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Autor:
Iain James, Stuart D.C. Ward, Sarah Louise Mellor, Philip J. Birch, Lars J. S. Knutsen, J. Russell Burley, Fiumana Andrea, Jenny Christine Ionix Pharmaceuticals Ltd Gilbert, Nichola Smith, Fleur Radford, Christopher Hobbs, Christopher Geoffrey Earnshaw
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:662-667
A series of new N-type (Cav2.2) calcium channel blockers derived from the ‘hit’ structures 2-(3-bromo-4-fluorophenyl)-3-(2-pyridin-2-ylethyl)thiazolidin-4-one 9 and its 2-[4-(4-bromophenyl)pyridin-3-yl]-3-isobutyl analogue 10 is described. Extens