34a4f7eae272e08bef916d3
Autor:
Thora Bjorg Sigmarsdottir, Sarah McGarrity, James T. Yurkovich, Óttar Rolfsson, Ólafur Eysteinn Sigurjónsson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Since their initial discovery in 1976, mesenchymal stem cells (MSCs) have been gathering interest as a possible tool to further the development and enhancement of various therapeutics within regenerative medicine. However, our current understanding o
Externí odkaz:
https://doaj.org/article/4719f0f069084b17be3552aa30376edd
Autor:
Adrián López García de Lomana, Arnar Ingi Vilhjálmsson, Sarah McGarrity, Rósa Sigurðardóttir, Ósk Anuforo, Alexía Rós Viktorsdóttir, Aris Kotronoulas, Andreas Bergmann, Leifur Franzson, Haraldur Halldórsson, Hanne H. Henriksen, Charles E. Wade, Pär Ingemar Johansson, Óttar Rolfsson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3162 (2022)
Disruption to endothelial cell homeostasis results in an extensive variety of human pathologies that are particularly relevant to major trauma. Circulating catecholamines, such as adrenaline and noradrenaline, activate endothelial adrenergic receptor
Externí odkaz:
https://doaj.org/article/cab676367f2749a5891e196438cbe300
Autor:
Þóra Sigmarsdóttir, Sarah McGarrity, Óttar Rolfsson, James T. Yurkovich, Ólafur E. Sigurjónsson
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the cor
Externí odkaz:
https://doaj.org/article/d108fcfe66af439fb9cad54dfeafff3b
Autor:
Sarah McGarrity, Ósk Anuforo, Haraldur Halldórsson, Andreas Bergmann, Skarphéðinn Halldórsson, Sirus Palsson, Hanne H. Henriksen, Pär Ingemar Johansson, Óttar Rolfsson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Endothelial dysfunction contributes to sepsis outcome. Metabolic phenotypes associated with endothelial dysfunction are not well characterised in part due to difficulties in assessing endothelial metabolism in situ. Here, we describe the con
Externí odkaz:
https://doaj.org/article/3346a06d5da14fb4a956f403770503f3
Metabolic and Transcriptional Changes across Osteogenic Differentiation of Mesenchymal Stromal Cells
Autor:
Thora Bjorg Sigmarsdottir, Sarah McGarrity, Adrián López García de Lomana, Aristotelis Kotronoulas, Snaevar Sigurdsson, James T. Yurkovich, Ottar Rolfsson, Olafur Eysteinn Sigurjonsson
Publikováno v:
Bioengineering, Vol 8, Iss 12, p 208 (2021)
Mesenchymal stromal cells (MSCs) are multipotent post-natal stem cells with applications in tissue engineering and regenerative medicine. MSCs can differentiate into osteoblasts, chondrocytes, or adipocytes, with functional differences in cells durin
Externí odkaz:
https://doaj.org/article/f9c9bba015c8413e9c2d45731bcca4fa
Autor:
Jakob Stensballe, Travis Nemkov, Ottar Rolfsson, Sarah McGarrity, Bernhard O. Palsson, Rósa S. Sigurðardóttir, Hanne H. Henriksen, Angelo D'Alessandro, Pär I. Johansson, Charles E. Wade
Publikováno v:
Annals of Surgery. 272:1140-1148
Objective Investigate the endothelial cell phenotype (s) that causes Shock-Induced Endotheliopathy in trauma. Background We have studied more than 2750 trauma patients and identified that patients with high circulating syndecan-1 (endothelial glycoca
Autor:
Courtney A. Copeland, Benjamin A. Olenchock, David R. Ziehr, Sarah McGarrity, Kevin Leahy, Jamey D. Young, Joseph Loscalzo, William M. Oldham
Hypoxia requires metabolic adaptations to sustain energetically demanding cellular activities. While the metabolic consequences of hypoxia have been studied extensively in cancer cell models, comparatively little is known about the metabolic response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3199d716a473802a11b532ec6481ffca
https://doi.org/10.1101/2020.09.21.306464
https://doi.org/10.1101/2020.09.21.306464
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2088
Metabolic network flux analysis uses genome-scale metabolic reconstructions to integrate transcriptomics, proteomics, and/or metabolomics data to allow for comprehensive interpretation of genotype to metabolic phenotype relationships. The compilation