Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Sarah M. Fortune"'
Autor:
Sasha E. Larsen, Hazem F. M. Abdelaal, Courtney R. Plumlee, Sara B. Cohen, Ho D. Kim, Holly W. Barrett, Qingyun Liu, Matthew H. Harband, Bryan J. Berube, Susan L. Baldwin, Sarah M. Fortune, Kevin B. Urdahl, Rhea N. Coler
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The three programs that make up the Immune Mechanisms of Protection Against Mycobacterium tuberculosis Centers (IMPAc-TB) had to prioritize and select strains to be leveraged for this work. The CASCADE team based at Seattle Children’s Research Inst
Externí odkaz:
https://doaj.org/article/aeee2ded1b5d4b998456581f74d8ed36
Autor:
Cheng Bei, Junhao Zhu, Peter H. Culviner, Mingyu Gan, Eric J. Rubin, Sarah M. Fortune, Qian Gao, Qingyun Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Transcriptional regulation is a critical adaptive mechanism that allows bacteria to respond to changing environments, yet the concept of transcriptional plasticity (TP) – the variability of gene expression in response to environmental chan
Externí odkaz:
https://doaj.org/article/eccd51b1d0cb4a738426c4d6f01cfc50
Autor:
Swati Jaiswal, Sarah K. Nyquist, Shayla Boyce, Tasneem Jivanjee, Samira Ibrahim, Joshua D. Bromley, G. James Gatter, Hannah Gideon, Kush Patel, Sharie Keanne Ganchua, Bonnie Berger, Sarah M. Fortune, JoAnne L. Flynn, Alex K. Shalek, Samuel M. Behar
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Cynomolgus macaque (Macaca fascicularis) is an attractive animal model for the study of human disease and is extensively used in biomedical research. Cynomolgus macaques share behavioral, physiological, and genomic traits with hum
Externí odkaz:
https://doaj.org/article/0fcfddea48094cb580d2427baab18647
Autor:
Leela R.L. Davies, Malisa T. Smith, Deniz Cizmeci, Stephanie Fischinger, Jessica Shih-Lu Lee, Lenette L. Lu, Erik D. Layton, Alison D. Grant, Katherine Fielding, Catherine M. Stein, W. Henry Boom, Thomas R. Hawn, Sarah M. Fortune, Robert S. Wallis, Gavin J. Churchyard, Galit Alter, Chetan Seshadri
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104678- (2023)
Summary: Background: The prevalence of tuberculosis among men who work in the gold mines of South Africa is among the highest in the world, but a fraction of miners demonstrate consistently negative results upon tuberculin skin test (TST) and IFN-γ
Externí odkaz:
https://doaj.org/article/0c58ca4c3fba49d19ebee7d80aaf7eba
Autor:
Nadege Nziza, Wonyeong Jung, Maanasa Mendu, Tina Chen, Ryan P. McNamara, Sarah M. Fortune, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Bryan Bryson, Joseph Ngonzi, Lisa M. Bebell, Galit Alter
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionPlacental transfer of maternal antibodies is essential for neonatal immunity over the first months of life. In the setting of maternal HIV infection, HIV-exposed uninfected (HEU) infants are at higher risk of developing severe infections,
Externí odkaz:
https://doaj.org/article/1aefa836d3c6451790963fe3a513e28d
Autor:
Melissa Bedard, Sanne van der Niet, Elliott M. Bernard, Gregory Babunovic, Tan-Yun Cheng, Beren Aylan, Anita E. Grootemaat, Sahadevan Raman, Laure Botella, Eri Ishikawa, Mary P. O’Sullivan, Seónadh O’Leary, Jacob A. Mayfield, Jeffrey Buter, Adriaan J. Minnaard, Sarah M. Fortune, Leon O. Murphy, Daniel S. Ory, Joseph Keane, Sho Yamasaki, Maximiliano G. Gutierrez, Nicole van der Wel, D. Branch Moody
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche. Here, we show that a terpenyl
Externí odkaz:
https://doaj.org/article/66ad604010504fdab74173379c2c7ca6
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
In the face of the unrelenting global burden of tuberculosis (TB), antibiotics remain our most effective tools to save lives and control the spread of Mycobacterium tuberculosis (Mtb). However, we confront a dual challenge in our use of antibiotics:
Externí odkaz:
https://doaj.org/article/733fa8365e5c451e9e78164bd2e514f7
Autor:
Allison F. Carey, Xin Wang, Nico Cicchetti, Caitlin N. Spaulding, Qingyun Liu, Forrest Hopkins, Jessica Brown, Jaimie Sixsmith, Rujapak Sutiwisesak, Samuel M. Behar, Thomas R. Ioerger, Sarah M. Fortune
Publikováno v:
mSystems, Vol 7, Iss 3 (2022)
ABSTRACT There is growing evidence that genetic diversity in Mycobacterium tuberculosis, the causative agent of tuberculosis, contributes to the outcomes of infection and public health interventions, such as vaccination. Epidemiological studies sugge
Externí odkaz:
https://doaj.org/article/13c144ed64584ffa9e4d276cd663ac62
Autor:
Ryan V. Moriarty, Mark A. Rodgers, Amy L. Ellis, Alexis J. Balgeman, Erica C. Larson, Forrest Hopkins, Michael R. Chase, Pauline Maiello, Sarah M. Fortune, Charles A. Scanga, Shelby L. O’Connor
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Individuals co-infected with HIV and Mycobacterium tuberculosis (Mtb) are more likely to develop severe tuberculosis (TB) disease than HIV-naive individuals. To understand how a chronic pre-existing Simian immunodeficiency virus (SIV) infect
Externí odkaz:
https://doaj.org/article/492e19bcf78a4140bfc2ee5b6a89f818
Autor:
Francesca G. Tomasi, Alexander M. J. Hall, Jessica T. P. Schweber, Charles L. Dulberger, Kerry McGowen, Qingyun Liu, Sarah M. Fortune, Sophie Helaine, Eric J. Rubin
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Toxin-antitoxin (TA) systems allow bacteria to adapt to changing environments without altering gene expression. Despite being overrepresented in Mycobacterium tuberculosis, their physiological roles remain elusive. We describe a TA system in
Externí odkaz:
https://doaj.org/article/602d614c59864e1ba91784c01109f788