Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sarah M. Alam"'
Autor:
Guillaume M. Hautbergue, Lydia M. Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Adrian Higginbottom, Ya-Hui Lin, Claudia S. Bauer, Jennifer E. Dodd, Monika A. Myszczynska, Sarah M. Alam, Pierre Garneret, Jayanth S. Chandran, Evangelia Karyka, Matthew J. Stopford, Emma F. Smith, Janine Kirby, Kathrin Meyer, Brian K. Kaspar, Adrian M. Isaacs, Sherif F. El-Khamisy, Kurt J. De Vos, Ke Ning, Mimoun Azzouz, Alexander J. Whitworth, Pamela J. Shaw
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
The RNA for ALS- and frontotemporal dementia-associated C9ORF72 gene is exported from nucleus via an unknown mechanism. This study shows that reduction of nuclear export adaptor SRSF1 can alleviate neuronal cell death and nuclear export of C9ORF72 in
Externí odkaz:
https://doaj.org/article/26d01605fb7344faaa67f88fe2c80e8f
Autor:
Alice Biosa, Sarah M Alam, Marco Bisaglia, Luigi Bubacco, Alvaro Sanchez-Martinez, Mariano Beltramini, Alexander J. Whitworth, Roberta Filograna, Ana Terriente-Felix
Publikováno v:
Human Molecular Genetics
Reactive oxygen species exert important functions in regulating several cellular signalling pathways. However, an excessive accumulation of reactive oxygen species can perturb the redox homeostasis leading to oxidative stress, a condition which has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba2e44aea1a7f68c7b1539376d36a2c
https://pubmed.ncbi.nlm.nih.gov/29529199
https://pubmed.ncbi.nlm.nih.gov/29529199
Autor:
Claudia S. Bauer, Matthew J. Stopford, Emma F. Smith, Brian K. Kaspar, Janine Kirby, Alvaro Sanchez-Martinez, Kathrin Meyer, Jennifer E Dodd, Kurt J. De Vos, Lydia M. Castelli, Ke Ning, Laura Ferraiuolo, Alexander J. Whitworth, Johnathan Cooper-Knock, Adrian Higginbottom, Pamela J. Shaw, Sarah M Alam, Sherif F. El-Khamisy, Jayanth S. Chandran, Adrian M. Isaacs, Monika A Myszczynska, Ya-Hui Lin, Evangelia Karyka, Guillaume M. Hautbergue, Mimoun Azzouz, Pierre Garneret
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Expression of repeat transcripts and dipeptide repeat proteins trigger multiple mechanisms of neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d007653a2eb673cd91300b93d07155c6