Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sarah M McAlpine"'
Autor:
Anikó E. Malik, Drew Slauenwhite, Sarah M. McAlpine, John G. Hanly, Jean S. Marshall, Beáta Dérfalvi, Thomas B. Issekutz
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundThe role of type I and type III interferons (IFNs) in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) is still poorly understood. The objective of this study was to examine the hypothesis that IFN expression profiles in th
Externí odkaz:
https://doaj.org/article/6604fe21c02a4a40848cb6c541f0e5ce
Autor:
Anikó E. Malik, Drew Slauenwhite, Sarah M. McAlpine, John G. Hanly, Jean S. Marshall, Thomas B. Issekutz
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveAntigen-presenting dendritic cells (DCs) and monocytes play an essential role in rheumatoid arthritis (RA) pathogenesis, however, their tolerogenic potential remains unclear. Herein, the tolerogenic profiles of DCs are characterized in treat
Externí odkaz:
https://doaj.org/article/ada887f28e424002807018d3e254353f
Autor:
Michael G Brown, Sarah M McAlpine, Yan Y Huang, Ian D Haidl, Ayham Al-Afif, Jean S Marshall, Robert Anderson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34055 (2012)
Dengue hemorrhagic fever and/or dengue shock syndrome represent the most serious pathophysiological manifestations of human dengue virus infection. Despite intensive research, the mechanisms and important cellular players that contribute to dengue di
Externí odkaz:
https://doaj.org/article/83932672101b43b29516d14dcfe88f64
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Juvenile Idiopathic Arthritis (JIA) is the most prevalent chronic pediatric rheumatic disorder. In joints of JIA patients, aggressive phenotypic changes in fibroblast-like synoviocytes (FLS) of the synovial lining play a key role
Externí odkaz:
https://doaj.org/article/f0f8b3a5436f42c5be5a32a6c623de2d
Autor:
Sarah M. McAlpine, Sarah E. Roberts, John J. Heath, Fabian Käsermann, Andrew C. Issekutz, Thomas B. Issekutz, Beata Derfalvi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Intravenous immunoglobulin (IVIG) is an effective immunomodulatory treatment for immune dysregulation diseases. However, the mechanisms by which it reduces systemic inflammation are not well understood. NK cell cytotoxicity is decreased by IVIG in wo
Externí odkaz:
https://doaj.org/article/ea9f95a0079b4145a5cc45eefede390a
Autor:
Sarah M. McAlpine, Sarah E. Roberts, Breanna K.V. Hargreaves, Claire Bullock, Suzanne Ramsey, Elizabeth Stringer, Bianca Lang, Adam Huber, Bence György, Fruzsina Erdélyi, Thomas B. Issekutz, Beáta Dérfalvi
Publikováno v:
The Journal of rheumatology.
ObjectiveTo evaluate microRNA expression in synovial fluid (SF), plasma, and leukocytes from patients with juvenile idiopathic arthritis (JIA).MethodsMicroRNA expression in pooled JIA plasma and SF was assessed by absolute quantitative droplet digita
Autor:
Drew Slauenwhite, J G Hanly, Thomas B. Issekutz, Jean S. Marshall, Aniko Malik, Sarah M. McAlpine, Ian D. Haidl
Publikováno v:
Arthritis & Rheumatology. 72:1091-1102
OBJECTIVE Rheumatoid arthritis (RA) is a chronic inflammatory disease mediated through complex immunologic pathways. Among RA patients receiving low-dose methotrexate (MTX) monotherapy, approximately one-half exhibit a meaningful clinical response wi
Autor:
Nora Alrumayyan, Drew Slauenwhite, Sarah M. McAlpine, Sarah Roberts, Thomas B. Issekutz, Adam M. Huber, Zaiping Liu, Beata Derfalvi
Publikováno v:
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. 18(1)
Background Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins, such as collagen. PD is c
Autor:
John J Heath, Fabian Käsermann, Beata Derfalvi, Sarah M. McAlpine, Andrew C. Issekutz, Sarah E. Roberts, Thomas B. Issekutz
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Intravenous immunoglobulin (IVIG) is an effective immunomodulatory treatment for immune dysregulation diseases. However, the mechanisms by which it reduces systemic inflammation are not well understood. NK cell cytotoxicity is decreased by IVIG in wo
Publikováno v:
The FASEB Journal. 26:1280-1289
The trafficking of effector cells to sites of infection is crucial for antiviral responses. However, the mechanisms of recruitment of the interferon-γ-producing and cytotoxic CD56(+) T cells are poorly understood. Human mast cells are sentinel cells