Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sarah M. Orton"'
Autor:
Sarah M. Orton, Amarpreet Sangha, Mehul Gupta, Kristina Martens, Luanne M. Metz, A. P. J. de Koning, Gerald Pfeffer
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Multiple sclerosis (MS) is a chronic debilitating neurological condition with a wide range of phenotype variability. A complex interplay of genetic and environmental factors contributes to disease onset and progression in MS patients. Vitamin D defic
Externí odkaz:
https://doaj.org/article/43770c769a174fb0b2b1d65ed810dbc3
Autor:
Sreeram V Ramagopalan, Andrew P Morris, David A Dyment, Blanca M Herrera, Gabriele C DeLuca, Matthew R Lincoln, Sarah M Orton, Michael J Chao, A Dessa Sadovnick, George C Ebers
Publikováno v:
PLoS Genetics, Vol 3, Iss 9, Pp 1607-1613 (2007)
Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. HLA-DRB1*15 and HLA-DRB1*17-bearing haplotypes and interactions at the HLA-DRB1 locus increase ri
Externí odkaz:
https://doaj.org/article/ad8d63e5ccb14b6095f3b074af48426f
Autor:
Jordana T. Bell, Blanca M. Herrera, Gabriele C. DeLuca, Matthew R. Lincoln, Michael J. Chao, Sarah M. Orton, David A. Dyment, George C. Ebers, A. Dessa Sadovnick, Sreeram V. Ramagopalan
Multiple sclerosis (MS) is a complex trait in which HLA-DRB1*15 bearing MHC haplotypes increase risk of MS in people of Northern European descent. In this investigation of 7,334 individuals from 1,515 MS families, the largest cohort used to study the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582bbe0077e8eb4f1304c8eb6b2bc311
https://ora.ox.ac.uk/objects/uuid:c2433aff-bc91-4d90-b094-d7a1ac06deec
https://ora.ox.ac.uk/objects/uuid:c2433aff-bc91-4d90-b094-d7a1ac06deec
Autor:
Sreeram V. Ramagopalan, Andrea E. Para, A. Dessa Sadovnick, George C. Ebers, Sarah M. Orton, K M Morrison, Lahiru Handunnetthi, Adam E. Handel, Giulio Disanto
Multiple sclerosis (MS) is a complex trait with a significant genetic component. Recent work has implicated the ST8SIA1 gene, encoding a ganglioside synthase, in susceptibility to the disease, perhaps with a parent-of-origin effect. In this investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa119a861071ea364e1f0f1cb47e11b
https://doi.org/10.1016/j.jneuroim.2009.04.017
https://doi.org/10.1016/j.jneuroim.2009.04.017
Autor:
Sreeram V. Ramagopalan, Michael J. Chao, Matthew R. Lincoln, Gabriel Deluca, Blanca M. Herrera, Lahiru Handunetthi, Sarah M. Orton, George C. Ebers, A. Dessa Sadovnick
Publikováno v:
Human Molecular Genetics. 19:3679-3689
Multiple sclerosis (MS) susceptibility is characterized by maternal parent-of-origin effects and increased female penetrance. In 7796 individuals from 1797 MS families (affected individuals n = 2954), we further implicate epigenetic modifications wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a74f27bcb420bfe0be9f3256492244
https://doi.org/10.1093/hmg/ddq282
https://doi.org/10.1093/hmg/ddq282
Autor:
William Valdar, A. Dessa Sadovnick, George C. Ebers, Blanca M. Herrera, Kevin Atkins, David A. Dyment, Irene M. Yee, Maria G. Criscuoli, Sreeram V. Ramagopalan, Sarah M. Orton
Publikováno v:
Neuroepidemiology. 31:181-184
Background: Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. A clear maternal effect has been shown in several population-based studies. This parent-of-origin effect could result from factors operating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19cfb6439f73339c8eea931122d1e993
https://doi.org/10.1159/000154931
https://doi.org/10.1159/000154931
Autor:
George C. Ebers, Sarah M. Orton, Blanca M. Herrera, William Valdar, Sreeram V. Ramagopalan, Irene M. Yee, A. Dessa Sadovnick
Publikováno v:
The Lancet Neurology. 5:932-936
BACKGROUND: Incidence of multiple sclerosis is thought to be increasing, but this notion has been difficult to substantiate. In a longitudinal population-based dataset of patients with multiple sclerosis obtained over more than three decades, we did
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74ff5e929430b6899f8ac52feb60a0d
https://doi.org/10.1016/s1474-4422(06)70581-6
https://doi.org/10.1016/s1474-4422(06)70581-6
Autor:
Sreeram V. Ramagopalan, Gabriele C. DeLuca, Matthew R. Lincoln, A D Sadovnick, George C. Ebers, David A. Dyment, Sarah M. Orton, Blanca M. Herrera, Michael J. Chao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(18)
Multiple sclerosis (MS), a common central nervous system inflammatory disease, has a major heritable component. Susceptibility is associated with the MHC class II region, especiallyHLA-DRB5*0101–HLA-DRB1*1501–HLA-DQA1*0102–HLA-DQB1*0602haplotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4708e9c72222f94ec561264ec38b0c78
https://pubmed.ncbi.nlm.nih.gov/19380721
https://pubmed.ncbi.nlm.nih.gov/19380721
Autor:
George C. Ebers, Michael J. Chao, Gabriele C. DeLuca, Blanca M. Herrera, Sarah M. Orton, Lahiru Handunnetthi, Matthew R. Lincoln, A. Dessa Sadovnick, Sreeram V. Ramagopalan, David A. Dyment
Publikováno v:
Journal of neuroimmunology. 196(1-2)
Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. HLA-DRB1*14 and DRB1*11 bearing haplotypes protect against MS and DRB1*01 and DRB1*10 interact wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d9c6a1ec9a2d7ec1ab8d075dd6d5b2
http://ora.ox.ac.uk/objects/uuid:5144c9e1-8706-4f49-a4bc-687264cb9687
http://ora.ox.ac.uk/objects/uuid:5144c9e1-8706-4f49-a4bc-687264cb9687