Výsledky vyhledávání

Akademický článek

Oncogenic SLC2A11–MIF fusion protein interacts with polypyrimidine tract binding protein 1 to facilitate bladder cancer proliferation and metastasis by regulating mRNA stability

Autor: Liang Cheng, Chenwei Yang, Junlin Lu, Ming Huang, Ruihui Xie, Sarah Lynch, Justin Elfman, Yuhang Huang, Sen Liu, Siting Chen, Baoqing He, Tianxin Lin, Hui Li, Xu Chen, Jian Huang

Publikováno v: MedComm, Vol 5, Iss 9, Pp n/a-n/a (2024)

Abstract Chimeric RNAs, distinct from DNA gene fusions, have emerged as promising therapeutic targets with diverse functions in cancer treatment. However, the functional significance and therapeutic potential of most chimeric RNAs remain unclear. Her

Externí odkaz: https://doaj.org/article/9c8720ea7f8f4b6ca77e0c3abbc4c3d0

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Akademický článek

147 Targeting a novel chimeric RNA, A-B, as a non-traditional therapeutic in colorectal cancer

Autor: Sarah Lynch

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/6af09a1081bd4ab2963b4991a6c08cc7

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Akademický článek

Promoting Empathy and Affiliation in Relationships (PEAR) study: protocol for a longitudinal study investigating the development of early childhood callous-unemotional traits

Autor: Nicholas Wagner, Emily Perkins, Yuheiry Rodriguez, Cora Ordway, Michaela Flum, Lucia Hernandez-Pena, Polina Perelstein, Kathy Sem, Yael Paz, Rista Plate, Ayomide Popoola, Sarah Lynch, Kristina Astone, Ethan Goldstein, Wanjikũ F M Njoroge, Adriane Raine, Donna Pincus, Koraly Pérez-Edgar, Rebecca Waller

Publikováno v: BMJ Open, Vol 13, Iss 10 (2023)

Introduction Children with callous-unemotional (CU) traits are at high lifetime risk of antisocial behaviour. Low affiliation (ie, social bonding difficulties) and fearlessness (ie, low threat sensitivity) are proposed risk factors for CU traits. Par

Externí odkaz: https://doaj.org/article/ec69804fa18243a6a8313058e09cbc0d

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Akademický článek

Pupils and Sources in Late Medieval Lyon

Autor: Sarah Lynch

Publikováno v: Espacio, Tiempo y Educación, Vol 2, Iss 2, Pp 289-311 (2015)

The medieval elementary and grammar-school pupil is a partially-hidden figure in the documentary sources of the period. Their existence, and their existence in abundance, is clear from the fact that so many schools and teachers were operating in the

Externí odkaz: https://doaj.org/article/c1fef236b6b24bf9aa27a1e4e811696f

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Akademický článek

Regional susceptibility to TNF-α induction of murine brain inflammation via classical IKK/NF-κB signalling.

Autor: Adam M H Young, Elaine C Campbell, Sarah Lynch, Malcolm H Dunn, Simon J Powis, John Suckling

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39049 (2012)

It is becoming clear that inflammation plays a significant role in a number of neurological and psychiatric conditions. Post mortem brain samples in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, schizoph

Externí odkaz: https://doaj.org/article/b4a520febba44629b198f79c4581ab0b

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Elektronická kniha

Elementary and Grammar Education in Late Medieval France : Lyon, 1285-1530

Autor: Sarah Lynch

The fourteenth and fifteenth centuries saw a marked increase in the availability of elementary and grammar education in Europe. In France, that rise took the form of a unique blend of trends also seen elsewhere in Europe, ranging from Church-dominate

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