Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sarah M. Mense"'
Autor:
Cindy Hodakoski, Ramon Parsons, Phillip T. Hawkins, Douglas Barrows, Megan Keniry, Sarah M. Mense, Benjamin D. Hopkins, Karen E. Anderson, Philip A. Kern, Len R. Stephens
Publikováno v:
Proceedings of the National Academy of Sciences. 111:155-160
Insulin activation of phosphoinositide 3-kinase (PI3K) signaling regulates glucose homeostasis through the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3). The dual-specificity phosphatase and tensin homolog deleted on chromosome 10 (PT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5c6cef0e3d2a80d9d078222e77c736
https://doi.org/10.1073/pnas.1213773111
https://doi.org/10.1073/pnas.1213773111
Autor:
Liang Lei, Joshua U. Klein, Benjamin Amendolara, Zachary Rapp, Benjamin D. Hopkins, Jennifer S. Yu, Barry Fine, Kyrie Pappas, Jeffrey N. Bruce, Maria Luisa Sulis, Matthew Maurer, Cindy Hodakoski, Hanina Hibshoosh, Sarah M. Mense, Meaghan Dendy, Sarah Pegno, Peter Canoll, Hannah E. Goldstein, Ramon Parsons, Nicole Steinbach, Jacquelyn Shaw
Publikováno v:
Science. 341:399-402
PTEN Variations The product of the tumor suppressor gene phosphate and tensin homolog on chromosome ten ( PTEN) is a lipid and protein phosphatase that regulates important cellular processes, including growth, survival, and metabolism (see the Perspe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19875f4551bd06f6d9ebded22b45660
https://doi.org/10.1126/science.1234907
https://doi.org/10.1126/science.1234907
Autor:
Ashley Calahan, Andrea Califano, Ben Hopkins, Ying Ka Ingar Lau, Susan Koujak, Matt Maurer, Ronald A. DePinho, Sarah M. Mense, Ramon Parsons, Megan Keniry, Celine Lefebvre, Karen Justiano, Boyi Gan, Franklyn Fenton, Joseph Toole, Maira M. Pires, Cindy Hodakoski
Publikováno v:
Genes & Development. 27:916-927
Depending on the circumstance, FOXO (Forkhead O) (FOXO1, FOXO3, and FOXO4) transcription factors activate the expression of markedly different sets of genes to produce different phenotypic effects. For example, distinct FOXO-regulated transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebaa3c67d5a97427669eb575bab197d7
https://doi.org/10.1101/gad.214049.113
https://doi.org/10.1101/gad.214049.113
Autor:
Hanina Hibshoosh, Matthew Maurer, Lao H. Saal, Megan Keniry, Benjamin D. Hopkins, Barry Fine, Tao Su, Ramon Parsons, Cindy Hodakoski, Susan Koujak, Maria Luisa Sulis, Sarah M. Mense
Publikováno v:
Science. 325:1261-1265
Reigning In Tumor Suppression Mitogenic signaling through phosphoinositide-3 kinase generates the lipid second messenger phosphatidyl inositol 3,4,5-trisphosphate (PIP3). The tumor suppressor gene product and lipid phosphatase PTEN (phosphatase and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb0a9d06f2f168c182fc4031daa2660
https://doi.org/10.1126/science.1173569
https://doi.org/10.1126/science.1173569
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 23:202-211
Exposure to estrogens is suggested to be a risk factor in human breast cancer development. The mechanisms underlying estrogen-induced cancer have not been fully elucidated. Both estrogen receptor (ER)-mediated proliferative processes and ER-independe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aaefccfe7d9f3c32114109aa48a6e2b
https://doi.org/10.1002/jbt.20281
https://doi.org/10.1002/jbt.20281
Autor:
Hari K. Bhat, Tom K. Hei, Sarah M. Mense, Mahmoud El-Tamer, Fabrizio Remotti, Ashima Bhan, Bhupendra Singh
Publikováno v:
Toxicology and Applied Pharmacology. 232:78-85
Epidemiological evidence indicates that prolonged lifetime exposure to estrogen is associated with elevated breast cancer risk in women. Oxidative stress and estrogen receptor-associated proliferative changes are suggested to play important roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53e7a991144b930002dc84dfa3d0b3a
https://doi.org/10.1016/j.taap.2008.06.007
https://doi.org/10.1016/j.taap.2008.06.007
Publikováno v:
Environmental Health Perspectives
Objective Phytoestrogens display an array of pharmacologic properties, and in recent years investigation of their potential as anticancer agents has increased dramatically. In this article we review the published literature related to phytoestrogens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e96db867b6ed2e58230f04fcecdd90
https://doi.org/10.1289/ehp.10538
https://doi.org/10.1289/ehp.10538
Publikováno v:
Science Signaling. 8
This Podcast features an interview with Sarah Mense and Ramon Parsons, authors of a Research Article that appears in the 31 March 2015 issue of Science Signaling , about how cancer-associated mutations in PREX2 overcome the tumor-suppressive effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ba8a874d8841ba780eefffed48b2093
https://doi.org/10.1126/scisignal.aab1358
https://doi.org/10.1126/scisignal.aab1358
Autor:
Benjamin D. Hopkins, Ramon Parsons, Sarah M. Mense, David Schoenfeld, Cindy Hodakoski, Barry Fine, Tao Su, Hanina Hibshoosh, Douglas Barrows, Nicole Steinbach, William Su
The tumor suppressor PTEN restrains cell migration and invasion by a mechanism that is independent of inhibition of the PI3K pathway and decreased activation of the kinase AKT. PREX2, a widely distributed GEF that activates the GTPase RAC1, binds to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5056bcf6cee82d744f2c5aa2b051c61
https://europepmc.org/articles/PMC4874664/
https://europepmc.org/articles/PMC4874664/
Autor:
Robin M. Whyatt, Galina Bentsman, Sarah M. Mense, David J. Volsky, Amitabha Sengupta, Frederica P. Perera, Changgui Lan, Mei Zhou, Li Zhang
Publikováno v:
Toxicological Sciences. 93:125-135
Given the widespread use of insecticides in the environment, it is important to perform studies evaluating their potential effects on humans. Organophosphate insecticides, such as chlorpyrifos, are being phased out; however, the use of pyrethroids in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a87755045233ffc62d5b065d6ea8fe
https://doi.org/10.1093/toxsci/kfl046
https://doi.org/10.1093/toxsci/kfl046