Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sarah M. Francis"'
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72236 (2013)
BACKGROUND: The Retinoblastoma protein (pRB) is a key tumor suppressor that is functionally inactivated in most cancers. pRB regulates the cell division cycle and cell cycle exit through protein-protein interactions mediated by its multiple binding i
Externí odkaz:
https://doaj.org/article/ec60e7e1d7f842508692368ee72e8abe
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16434 (2011)
The ability to respond to anti-growth signals is critical to maintain tissue homeostasis and loss of this negative growth control safeguard is considered a hallmark of cancer. Negative growth regulation generally occurs during the G0/G1 phase of the
Externí odkaz:
https://doaj.org/article/ae11df70778844468a280c479604edb5
Autor:
Michael J. Thwaites, Ian Welch, Paul G. Cantalupo, James I. MacDonald, Gustavo Leone, James M. Pipas, Jean-Leon Chong, Maria Teresa Sáenz-Robles, P. M. Stafford, Matthew J. Cecchini, Frederick A. Dick, Srikanth Talluri, Sarah M. Francis, Daniel Thompsen Passos
Publikováno v:
Paediatrics Publications
The retinoblastoma protein (pRB) is best known for regulating cell proliferation through E2F transcription factors. In this report, we investigate the properties of a targeted mutation that disrupts pRB interactions with the transactivation domain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1fe65729195b15e8e3b13ea856a76a
https://doi.org/10.1128/mcb.01589-13
https://doi.org/10.1128/mcb.01589-13
Autor:
Lisa M. Julian, Lea Harrington, Laurie A. Seifried, Frederick A. Dick, Nathalie G. Bérubé, Ulrich K. Binné, Nicholas J. Dyson, Sarah M. Francis, Natalie Erdmann, Christian Isaac, Alison L. Martens, Piotr Sicinski
Publikováno v:
Molecular and Cellular Biology. 26:3659-3671
The retinoblastoma protein (pRb) has been proposed to regulate cell cycle progression in part through its ability to interact with enzymes that modify histone tails and create a repressed chromatin structure. We created a mutation in the murine Rb1 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffe9c73ab5d2eedd0db378c11e0c681
https://doi.org/10.1128/mcb.26.9.3659-3671.2006
https://doi.org/10.1128/mcb.26.9.3659-3671.2006
Publikováno v:
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 21(4)
Purpose This study explored the potential financial benefits associated with dose rounding three costly cancer agents: bevacizumab, trastuzumab, and cetuximab. Methods Electronic chemotherapy health record software was queried to identify inpatient a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e10246c9a7cd40efab12c650c40dd7
https://pubmed.ncbi.nlm.nih.gov/24821690
https://pubmed.ncbi.nlm.nih.gov/24821690
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 58(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ffbb7915afdb1dd352e4e7fb574871
https://pubmed.ncbi.nlm.nih.gov/23839999
https://pubmed.ncbi.nlm.nih.gov/23839999
Publikováno v:
PLoS ONE
Paediatrics Publications
PLoS ONE, Vol 6, Iss 2, p e16434 (2011)
Paediatrics Publications
PLoS ONE, Vol 6, Iss 2, p e16434 (2011)
Background: The ability to respond to anti-growth signals is critical to maintain tissue homeostasis and loss of this negative growth control safeguard is considered a hallmark of cancer. Negative growth regulation generally occurs during the G0/G1 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825d313a0de8d5bdfd777d89e4fc2ad9
https://pubmed.ncbi.nlm.nih.gov/21364977
https://pubmed.ncbi.nlm.nih.gov/21364977
Autor:
Alison L. Martens, Kieran Ritchie, Subrata Chakrabarti, Frederick A. Dick, Courtney H. Coschi, Sarah M. Francis, Nathalie G. Bérubé
Publikováno v:
Biochemistry Publications
The compaction of the mammalian genome into mitotic chromosomes, and their faithful segregation to recipient daughter cells in mitosis, is a critical event for eukaryotic cells. This stage of the cell division cycle carries considerable risk, as ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9875ca2e2e16ce402165b5f5447d1ccb
https://ir.lib.uwo.ca/biochempub/106
https://ir.lib.uwo.ca/biochempub/106
Publikováno v:
Cancer Cell International, Vol 10, Iss 1, p 8 (2010)
Biochemistry Publications
Cancer Cell International
Biochemistry Publications
Cancer Cell International
Background The interaction between viral oncoproteins such as Simian virus 40 TAg, adenovirus E1A, and human papilloma virus E7, and the retinoblastoma protein (pRB) occurs through a well characterized peptide sequence, LXCXE, on the viral protein an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4527962c9b6036d2b41c3566aecdbbf4
http://www.cancerci.com/content/10/1/8
http://www.cancerci.com/content/10/1/8
Autor:
Frederick A. Dick, Shauna A. Henley, Christian Isaac, Sarah M. Francis, Srikanth Talluri, Mohammad Ahmad, Rod Bremner, Alison L. Martens
Publikováno v:
Biochemistry Publications
Terminally differentiated cell types are needed to live and function in a postmitotic state for a lifetime. Cellular senescence is another type of permanent arrest that blocks the proliferation of cells in response to genotoxic stress. Here we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cffc75f32e4d3654301808fe8b5e216
https://ir.lib.uwo.ca/biochempub/78
https://ir.lib.uwo.ca/biochempub/78