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pro vyhledávání: '"Sarah Malpel"'
Publikováno v:
Developmental Biology. 273:402-415
Although respiratory tract defects that result from disruption of retinoic acid (RA) signaling have been widely reported, the mechanism by which endogenous RA regulates early lung morphogenesis is unknown. Here, we provide novel evidence that a major
Publikováno v:
Publons
Little is known about how retinoic acid (RA) synthesis, utilization and metabolism are regulated in the embryonic lung and how these activities relate to lung pattern formation. Here we report that early lung bud formation and subsequent branching mo
Autor:
Cherry Wongtrakool, T. Michael Underhill, Sarah Malpel, Jeff Sedita, Maria I. Ramirez, Julie Gorenstein, Wellington V. Cardoso
Publikováno v:
The Journal of biological chemistry. 278(47)
Although retinoic acid (RA) has been shown to be critical for lung development, little is known about when RA is required and the role of individual RA receptors (RAR) in this process. Previously reported data from an RA responsive element RARE-lacZ
Publikováno v:
Mechanisms of development. 86(1-2)
Cellular activities that lead to organogenesis are mediated by epithelial-mesenchymal interactions, which ultimately result from local activation of complex gene networks. Fibroblast growth factor (FGF) signaling is an essential component of the regu
Autor:
CassandraL. Smith, Sergey Lukyanov, JoelH. Graber, NataliaE. Broude, Eugene D. Sverdlov, Sarah Malpel, Niels Storm
Publikováno v:
Genetic analysis : biomolecular engineering. 15(2)
We previously described a targeted genomic differential display method (TGDD: Broude NE, Chandra A, Smith CL. Differential display of genomic subsets containing specific interspersed repeats. Proc. Natl. Acad. Sci. USA 1997;94:4548–53). In that met